Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised, we identified pathwa...

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Veröffentlicht in:	The Journal of cell biology 2020-07, Vol.219 (7)
Hauptverfasser:	Ho, Nurulain, Yap, Wei Sheng, Xu, Jiaming, Wu, Haoxi, Koh, Jhee Hong, Goh, Wilson Wen Bin, George, Bhawana, Chong, Shu Chen, Taubert, Stefan, Thibault, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosensing Techniques Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Chromatin Chromatin - chemistry Chromatin - metabolism Endoplasmic Reticulum Endoplasmic Reticulum Stress - genetics Gene expression Gene Expression Profiling Gene Expression Regulation Genes, Reporter Genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Helices Homeostasis Homeostasis - genetics Immunoprecipitation Integrity Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Lipid bilayers Lipid Bilayers - chemistry Lipid Bilayers - metabolism Lipid composition Lipid metabolism Lipid Metabolism - genetics Lipids Luminescent Proteins - genetics Luminescent Proteins - metabolism Membrane and Lipid Biology Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membranes Metabolic disorders Metabolism Potassium Protein folding Protein Homeostasis Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteins Red Fluorescent Protein Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sensors Transcription Transcription, Genetic Unfolded Protein Response Yeast Yeasts
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