Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report
Myeloid sarcoma (MS) is a rare tumor mass. It may occur at any extramedullary anatomic sites but is uncommon in the sinonasal location.MS commonly presents concurrently with acute myeloid leukemia (AML), but it may predate AML over several months or years, named isolated MS. We report a case of a 15...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-07, Vol.99 (27), p.e21119-e21119 |
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| creator | Liu, Ruowu Du, Jintao Gao, Limin Liu, Yafeng Liu, Shixi |
| description | Myeloid sarcoma (MS) is a rare tumor mass. It may occur at any extramedullary anatomic sites but is uncommon in the sinonasal location.MS commonly presents concurrently with acute myeloid leukemia (AML), but it may predate AML over several months or years, named isolated MS.
We report a case of a 15-month-old child who presented with mouth breathing, bilateral rhinorrhea, palpebral edema and proptosis. The routine blood tests were normal for the first few months. Computed tomography scan revealed neoplasm in nasal cavity.
The patient was definitely diagnosed with isolated MS in the nasal cavity through immunohistochemistry combined with clinical features and radiological investigations, and MS further progressed to AML which was confirmed by hematologist.
Endoscopic sinus surgery was performed to acquire specimens. After diagnosis, the patient was promptly treated with systemic chemotherapy.
All symptoms gradually subsided and the mass of nasal cavity was invisible. No relapse occurred during follow-up.
Sinonasal MS may be misdiagnosed and should be considered when symptoms persist and worsen. Prompt clinic examinations are essential for cases with suspected MS. Diagnosis of MS is dependent on the immunohistological investigations combined with clinical features, radiological investigations. Early diagnosis and systemic chemotherapy are vital for patients to achieve best prognosis. |
| doi_str_mv | 10.1097/MD.0000000000021119 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7337411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2421124196</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3555-69c7088fa54e863b2103bf27b8e9a7e866f635af2dc4c089866096b13e1685893</originalsourceid><addsrcrecordid>eNpdkUtv1DAUha2Kig6FX1AJecnGxW_HLJCqllfVERtYW45z0wSceLAzrebfY5i-wItr6dzvHlv3IHTC6Cmj1rxdX5zSx8MZY_YArZgSmiir5TO0qqoixhp5hF6U8oNSJgyXz9GR4JpXWa_Q5XoHMY0dLj6HNHmcerwMgGdffMTB34zLDo8z9pgpMqV5GUiKHQ7DGLt3-KwSBXCGTcrLS3TY-1jg1d19jL5__PDt_DO5-vrpy_nZFQlCKUW0DYY2Te-VhEaLljMq2p6btgHrTZV0r4XyPe-CDLSxVaBWt0wA041qrDhG7_e-m207QRdgXrKPbpPHyeedS350_3bmcXDX6cYZIYxkrBq8uTPI6dcWyuKmsQSI0c-QtsVxWZfJJbO6omKPhpxKydA_PMOo-5OCW1-4_1OoU6-f_vBh5n7tFZB74DbFBXL5Gbe3kN0APi7DXz9lLCecckpNLaRGx5X4DSmNkDA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2421124196</pqid></control><display><type>article</type><title>Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wolters Kluwer Open Health</source><source>IngentaConnect Free/Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Liu, Ruowu ; Du, Jintao ; Gao, Limin ; Liu, Yafeng ; Liu, Shixi</creator><creatorcontrib>Liu, Ruowu ; Du, Jintao ; Gao, Limin ; Liu, Yafeng ; Liu, Shixi</creatorcontrib><description>Myeloid sarcoma (MS) is a rare tumor mass. It may occur at any extramedullary anatomic sites but is uncommon in the sinonasal location.MS commonly presents concurrently with acute myeloid leukemia (AML), but it may predate AML over several months or years, named isolated MS.
We report a case of a 15-month-old child who presented with mouth breathing, bilateral rhinorrhea, palpebral edema and proptosis. The routine blood tests were normal for the first few months. Computed tomography scan revealed neoplasm in nasal cavity.
The patient was definitely diagnosed with isolated MS in the nasal cavity through immunohistochemistry combined with clinical features and radiological investigations, and MS further progressed to AML which was confirmed by hematologist.
Endoscopic sinus surgery was performed to acquire specimens. After diagnosis, the patient was promptly treated with systemic chemotherapy.
All symptoms gradually subsided and the mass of nasal cavity was invisible. No relapse occurred during follow-up.
