KRAS Mutation-Responsive miR-139-5p inhibits Colorectal Cancer Progression and is repressed by Wnt Signaling

Colorectal cancer (CRC) frequently harbors KRAS mutations that result in chemoresistance and metastasis. MicroRNAs (miRNAs) are usually dysregulated and play important regulatory roles in tumor progression. However, the KRAS mutation-responsive miRNA profile in CRC remains uninvestigated. miR-139-5p...

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Veröffentlicht in:	Theranostics 2020-01, Vol.10 (16), p.7335-7350
Hauptverfasser:	Du, Feng, Cao, Tianyu, Xie, Huahong, Li, Ting, Sun, Lina, Liu, Hao, Guo, Hao, Wang, Xin, Liu, Qi, Kim, Taewan, Franklin, Jeffrey L, Graves-Deal, Ramona, Han, Weili, Tian, Zuhong, Ge, Minghui, Nie, Yongzhan, Fan, Daiming, Coffey, Robert J, Lu, Yuanyuan, Zhao, Xiaodi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Binding sites Breast cancer Carcinogenesis - genetics Carcinogenesis - pathology Cell growth Cell Line, Tumor Cell Proliferation - genetics Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease Progression Epithelial-Mesenchymal Transition - genetics Feedback, Physiological Female Gene expression Gene Expression Regulation, Neoplastic Humans Infections Male Metastasis Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Mutation Neoplasm Invasiveness - genetics Plasmids Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Research Paper RNA-Seq Tissue Array Analysis Transcription, Genetic Wnt Signaling Pathway - genetics Xenograft Model Antitumor Assays
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