Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial
Dransfield et al discuss a randomized clinical trial on the effect of Zephyr Endobronchial Valves on dyspnea, activity levels, and quality of life at one year. Bronchoscopic lung volume reduction with Zephyr Valves improves lung function, exercise tolerance, and quality of life of patients with hype...
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| Veröffentlicht in: | Annals of the American Thoracic Society 2020-07, Vol.17 (7), p.829-838 |
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| creator | Dransfield, Mark T. Garner, Justin L. Bhatt, Surya P. Slebos, Dirk-Jan Klooster, Karin Sciurba, Frank C. Shah, Pallav L. Marchetti, Nathaniel T. Sue, Richard D. Wright, Shawn Rivas-Perez, Hiram Wiese, Tanya A. Wahidi, Momen M. Goulart de Oliveira, Hugo Armstrong, Brian Radhakrishnan, Sri Shargill, Narinder S. Criner, Gerard J. Katz, Lewis Criner, Gerard J. Cordova, Francis Desai, Parag Marchetti, Nathaniel Kim, Victor Shenoy, Kartik Travaline, John Thomas, Jiji Criner, Lii-Yoong H. Sue, Richard Wright, Shawn Thornburg, Aaron Thomas, Terry Dransfield, Mark Bhatt, Surya Wells, James Michael Seabron-Harris, Necole Rivas-Perez, Hiram Gauhar, Umair Wiese, Tanya A. Despirito, Crissie Sciurba, Frank Bon Field, Jessica Chandra, Divay Leader, Joseph Semaan, Roy Ledezma, Christina Shah, Pallav Kemp, Samuel Garner, Justin Aboelhassan, Arafa Srikanthan, Karthi Tenda, Eric Abraham, Anita Sim, Cai Wahidi, Momen Mahmood, Kamran Shofer, Scott Coles, Kathleen de Oliveira, Hugo Goulart Oliveira, Guilherme Augusto Machado, Betina Benedetto, Igor Svartman, Fabio de Macedo Neto, Amarilio Schreiner, Leonardo Vieira, Taiane Morrissey, Brian Yoneda, Ken Tham, Tina Tompkins, Daniel Guerreiro Cardoso, Paulo F. Athanazio, Rodrigo Nominando, Felipe Rached, Samia Cassimiro, Luciana Hays, Steven Seeley, Eric Shrestha, Pavan Dincheva, Gabriela R. Majid, Adnan Alape-Moya, Daniel Parikh, Mihir Paton, Alichia Agnew, Alexis Pastis, Nicholas Strange, Charlie Beiko, Tatsiana Woodford, Danielle Blanton, Mary Kopas, Lisa Connolly, Timothy Santacruz, Jose Fernando Shah, Bhavin Vollenweider, Mark Herrera, Luis Khan, Rumi Sernulka, Kristine McFadden, P. Michael Barbers, Richard Hernandez, Michelle |
| description | Dransfield et al discuss a randomized clinical trial on the effect of Zephyr Endobronchial Valves on dyspnea, activity levels, and quality of life at one year. Bronchoscopic lung volume reduction with Zephyr Valves improves lung function, exercise tolerance, and quality of life of patients with hyperinflated emphysema and little to no collateral ventilation. Post hoc analysis of patient-reported outcomes (PROs), including multidimensional measures of dyspnea, activity, and quality of life, in the LIBERATE (Lung Function Improvement after Bronchoscopic Lung Volume Reduction with Pulmonx Endobronchial Valves used in Treatment of Emphysema) study are reported. The authors conclude that patients with severe hyperinflated emphysema achieving lung volume reductions with Zephyr Valves experience improvements in multidimensional scores for breathlessness, activity, and psychosocial parameters out to at least 12 months. |