Sinonasal MS may be misdiagnosed and should be considered when symptoms persist and worsen. Prompt clinic examinations are essential for cases with suspected MS. Diagnosis of MS is dependent on the immunohistological investigations combined with clinical features, radiological investigations. Early diagnosis and systemic chemotherapy are vital for patients to achieve best prognosis.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000021119</identifier><identifier>PMID: 32629746</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - therapeutic use ; Clinical Case Report ; Diagnostic Errors - prevention & control ; Early Diagnosis ; Edema - etiology ; Exophthalmos - etiology ; Eyelid Diseases - pathology ; Humans ; Immunohistochemistry - methods ; Infant ; Leukemia, Myeloid, Acute - diagnosis ; Leukemia, Myeloid, Acute - drug therapy ; Leukemia, Myeloid, Acute - surgery ; Male ; Nasal Cavity - diagnostic imaging ; Nasal Cavity - pathology ; Nasal Cavity - surgery ; Sarcoma, Myeloid - complications ; Sarcoma, Myeloid - diagnostic imaging ; Sarcoma, Myeloid - metabolism ; Tomography, X-Ray Computed - methods ; Treatment Outcome</subject><ispartof>Medicine (Baltimore), 2020-07, Vol.99 (27), p.e21119-e21119</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3555-69c7088fa54e863b2103bf27b8e9a7e866f635af2dc4c089866096b13e1685893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337411/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337411/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32629746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ruowu</creatorcontrib><creatorcontrib>Du, Jintao</creatorcontrib><creatorcontrib>Gao, Limin</creatorcontrib><creatorcontrib>Liu, Yafeng</creatorcontrib><creatorcontrib>Liu, Shixi</creatorcontrib><title>Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Myeloid sarcoma (MS) is a rare tumor mass. It may occur at any extramedullary anatomic sites but is uncommon in the sinonasal location.MS commonly presents concurrently with acute myeloid leukemia (AML), but it may predate AML over several months or years, named isolated MS.
We report a case of a 15-month-old child who presented with mouth breathing, bilateral rhinorrhea, palpebral edema and proptosis. The routine blood tests were normal for the first few months. Computed tomography scan revealed neoplasm in nasal cavity.
The patient was definitely diagnosed with isolated MS in the nasal cavity through immunohistochemistry combined with clinical features and radiological investigations, and MS further progressed to AML which was confirmed by hematologist.
Endoscopic sinus surgery was performed to acquire specimens. After diagnosis, the patient was promptly treated with systemic chemotherapy.
All symptoms gradually subsided and the mass of nasal cavity was invisible. No relapse occurred during follow-up.
Sinonasal MS may be misdiagnosed and should be considered when symptoms persist and worsen. Prompt clinic examinations are essential for cases with suspected MS. Diagnosis of MS is dependent on the immunohistological investigations combined with clinical features, radiological investigations. Early diagnosis and systemic chemotherapy are vital for patients to achieve best prognosis.</description><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Clinical Case Report</subject><subject>Diagnostic Errors - prevention & control</subject><subject>Early Diagnosis</subject><subject>Edema - etiology</subject><subject>Exophthalmos - etiology</subject><subject>Eyelid Diseases - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Infant</subject><subject>Leukemia, Myeloid, Acute - diagnosis</subject><subject>Leukemia, Myeloid, Acute - drug therapy</subject><subject>Leukemia, Myeloid, Acute - surgery</subject><subject>Male</subject><subject>Nasal Cavity - diagnostic imaging</subject><subject>Nasal Cavity - pathology</subject><subject>Nasal Cavity - surgery</subject><subject>Sarcoma, Myeloid - complications</subject><subject>Sarcoma, Myeloid - diagnostic imaging</subject><subject>Sarcoma, Myeloid - metabolism</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Treatment