Immune status, and not HIV infection or exposure, drives the development of the oral microbiota
Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact o...
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| creator | Coker, M. O. Mongodin, E. F. El-Kamary, S. S. Akhigbe, P. Obuekwe, O. Omoigberale, A. Langenberg, P. Enwonwu, C. Hittle, L. Blattner, W. A. Charurat, M. |
| description | Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains unclear. We hypothesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children will significantly differ from HIV-unexposed-and-uninfected (HUU) children. Saliva samples from 286 child-participants in Nigeria, aged ≤ 6 years, were analyzed using 16S rRNA gene sequencing. Perinatal HIV infection was significantly associated with community composition (HI vs. HUU—p = 0.04; HEU vs. HUU—p = 0.11) however, immune status had stronger impacts on bacterial profiles (p |
| doi_str_mv | 10.1038/s41598-020-67487-4 |
| format | Article |
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O. ; Mongodin, E. F. ; El-Kamary, S. S. ; Akhigbe, P. ; Obuekwe, O. ; Omoigberale, A. ; Langenberg, P. ; Enwonwu, C. ; Hittle, L. ; Blattner, W. A. ; Charurat, M.</creator><creatorcontrib>Coker, M. O. ; Mongodin, E. F. ; El-Kamary, S. S. ; Akhigbe, P. ; Obuekwe, O. ; Omoigberale, A. ; Langenberg, P. ; Enwonwu, C. ; Hittle, L. ; Blattner, W. A. ; Charurat, M.</creatorcontrib><description>Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains unclear. We hypothesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children will significantly differ from HIV-unexposed-and-uninfected (HUU) children. Saliva samples from 286 child-participants in Nigeria, aged ≤ 6 years, were analyzed using 16S rRNA gene sequencing. Perinatal HIV infection was significantly associated with community composition (HI vs. HUU—p = 0.04; HEU vs. HUU—p = 0.11) however, immune status had stronger impacts on bacterial profiles (p < 0.001). We observed age-stratified associations of perinatal HIV exposure on community composition, with HEU children differing from HUU children in early life but HEU children becoming more similar to HUU children with age. Our findings suggest that, regardless of age, HIV infection or exposure, low CD4 levels persistently alter the oral microbiota during this critical developmental period. Data also indicates that, while HIV infection clearly shapes the developing infant oral microbiome, the effect of perinatal exposure (without infection) appears transient.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-67487-4</identifier><identifier>PMID: 32616727</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/114 ; 631/326 ; 692/308/3187 ; 692/4017 ; Age ; Antiretroviral agents ; Antiretroviral therapy ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; Child ; Child, Preschool ; Children ; Community composition ; Dental caries ; Dental Caries - immunology ; Dental Caries - microbiology ; Dental disorders ; Female ; HIV ; HIV Infections - immunology ; HIV Infections - microbiology ; Human immunodeficiency virus ; Humanities and Social Sciences ; Humans ; Immune status ; Immunocompromised Host ; Infections ; Male ; Microbiomes ; Microbiota ; Microorganisms ; multidisciplinary ; Perinatal exposure ; rRNA 16S ; Saliva ; Saliva - microbiology ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-07, Vol.10 (1), p.10830-10830, Article 10830</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-a876f3d9e8bd3463ca91ce89e67c87968f8cd185bcd77d6bb962fc5b2aa390173</citedby><cites>FETCH-LOGICAL-c474t-a876f3d9e8bd3463ca91ce89e67c87968f8cd185bcd77d6bb962fc5b2aa390173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331591/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331591/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27911,27912,41107,42176,51563,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32616727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coker, M. O.</creatorcontrib><creatorcontrib>Mongodin, E. F.</creatorcontrib><creatorcontrib>El-Kamary, S. S.</creatorcontrib><creatorcontrib>Akhigbe, P.</creatorcontrib><creatorcontrib>Obuekwe, O.</creatorcontrib><creatorcontrib>Omoigberale, A.</creatorcontrib><creatorcontrib>Langenberg, P.</creatorcontrib><creatorcontrib>Enwonwu, C.</creatorcontrib><creatorcontrib>Hittle, L.</creatorcontrib><creatorcontrib>Blattner, W. A.</creatorcontrib><creatorcontrib>Charurat, M.