Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia

: Advances in neonatal critical care have greatly improved the survival of preterm infants, but the long-term complications of prematurity, including bronchopulmonary dysplasia (BPD), cause mortality and morbidity later in life. Although VEGF (vascular endothelial growth factor) improves lung struct...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2020-07, Vol.202 (1), p.100-111
Hauptverfasser:	Bolte, Craig, Ustiyan, Vladimir, Ren, Xiaomeng, Dunn, Andrew W, Pradhan, Arun, Wang, Guolun, Kolesnichenko, Olena A, Deng, Zicheng, Zhang, Yufang, Shi, Donglu, Greenberg, James M, Jobe, Alan H, Kalin, Tanya V, Kalinichenko, Vladimir V
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inducing Agents - administration & dosage Angiogenesis Inducing Agents - pharmacology Angiogenesis Inducing Agents - therapeutic use Animals Animals, Newborn Blotting, Western Drug Delivery Systems Female Flow Cytometry Forkhead Box Protein M1 - administration & dosage Forkhead Box Protein M1 - pharmacology Forkhead Box Protein M1 - therapeutic use Forkhead Transcription Factors - administration & dosage Forkhead Transcription Factors - pharmacology Forkhead Transcription Factors - therapeutic use Hyperoxia Hyperoxia - drug therapy Hyperoxia - pathology Hyperoxia - physiopathology Injections, Intravenous Male Mice Mice, Inbred C57BL Microscopy, Confocal Nanoparticles Neonatal care Newborn babies Original Premature babies Pulmonary Alveoli - blood supply Pulmonary Alveoli - drug effects Pulmonary Alveoli - pathology Pulmonary Alveoli - physiopathology Reverse Transcriptase Polymerase Chain Reaction Transcription factors Treatment Outcome
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