Targeting NAD + Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance

To improve therapeutic responses in patients with glioma, new combination therapies that exploit a mechanistic understanding of the inevitable emergence of drug resistance are needed. Intratumoral heterogeneity enables a low barrier to resistance in individual patients with glioma. We reasoned that...

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Veröffentlicht in:	Molecular cancer research 2020-07, Vol.18 (7), p.1004-1017
Hauptverfasser:	Jane, Esther P, Premkumar, Daniel R, Thambireddy, Swetha, Golbourn, Brian, Agnihotri, Sameer, Bertrand, Kelsey C, Mack, Stephen C, Myers, Max I, Chattopadhyay, Ansuman, Taylor, D Lansing, Schurdak, Mark E, Stern, Andrew M, Pollack, Ian F
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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