| doi_str_mv | 10.1513/AnnalsATS.201909-666OC |
| format | Article |
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Results from a Randomized Clinical Trial</title><source>American Thoracic Society (ATS) Journals Online</source><source>Alma/SFX Local Collection</source><creator>Dransfield, Mark T. ; Garner, Justin L. ; Bhatt, Surya P. ; Slebos, Dirk-Jan ; Klooster, Karin ; Sciurba, Frank C. ; Shah, Pallav L. ; Marchetti, Nathaniel T. ; Sue, Richard D. ; Wright, Shawn ; Rivas-Perez, Hiram ; Wiese, Tanya A. ; Wahidi, Momen M. ; Goulart de Oliveira, Hugo ; Armstrong, Brian ; Radhakrishnan, Sri ; Shargill, Narinder S. ; Criner, Gerard J. ; Katz, Lewis ; Criner, Gerard J. ; Cordova, Francis ; Desai, Parag ; Marchetti, Nathaniel ; Kim, Victor ; Shenoy, Kartik ; Travaline, John ; Thomas, Jiji ; Criner, Lii-Yoong H. ; Sue, Richard ; Wright, Shawn ; Thornburg, Aaron ; Thomas, Terry ; Dransfield, Mark ; Bhatt, Surya ; Wells, James Michael ; Seabron-Harris, Necole ; Rivas-Perez, Hiram ; Gauhar, Umair ; Wiese, Tanya A. ; Despirito, Crissie ; Sciurba, Frank ; Bon Field, Jessica ; Chandra, Divay ; Leader, Joseph ; Semaan, Roy ; Ledezma, Christina ; Shah, Pallav ; Kemp, Samuel ; Garner, Justin ; Aboelhassan, Arafa ; Srikanthan, Karthi ; Tenda, Eric ; Abraham, Anita ; Sim, Cai ; Wahidi, Momen ; Mahmood, Kamran ; Shofer, Scott ; Coles, Kathleen ; de Oliveira, Hugo Goulart ; Oliveira, Guilherme Augusto ; Machado, Betina ; Benedetto, Igor ; Svartman, Fabio ; de Macedo Neto, Amarilio ; Schreiner, Leonardo ; Vieira, Taiane ; Morrissey, Brian ; Yoneda, Ken ; Tham, Tina ; Tompkins, Daniel ; Guerreiro Cardoso, Paulo F. ; Athanazio, Rodrigo ; Nominando, Felipe ; Rached, Samia ; Cassimiro, Luciana ; Hays, Steven ; Seeley, Eric ; Shrestha, Pavan ; Dincheva, Gabriela R. ; Majid, Adnan ; Alape-Moya, Daniel ; Parikh, Mihir ; Paton, Alichia ; Agnew, Alexis ; Pastis, Nicholas ; Strange, Charlie ; Beiko, Tatsiana ; Woodford, Danielle ; Blanton, Mary ; Kopas, Lisa ; Connolly, Timothy ; Santacruz, Jose Fernando ; Shah, Bhavin ; Vollenweider, Mark ; Herrera, Luis ; Khan, Rumi ; Sernulka, Kristine ; McFadden, P. Michael ; Barbers, Richard ; Hernandez, Michelle</creator><creatorcontrib>Dransfield, Mark T. ; Garner, Justin L. ; Bhatt, Surya P. ; Slebos, Dirk-Jan ; Klooster, Karin ; Sciurba, Frank C. ; Shah, Pallav L. ; Marchetti, Nathaniel T. ; Sue, Richard D. ; Wright, Shawn ; Rivas-Perez, Hiram ; Wiese, Tanya A. ; Wahidi, Momen M. ; Goulart de Oliveira, Hugo ; Armstrong, Brian ; Radhakrishnan, Sri ; Shargill, Narinder S. ; Criner, Gerard J. ; Katz, Lewis ; Criner, Gerard J. ; Cordova, Francis ; Desai, Parag ; Marchetti, Nathaniel ; Kim, Victor ; Shenoy, Kartik ; Travaline, John ; Thomas, Jiji ; Criner, Lii-Yoong H. ; Sue, Richard ; Wright, Shawn ; Thornburg, Aaron ; Thomas, Terry ; Dransfield, Mark ; Bhatt, Surya ; Wells, James Michael ; Seabron-Harris, Necole ; Rivas-Perez, Hiram ; Gauhar, Umair ; Wiese, Tanya A. ; Despirito, Crissie ; Sciurba, Frank ; Bon Field, Jessica ; Chandra, Divay ; Leader, Joseph ; Semaan, Roy ; Ledezma, Christina ; Shah, Pallav ; Kemp, Samuel ; Garner, Justin ; Aboelhassan, Arafa ; Srikanthan, Karthi ; Tenda, Eric ; Abraham, Anita ; Sim, Cai ; Wahidi, Momen ; Mahmood, Kamran ; Shofer, Scott ; Coles, Kathleen ; de Oliveira, Hugo Goulart ; Oliveira, Guilherme Augusto ; Machado, Betina ; Benedetto, Igor ; Svartman, Fabio ; de Macedo Neto, Amarilio ; Schreiner, Leonardo ; Vieira, Taiane ; Morrissey, Brian ; Yoneda, Ken ; Tham, Tina ; Tompkins, Daniel ; Guerreiro Cardoso, Paulo F. ; Athanazio, Rodrigo ; Nominando, Felipe ; Rached, Samia ; Cassimiro, Luciana ; Hays, Steven ; Seeley, Eric ; Shrestha, Pavan ; Dincheva, Gabriela R. ; Majid, Adnan ; Alape-Moya, Daniel ; Parikh, Mihir ; Paton, Alichia ; Agnew, Alexis ; Pastis, Nicholas ; Strange, Charlie ; Beiko, Tatsiana ; Woodford, Danielle ; Blanton, Mary ; Kopas, Lisa ; Connolly, Timothy ; Santacruz, Jose Fernando ; Shah, Bhavin ; Vollenweider, Mark ; Herrera, Luis ; Khan, Rumi ; Sernulka, Kristine ; McFadden, P. Michael ; Barbers, Richard ; Hernandez, Michelle</creatorcontrib><description>Dransfield et al discuss a randomized clinical trial on the effect of Zephyr Endobronchial Valves on dyspnea, activity levels, and quality of life at one year. Bronchoscopic lung volume reduction with Zephyr Valves improves lung function, exercise tolerance, and quality of life of patients with hyperinflated emphysema and little to no collateral ventilation. Post hoc analysis of patient-reported outcomes (PROs), including multidimensional measures of dyspnea, activity, and quality of life, in the LIBERATE (Lung Function Improvement after Bronchoscopic Lung Volume Reduction with Pulmonx Endobronchial Valves used in Treatment of Emphysema) study are reported. The authors conclude that patients with severe hyperinflated emphysema achieving lung volume reductions with Zephyr Valves experience improvements in multidimensional scores for breathlessness, activity, and psychosocial parameters out to at least 12 months.</description><identifier>ISSN: 2329-6933</identifier><identifier>EISSN: 2325-6621</identifier><identifier>DOI: 10.1513/AnnalsATS.201909-666OC</identifier><identifier>PMID: 32223724</identifier><language>eng</language><publisher>New York: American Thoracic Society</publisher><subject>Clinical trials ; Lung cancer ; Original Research ; Quality of life ; Surgical outcomes ; Thoracic surgery</subject><ispartof>Annals of the American Thoracic Society, 2020-07, Vol.17 (7), p.829-838</ispartof><rights>Copyright American Thoracic Society Jul 2020</rights><rights>Copyright © 2020 by the American Thoracic Society 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Danielle</creatorcontrib><creatorcontrib>Blanton, Mary</creatorcontrib><creatorcontrib>Kopas, Lisa</creatorcontrib><creatorcontrib>Connolly, Timothy</creatorcontrib><creatorcontrib>Santacruz, Jose Fernando</creatorcontrib><creatorcontrib>Shah, Bhavin</creatorcontrib><creatorcontrib>Vollenweider, Mark</creatorcontrib><creatorcontrib>Herrera, Luis</creatorcontrib><creatorcontrib>Khan, Rumi</creatorcontrib><creatorcontrib>Sernulka, Kristine</creatorcontrib><creatorcontrib>McFadden, P. Michael</creatorcontrib><creatorcontrib>Barbers, Richard</creatorcontrib><creatorcontrib>Hernandez, Michelle</creatorcontrib><title>Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial</title><title>Annals