Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity

G protein-coupled receptor 120 (GPR120) and PPARγ agonists each have insulin sensitizing effects. But whether these two pathways functionally interact and can be leveraged together to markedly improve insulin resistance has not been explored. Here, we show that treatment with the PPARγ agonist rosig...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell metabolism 2020-06, Vol.31 (6), p.1173-1188.e5
Hauptverfasser:	Paschoal, Vivian A., Walenta, Evelyn, Talukdar, Saswata, Pessentheiner, Ariane R., Osborn, Olivia, Hah, Nasun, Chi, Tyler J., Tye, George L., Armando, Aaron M., Evans, Ronald M., Chi, Nai-Wen, Quehenberger, Oswald, Olefsky, Jerrold M., Oh, Da Young
Format:	Artikel
Sprache:	eng
Schlagworte:	15d-PGJ2 combination therapy Compound A GPR120 insulin resistance PPARγ thiazolidinedione type 2 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!