</creatorcontrib><title>Immune status, and not HIV infection or exposure, drives the development of the oral microbiota</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains unclear. We hypothesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children will significantly differ from HIV-unexposed-and-uninfected (HUU) children. Saliva samples from 286 child-participants in Nigeria, aged ≤ 6 years, were analyzed using 16S rRNA gene sequencing. Perinatal HIV infection was significantly associated with community composition (HI vs. HUU—p = 0.04; HEU vs. HUU—p = 0.11) however, immune status had stronger impacts on bacterial profiles (p < 0.001). We observed age-stratified associations of perinatal HIV exposure on community composition, with HEU children differing from HUU children in early life but HEU children becoming more similar to HUU children with age. Our findings suggest that, regardless of age, HIV infection or exposure, low CD4 levels persistently alter the oral microbiota during this critical developmental period. Data also indicates that, while HIV infection clearly shapes the developing infant oral microbiome, the effect of perinatal exposure (without infection) appears transient.</description><subject>631/114</subject><subject>631/326</subject><subject>692/308/3187</subject><subject>692/4017</subject><subject>Age</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral therapy</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Community composition</subject><subject>Dental caries</subject><subject>Dental Caries - immunology</subject><subject>Dental Caries - microbiology</subject><subject>Dental disorders</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - microbiology</subject><subject>Human immunodeficiency virus</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immune status</subject><subject>Immunocompromised Host</subject><subject>Infections</subject><subject>Male</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>multidisciplinary</subject><subject>Perinatal exposure</subject><subject>rRNA 16S</subject><subject>Saliva</subject><subject>Saliva - microbiology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rFTEUhgdRbKn9Ay4k4MZFR_M1-dgIUtReKHRjuw2Z5EybMpNck8xF_72xt9bWhdkk5DznPR9v170m-D3BTH0onAxa9ZjiXkiuZM-fdYcU86GnjNLnj94H3XEpt7idgWpO9MvugFFBhKTysDObZVkjoFJtXcsJstGjmCo621yhECdwNaSIUkbwY5vKmuEE-Rx2UFC9AeRhB3PaLhArStPdV8p2RktwOY0hVfuqezHZucDx_X3UXX75_O30rD-_-Lo5_XTeOy557a2SYmJegxo944I5q4kDpUFIp6QWalLOEzWMzkvpxThqQSc3jNRapjGR7Kj7uNfdruMC3rWOWiNmm8Ni80-TbDBPIzHcmOu0M5KxtkjSBN7dC-T0fYVSzRKKg3m2EdJaDOUUk4FhzRr69h_0Nq05tvEaRfTQJiK0UXRPtVWUkmF6aIZg89tCs7fQNAvNnYWGt6Q3j8d4SPljWAPYHigtFK8h_639H9lfxG2n5g</recordid><startdate>20200702</startdate><enddate>20200702</enddate><creator>Coker, M. 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O.</au><au>Mongodin, E. F.</au><au>El-Kamary, S. S.</au><au>Akhigbe, P.</au><au>Obuekwe, O.</au><au>Omoigberale, A.</au><au>Langenberg, P.</au><au>Enwonwu, C.</au><au>Hittle, L.</au><au>Blattner, W. A.</au><au>Charurat, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune status, and not HIV infection or exposure, drives the development of the oral microbiota</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-07-02</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>10830</spage><epage>10830</epage><pages>10830-10830</pages><artnum>10830</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains unclear. We hypothesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children will significantly differ from HIV-unexposed-and-uninfected (HUU) children. Saliva samples from 286 child-participants in Nigeria, aged ≤ 6 years, were analyzed using 16S rRNA gene sequencing. Perinatal HIV infection was significantly associated with community composition (HI vs. HUU—p = 0.04; HEU vs. HUU—p = 0.11) however, immune status had stronger impacts on bacterial profiles (p < 0.001). We observed age-stratified associations of perinatal HIV exposure on community composition, with HEU children differing from HUU children in early life but HEU children becoming more similar to HUU children with age. Our findings suggest that, regardless of age, HIV infection or exposure, low CD4 levels persistently alter the oral microbiota during this critical developmental period. Data also indicates that, while HIV infection clearly shapes the developing infant oral microbiome, the effect of perinatal exposure (without infection) appears transient.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32616727</pmid><doi>10.1038/s41598-020-67487-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/114 631/326 692/308/3187 692/4017 Age Antiretroviral agents Antiretroviral therapy CD4 antigen CD4-Positive T-Lymphocytes - immunology Child Child, Preschool Children Community composition Dental caries Dental Caries - immunology Dental Caries - microbiology Dental disorders Female HIV HIV Infections - immunology HIV Infections - microbiology Human immunodeficiency virus Humanities and Social Sciences Humans Immune status Immunocompromised Host Infections Male Microbiomes Microbiota Microorganisms multidisciplinary Perinatal exposure rRNA 16S Saliva Saliva - microbiology Science Science (multidisciplinary) |
| title | Immune status, and not HIV infection or exposure, drives the development of the oral microbiota |
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