Characteristics of laboratory indexes in COVID-19 patients with non-severe symptoms in Hefei City, China: diagnostic value in organ injuries

This study compared the laboratory indexes in 40 non-severe COVID-19 patients with those in 57 healthy controls. In the peripheral blood system of non-severe symptom COVID-19 patients, lymphocytes, eosinophils, basophils, total procollagen type 1 amino-terminal propeptide, osteocalcin N-terminal, th...

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Veröffentlicht in:European journal of clinical microbiology & infectious diseases 2020-12, Vol.39 (12), p.2447-2455
Hauptverfasser: Li, Tao, Wang, Lianzi, Wang, Huihui, Gao, Yufeng, Hu, Xianwei, Li, Xuemei, Zhang, Shubing, Xu, Yuanhong, Wei, Wei
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container_issue 12
container_start_page 2447
container_title European journal of clinical microbiology & infectious diseases
container_volume 39
creator Li, Tao
Wang, Lianzi
Wang, Huihui
Gao, Yufeng
Hu, Xianwei
Li, Xuemei
Zhang, Shubing
Xu, Yuanhong
Wei, Wei
description This study compared the laboratory indexes in 40 non-severe COVID-19 patients with those in 57 healthy controls. In the peripheral blood system of non-severe symptom COVID-19 patients, lymphocytes, eosinophils, basophils, total procollagen type 1 amino-terminal propeptide, osteocalcin N-terminal, thyroid-stimulating hormone, growth hormone, and insulin-like growth factor–binding protein 3 significantly decreased, and total protein, albumin, alanine transaminase, alkaline phosphatase, γ-glutamyl transferase, activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer, fibrinogen degradation products, human epididymal protein 4, serum ferritin, and C-reactive protein were elevated. SARS-CoV-2 infection can affect hematopoiesis, hemostasis, coagulation, fibrinolysis, bone metabolism, thyroid, parathyroid glands, the liver, and the reproductive system.
doi_str_mv 10.1007/s10096-020-03967-9
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In the peripheral blood system of non-severe symptom COVID-19 patients, lymphocytes, eosinophils, basophils, total procollagen type 1 amino-terminal propeptide, osteocalcin N-terminal, thyroid-stimulating hormone, growth hormone, and insulin-like growth factor–binding protein 3 significantly decreased, and total protein, albumin, alanine transaminase, alkaline phosphatase, γ-glutamyl transferase, activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer, fibrinogen degradation products, human epididymal protein 4, serum ferritin, and C-reactive protein were elevated. SARS-CoV-2 infection can affect hematopoiesis, hemostasis, coagulation, fibrinolysis, bone metabolism, thyroid, parathyroid glands, the liver, and the reproductive system.</description><identifier>ISSN: 0934-9723</identifier><identifier>ISSN: 1435-4373</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-020-03967-9</identifier><identifier>PMID: 32613308</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Alanine ; Alanine transaminase ; Albumins ; Alkaline phosphatase ; Betacoronavirus - pathogenicity ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedical materials ; Biomedicine ; Bone and Bones - metabolism ; Bone and Bones - pathology ; Bone and Bones - virology ; Bone turnover ; Brief Report ; C-reactive protein ; C-Reactive Protein - metabolism ; Case-Control Studies ; China - epidemiology ; Coagulation ; Coronavirus Infections - blood ; Coronavirus Infections - diagnosis ; Coronavirus Infections - epidemiology ; Coronavirus Infections - pathology ; Coronaviruses ; COVID-19 ; Cross-Sectional Studies ; Degradation products ; Diagnostic systems ; Dimers ; Eosinophils ; Female ; Ferritin ; Ferritins - blood ; Fibrin Fibrinogen Degradation Products - metabolism ; Fibrinogen ; Fibrinolysis ; Growth factors ; Growth hormones ; Hematopoiesis ; Hemostasis ; Hemostatics ; Humans ; Insulin ; Internal Medicine ; Laboratories ; Leukocytes (basophilic) ; Leukocytes (eosinophilic) ; Liver - metabolism ; Liver - pathology ; Liver - virology ; Lymphocytes ; Male ; Medical Microbiology ; Middle Aged ; Osteocalcin ; Ovary - metabolism ; Ovary - pathology ; Ovary - virology ; Pandemics ; Parathyroid ; Parathyroid Glands - metabolism ; Parathyroid Glands - pathology ; Parathyroid Glands - virology ; Peripheral blood ; Pneumonia, Viral - blood ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - pathology ; Procollagen ; Proteins ; Prothrombin ; Reproductive system ; SARS-CoV-2 ; Serum Albumin - metabolism ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Testis - metabolism ; Testis - pathology ; Testis - virology ; Thromboplastin ; Thyroid ; Thyroid gland ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Thyroid Gland - virology ; Thyroid-stimulating hormone ; Viral diseases</subject><ispartof>European journal of clinical microbiology &amp; infectious diseases, 2020-12, Vol.39 (12), p.2447-2455</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-7e78fc711cfa5abd6a8d67e482a3a7d6149b1d596ec7c7c4580097f5fdb765c3</citedby><cites>FETCH-LOGICAL-c474t-7e78fc711cfa5abd6a8d67e482a3a7d6149b1d596ec7c7c4580097f5fdb765c3</cites><orcidid>0000-0003-3822-1856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-020-03967-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-020-03967-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32613308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Tao</creatorcontrib><creatorcontrib>Wang, Lianzi</creatorcontrib><creatorcontrib>Wang, Huihui</creatorcontrib><creatorcontrib>Gao, Yufeng</creatorcontrib><creatorcontrib>Hu, Xianwei</creatorcontrib><creatorcontrib>Li, Xuemei</creatorcontrib><creatorcontrib>Zhang, Shubing</creatorcontrib><creatorcontrib>Xu, Yuanhong</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><title>Characteristics of laboratory indexes in COVID-19 patients with non-severe symptoms in Hefei City, China: diagnostic value in organ injuries</title><title>European journal of clinical microbiology &amp; infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>This study compared the laboratory indexes in 40 non-severe COVID-19 patients with those in 57 healthy controls. In the peripheral blood system of non-severe symptom COVID-19 patients, lymphocytes, eosinophils, basophils, total procollagen type 1 amino-terminal propeptide, osteocalcin N-terminal, thyroid-stimulating hormone, growth hormone, and insulin-like growth factor–binding protein 3 significantly decreased, and total protein, albumin, alanine transaminase, alkaline phosphatase, γ-glutamyl transferase, activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer, fibrinogen degradation products, human epididymal protein 4, serum ferritin, and C-reactive protein were elevated. SARS-CoV-2 infection can affect hematopoiesis, hemostasis, coagulation, fibrinolysis, bone metabolism, thyroid, parathyroid glands, the liver, and the reproductive system.</description><subject>Adult</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Albumins</subject><subject>Alkaline phosphatase</subject><subject>Betacoronavirus - pathogenicity</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Bone and Bones - virology</subject><subject>Bone turnover</subject><subject>Brief Report</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Coagulation</subject><subject>Coronavirus Infections - blood</subject><subject>Coronavirus Infections - 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virology</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Osteocalcin</subject><subject>Ovary - metabolism</subject><subject>Ovary - pathology</subject><subject>Ovary - virology</subject><subject>Pandemics</subject><subject>Parathyroid</subject><subject>Parathyroid Glands - metabolism</subject><subject>Parathyroid Glands - pathology</subject><subject>Parathyroid Glands - virology</subject><subject>Peripheral blood</subject><subject>Pneumonia, Viral - blood</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - pathology</subject><subject>Procollagen</subject><subject>Proteins</subject><subject>Prothrombin</subject><subject>Reproductive system</subject><subject>SARS-CoV-2</subject><subject>Serum Albumin - metabolism</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Severity of Illness Index</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>Testis - virology</subject><subject>Thromboplastin</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Gland - virology</subject><subject>Thyroid-stimulating hormone</subject><subject>Viral diseases</subject><issn>0934-9723</issn><issn>1435-4373</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU2PFCEQhonRuOPoH_BgSLx4EIWmGxoPm5j2YzfZZC8br4Smq2eY9MAI9Oj8B3-0zM66fhyEhCLhqbeqeBF6zugbRql8m8qpBKEVJZQrIYl6gBas5g2pueQP0YIqXhMlK36GnqS0oSWplfIxOuOVYJzTdoF-dGsTjc0QXcrOJhxGPJk-RJNDPGDnB_gOqUTcXX-5_ECYwjuTHfic8DeX19gHTxLsIQJOh-0uh-0tfQEjONy5fHiNu7Xz5h0enFn5cKyC92aa4YiFuDK-XDZzdJCeokejmRI8u4tLdPPp4013Qa6uP19276-IrWWdiQTZjlYyZkfTmH4Qph2EhLqtDDdyEKxWPRsaJcDKsuumLf8kx2Yceikay5fo_CS7m_stDLYME82kd9FtTTzoYJz--8W7tV6FvZa8UpUQReDVnUAMX2dIWW9dsjBNxkOYk65qpkp7vKwlevkPuglz9GW6QkkmGK1UW6jqRNkYUoow3jfDqD56rU9e6-K1vvVaq5L04s8x7lN-mVsAfgJSefIriL9r_0f2J90Ktzs</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Li, Tao</creator><creator>Wang, Lianzi</creator><creator>Wang, Huihui</creator><creator>Gao, Yufeng</creator><creator>Hu, Xianwei</creator><creator>Li, Xuemei</creator><creator>Zhang, Shubing</creator><creator>Xu, Yuanhong</creator><creator>Wei, Wei</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3822-1856</orcidid></search><sort><creationdate>20201201</creationdate><title>Characteristics of laboratory indexes in COVID-19 patients with non-severe symptoms in Hefei City, China: diagnostic value in organ injuries</title><author>Li, Tao ; Wang, Lianzi ; Wang, Huihui ; Gao, Yufeng ; Hu, Xianwei ; Li, Xuemei ; Zhang, Shubing ; Xu, Yuanhong ; Wei, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-7e78fc711cfa5abd6a8d67e482a3a7d6149b1d596ec7c7c4580097f5fdb765c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Albumins</topic><topic>Alkaline phosphatase</topic><topic>Betacoronavirus - pathogenicity</topic><topic>Biomarkers - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical materials</topic><topic>Biomedicine</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - pathology</topic><topic>Bone and Bones - virology</topic><topic>Bone turnover</topic><topic>Brief Report</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Coagulation</topic><topic>Coronavirus Infections - blood</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronavirus Infections - pathology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cross-Sectional Studies</topic><topic>Degradation products</topic><topic>Diagnostic systems</topic><topic>Dimers</topic><topic>Eosinophils</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins - blood</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>Fibrinogen</topic><topic>Fibrinolysis</topic><topic>Growth factors</topic><topic>Growth hormones</topic><topic>Hematopoiesis</topic><topic>Hemostasis</topic><topic>Hemostatics</topic><topic>Humans</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Laboratories</topic><topic>Leukocytes (basophilic)</topic><topic>Leukocytes (eosinophilic)</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver - virology</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Middle Aged</topic><topic>Osteocalcin</topic><topic>Ovary - metabolism</topic><topic>Ovary - pathology</topic><topic>Ovary - virology</topic><topic>Pandemics</topic><topic>Parathyroid</topic><topic>Parathyroid Glands - metabolism</topic><topic>Parathyroid Glands - pathology</topic><topic>Parathyroid Glands - virology</topic><topic>Peripheral blood</topic><topic>Pneumonia, Viral - blood</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - 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In the peripheral blood system of non-severe symptom COVID-19 patients, lymphocytes, eosinophils, basophils, total procollagen type 1 amino-terminal propeptide, osteocalcin N-terminal, thyroid-stimulating hormone, growth hormone, and insulin-like growth factor–binding protein 3 significantly decreased, and total protein, albumin, alanine transaminase, alkaline phosphatase, γ-glutamyl transferase, activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer, fibrinogen degradation products, human epididymal protein 4, serum ferritin, and C-reactive protein were elevated. SARS-CoV-2 infection can affect hematopoiesis, hemostasis, coagulation, fibrinolysis, bone metabolism, thyroid, parathyroid glands, the liver, and the reproductive system.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32613308</pmid><doi>10.1007/s10096-020-03967-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3822-1856</orcidid><oa>free_for_read</oa></addata></record>
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ispartof European journal of clinical microbiology & infectious diseases, 2020-12, Vol.39 (12), p.2447-2455
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source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Adult
Alanine
Alanine transaminase
Albumins
Alkaline phosphatase
Betacoronavirus - pathogenicity
Biomarkers - blood
Biomedical and Life Sciences
Biomedical materials
Biomedicine
Bone and Bones - metabolism
Bone and Bones - pathology
Bone and Bones - virology
Bone turnover
Brief Report
C-reactive protein
C-Reactive Protein - metabolism
Case-Control Studies
China - epidemiology
Coagulation
Coronavirus Infections - blood
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
Coronavirus Infections - pathology
Coronaviruses
COVID-19
Cross-Sectional Studies
Degradation products
Diagnostic systems
Dimers
Eosinophils
Female
Ferritin
Ferritins - blood
Fibrin Fibrinogen Degradation Products - metabolism
Fibrinogen
Fibrinolysis
Growth factors
Growth hormones
Hematopoiesis
Hemostasis
Hemostatics
Humans
Insulin
Internal Medicine
Laboratories
Leukocytes (basophilic)
Leukocytes (eosinophilic)
Liver - metabolism
Liver - pathology
Liver - virology
Lymphocytes
Male
Medical Microbiology
Middle Aged
Osteocalcin
Ovary - metabolism
Ovary - pathology
Ovary - virology
Pandemics
Parathyroid
Parathyroid Glands - metabolism
Parathyroid Glands - pathology
Parathyroid Glands - virology
Peripheral blood
Pneumonia, Viral - blood
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - pathology
Procollagen
Proteins
Prothrombin
Reproductive system
SARS-CoV-2
Serum Albumin - metabolism
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Testis - metabolism
Testis - pathology
Testis - virology
Thromboplastin
Thyroid
Thyroid gland
Thyroid Gland - metabolism
Thyroid Gland - pathology
Thyroid Gland - virology
Thyroid-stimulating hormone
Viral diseases
title Characteristics of laboratory indexes in COVID-19 patients with non-severe symptoms in Hefei City, China: diagnostic value in organ injuries
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