of the American Thoracic Society</title><description>Dransfield et al discuss a randomized clinical trial on the effect of Zephyr Endobronchial Valves on dyspnea, activity levels, and quality of life at one year. Bronchoscopic lung volume reduction with Zephyr Valves improves lung function, exercise tolerance, and quality of life of patients with hyperinflated emphysema and little to no collateral ventilation. Post hoc analysis of patient-reported outcomes (PROs), including multidimensional measures of dyspnea, activity, and quality of life, in the LIBERATE (Lung Function Improvement after Bronchoscopic Lung Volume Reduction with Pulmonx Endobronchial Valves used in Treatment of Emphysema) study are reported. The authors conclude that patients with severe hyperinflated emphysema achieving lung volume reductions with Zephyr Valves experience improvements in multidimensional scores for breathlessness, activity, and psychosocial parameters out to at least 12 months.</description><subject>Clinical trials</subject><subject>Lung cancer</subject><subject>Original Research</subject><subject>Quality of life</subject><subject>Surgical outcomes</subject><subject>Thoracic surgery</subject><issn>2329-6933</issn><issn>2325-6621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkd-KEzEUxoMo7rLuK0jAGy-2dZJMZpIbodT6BwrFtQp6EzKZE5slk9RkplCfwYc23S4LmpuTnPOd7-TwQ-glqeaEE_ZmEYL2ebH9MqcVkZWcNU2zWT5Bl5RRXh6UPL2_l4Jk7AJd53xXlSM4Ea18ji4YpZS1tL5Ef1bWghlxtPgH7HfHhFehj12Kweyc9vib9gfIOAb87pj3AfQNXpjRHdx4xGs4gM83WIcef560P-WKz9pZwHrEmwD4O-g0x7eQJz9mbFMcsMa3pSEO7jf0eOldcKbM2aYy7QV6ZsticP0Qr9DX96vt8uNsvfnwablYz0xN5DizUAvgLVguGe9a3neS8lZqIjvBO9tQwcBUgvQStOWd4bQzhsmeE9vp1tbsCr09--6nboDeQBiT9mqf3KDTUUXt1L-V4HbqZzyollFBBCsGrx8MUvw1QR7V4LIB73WAOGVFmahFXXNKivTVf9K7OKUTP0XLNi0nFa-KqjmrTIo5J7CPnyGVOjFXj8zVmbm6Z87-AlDlod4</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Dransfield, Mark T.</creator><creator>Garner, Justin L.</creator><creator>Bhatt, Surya P.</creator><creator>Slebos, Dirk-Jan</creator><creator>Klooster, Karin</creator><creator>Sciurba, Frank C.</creator><creator>Shah, Pallav L.</creator><creator>Marchetti, Nathaniel T.</creator><creator>Sue, Richard D.</creator><creator>Wright, Shawn</creator><creator>Rivas-Perez, Hiram</creator><creator>Wiese, Tanya A.</creator><creator>Wahidi, Momen M.</creator><creator>Goulart de Oliveira, Hugo</creator><creator>Armstrong, Brian</creator><creator>Radhakrishnan, Sri</creator><creator>Shargill, Narinder S.</creator><creator>Criner, Gerard J.</creator><creator>Katz, Lewis</creator><creator>Criner, Gerard J.</creator><creator>Cordova, Francis</creator><creator>Desai, Parag</creator><creator>Marchetti, Nathaniel</creator><creator>Kim, Victor</creator><creator>Shenoy, Kartik</creator><creator>Travaline, John</creator><creator>Thomas, Jiji</creator><creator>Criner, Lii-Yoong H.</creator><creator>Sue, Richard</creator><creator>Wright, Shawn</creator><creator>Thornburg, Aaron</creator><creator>Thomas, Terry</creator><creator>Dransfield, Mark</creator><creator>Bhatt, Surya</creator><creator>Wells, James Michael</creator><creator>Seabron-Harris, Necole</creator><creator>Rivas-Perez, Hiram</creator><creator>Gauhar, Umair</creator><creator>Wiese, Tanya A.