Identification of Cartilage Microbial DNA Signatures and Associations With Knee and Hip Osteoarthritis

Objective Alterations of the gut microbiota have been implicated in many forms of arthritis, but an examination of cartilage microbial patterns has not been performed. This study was undertaken to characterize the microbial DNA profile of articular cartilage and determine changes associated with ost...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2020-07, Vol.72 (7), p.1111-1122
Hauptverfasser:	Dunn, Christopher M., Velasco, Cassandra, Rivas, Alexander, Andrews, Madison, Garman, Cassandra, Jacob, Paul B., Jeffries, Matlock A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Arthritis Arthroplasty, Replacement, Hip Arthroplasty, Replacement, Knee Biomedical materials Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - metabolism Cartilage, Articular - microbiology Cartilage, Articular - pathology Classification Constituents Deoxyribonucleic acid Disease Susceptibility DNA DNA, Bacterial - analysis Female Functional analysis Gene sequencing Genetic Variation Hip Humans Intestinal microflora Knee Lipid metabolism Lipopolysaccharides Male Metabolism Metagenome - genetics Metagenomics Mice Microbiota Microbiota - genetics Microorganisms Middle Aged Nitrogen metabolism Osteoarthritis Osteoarthritis, Hip - microbiology Osteoarthritis, Hip - surgery Osteoarthritis, Knee - microbiology Osteoarthritis, Knee - surgery Phosphatidylinositol Polymerase Chain Reaction RNA, Ribosomal, 16S - genetics rRNA 16S Signatures
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