Outcome</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1DAUha2Kig6FX1AJecnGxW_HLJCqllfVERtYW45z0wSceLAzrebfY5i-wItr6dzvHlv3IHTC6Cmj1rxdX5zSx8MZY_YArZgSmiir5TO0qqoixhp5hF6U8oNSJgyXz9GR4JpXWa_Q5XoHMY0dLj6HNHmcerwMgGdffMTB34zLDo8z9pgpMqV5GUiKHQ7DGLt3-KwSBXCGTcrLS3TY-1jg1d19jL5__PDt_DO5-vrpy_nZFQlCKUW0DYY2Te-VhEaLljMq2p6btgHrTZV0r4XyPe-CDLSxVaBWt0wA041qrDhG7_e-m207QRdgXrKPbpPHyeedS350_3bmcXDX6cYZIYxkrBq8uTPI6dcWyuKmsQSI0c-QtsVxWZfJJbO6omKPhpxKydA_PMOo-5OCW1-4_1OoU6-f_vBh5n7tFZB74DbFBXL5Gbe3kN0APi7DXz9lLCecckpNLaRGx5X4DSmNkDA</recordid><startdate>20200702</startdate><enddate>20200702</enddate><creator>Liu, Ruowu</creator><creator>Du, Jintao</creator><creator>Gao, Limin</creator><creator>Liu, Yafeng</creator><creator>Liu, Shixi</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200702</creationdate><title>Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report</title><author>Liu, Ruowu ; Du, Jintao ; Gao, Limin ; Liu, Yafeng ; Liu, Shixi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3555-69c7088fa54e863b2103bf27b8e9a7e866f635af2dc4c089866096b13e1685893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Clinical Case Report</topic><topic>Diagnostic Errors - prevention & control</topic><topic>Early Diagnosis</topic><topic>Edema - etiology</topic><topic>Exophthalmos - etiology</topic><topic>Eyelid Diseases - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Infant</topic><topic>Leukemia, Myeloid, Acute - diagnosis</topic><topic>Leukemia, Myeloid, Acute - drug therapy</topic><topic>Leukemia, Myeloid, Acute - surgery</topic><topic>Male</topic><topic>Nasal Cavity - diagnostic imaging</topic><topic>Nasal Cavity - pathology</topic><topic>Nasal Cavity - surgery</topic><topic>Sarcoma, Myeloid - complications</topic><topic>Sarcoma, Myeloid - diagnostic imaging</topic><topic>Sarcoma, Myeloid - metabolism</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ruowu</creatorcontrib><creatorcontrib>Du, Jintao</creatorcontrib><creatorcontrib>Gao, Limin</creatorcontrib><creatorcontrib>Liu, Yafeng</creatorcontrib><creatorcontrib>Liu, Shixi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ruowu</au><au>Du, Jintao</au><au>Gao, Limin</au><au>Liu, Yafeng</au><au>Liu, Shixi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-07-02</date><risdate>2020</risdate><volume>99</volume><issue>27</issue><spage>e21119</spage><epage>e21119</epage><pages>e21119-e21119</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Myeloid sarcoma (MS) is a rare tumor mass. It may occur at any extramedullary anatomic sites but is uncommon in the sinonasal location.MS commonly presents concurrently with acute myeloid leukemia (AML), but it may predate AML over several months or years, named isolated MS.
We report a case of a 15-month-old child who presented with mouth breathing, bilateral rhinorrhea, palpebral edema and proptosis. The routine blood tests were normal for the first few months. Computed tomography scan revealed neoplasm in nasal cavity.
The patient was definitely diagnosed with isolated MS in the nasal cavity through immunohistochemistry combined with clinical features and radiological investigations, and MS further progressed to AML which was confirmed by hematologist.
Endoscopic sinus surgery was performed to acquire specimens. After diagnosis, the patient was promptly treated with systemic chemotherapy.
All symptoms gradually subsided and the mass of nasal cavity was invisible. No relapse occurred during follow-up.
Sinonasal MS may be misdiagnosed and should be considered when symptoms persist and worsen. Prompt clinic examinations are essential for cases with suspected MS. Diagnosis of MS is dependent on the immunohistological investigations combined with clinical features, radiological investigations. Early diagnosis and systemic chemotherapy are vital for patients to achieve best prognosis.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>32629746</pmid><doi>10.1097/MD.0000000000021119</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Clinical Case Report Diagnostic Errors - prevention & control Early Diagnosis Edema - etiology Exophthalmos - etiology Eyelid Diseases - pathology Humans Immunohistochemistry - methods Infant Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - surgery Male Nasal Cavity - diagnostic imaging Nasal Cavity - pathology Nasal Cavity - surgery Sarcoma, Myeloid - complications Sarcoma, Myeloid - diagnostic imaging Sarcoma, Myeloid - metabolism Tomography, X-Ray Computed - methods Treatment Outcome |
| title | Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report |
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