</creator><creator>Despirito, Crissie</creator><creator>Sciurba, Frank</creator><creator>Bon Field, Jessica</creator><creator>Chandra, Divay</creator><creator>Leader, Joseph</creator><creator>Semaan, Roy</creator><creator>Ledezma, Christina</creator><creator>Shah, Pallav</creator><creator>Kemp, Samuel</creator><creator>Garner, Justin</creator><creator>Aboelhassan, Arafa</creator><creator>Srikanthan, Karthi</creator><creator>Tenda, Eric</creator><creator>Abraham, Anita</creator><creator>Sim, Cai</creator><creator>Wahidi, Momen</creator><creator>Mahmood, Kamran</creator><creator>Shofer, Scott</creator><creator>Coles, Kathleen</creator><creator>de Oliveira, Hugo Goulart</creator><creator>Oliveira, Guilherme Augusto</creator><creator>Machado, Betina</creator><creator>Benedetto, Igor</creator><creator>Svartman, Fabio</creator><creator>de Macedo Neto, Amarilio</creator><creator>Schreiner, Leonardo</creator><creator>Vieira, Taiane</creator><creator>Morrissey, Brian</creator><creator>Yoneda, Ken</creator><creator>Tham, Tina</creator><creator>Tompkins, Daniel</creator><creator>Guerreiro Cardoso, Paulo F.</creator><creator>Athanazio, Rodrigo</creator><creator>Nominando, Felipe</creator><creator>Rached, Samia</creator><creator>Cassimiro, Luciana</creator><creator>Hays, Steven</creator><creator>Seeley, Eric</creator><creator>Shrestha, Pavan</creator><creator>Dincheva, Gabriela R.</creator><creator>Majid, Adnan</creator><creator>Alape-Moya, Daniel</creator><creator>Parikh, Mihir</creator><creator>Paton, Alichia</creator><creator>Agnew, Alexis</creator><creator>Pastis, Nicholas</creator><creator>Strange, Charlie</creator><creator>Beiko, Tatsiana</creator><creator>Woodford, Danielle</creator><creator>Blanton, Mary</creator><creator>Kopas, Lisa</creator><creator>Connolly, Timothy</creator><creator>Santacruz, Jose Fernando</creator><creator>Shah, Bhavin</creator><creator>Vollenweider, Mark</creator><creator>Herrera, Luis</creator><creator>Khan, Rumi</creator><creator>Sernulka, Kristine</creator><creator>McFadden, P. Michael</creator><creator>Barbers, Richard</creator><creator>Hernandez, Michelle</creator><general>American Thoracic Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9052-4638</orcidid></search><sort><creationdate>20200701</creationdate><title>Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial</title><author>Dransfield, Mark T. ; Garner, Justin L. ; Bhatt, Surya P. ; Slebos, Dirk-Jan ; Klooster, Karin ; Sciurba, Frank C. ; Shah, Pallav L. ; Marchetti, Nathaniel T. ; Sue, Richard D. ; Wright, Shawn ; Rivas-Perez, Hiram ; Wiese, Tanya A. ; Wahidi, Momen M. ; Goulart de Oliveira, Hugo ; Armstrong, Brian ; Radhakrishnan, Sri ; Shargill, Narinder S. ; Criner, Gerard J. ; Katz, Lewis ; Criner, Gerard J. ; Cordova, Francis ; Desai, Parag ; Marchetti, Nathaniel ; Kim, Victor ; Shenoy, Kartik ; Travaline, John ; Thomas, Jiji ; Criner, Lii-Yoong H. ; Sue, Richard ; Wright, Shawn ; Thornburg, Aaron ; Thomas, Terry ; Dransfield, Mark ; Bhatt, Surya ; Wells, James Michael ; Seabron-Harris, Necole ; Rivas-Perez, Hiram ; Gauhar, Umair ; