Solid immersion meniscus lens (SIMlens) for open-top light-sheet microscopy

Solid immersion meniscus lens (SIMlens) for open-top light-sheet microscopy

Open-top light-sheet (OTLS) microscopy has been developed for rapid volumetric imaging of large pathology specimens. A challenge with OTLS microscopy is the transmission of oblique illumination and detection beams through a horizontal sample plate without introducing aberrations. Previous solutions...

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Veröffentlicht in:Optics letters 2019-09, Vol.44 (18), p.4451-4454
Hauptverfasser: Barner, Lindsey A, Glaser, Adam K, True, Lawrence D, Reder, Nicholas P, Liu, Jonathan T C
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Sprache:eng
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Beams (structural)
Illumination
Microscopy
Refractivity
Submerging
Wave fronts
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container_issue 18
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container_title Optics letters
container_volume 44
creator Barner, Lindsey A
Glaser, Adam K
True, Lawrence D
Reder, Nicholas P
Liu, Jonathan T C
description Open-top light-sheet (OTLS) microscopy has been developed for rapid volumetric imaging of large pathology specimens. A challenge with OTLS microscopy is the transmission of oblique illumination and detection beams through a horizontal sample plate without introducing aberrations. Previous solutions prevented vertical sample movement, constrained the refractive index of the sample, and/or hindered multi-resolution imaging. Here we describe a solid immersion meniscus lens, a wavefront-matching element that suppresses aberrations when illumination and detection beam transition between air and various high-index immersion media, thereby enabling multi-resolution OTLS microscopy of specimens cleared with diverse protocols.
doi_str_mv 10.1364/OL.44.004451
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subjects Beams (structural)
Illumination
Microscopy
Refractivity
Submerging
Wave fronts
title Solid immersion meniscus lens (SIMlens) for open-top light-sheet microscopy
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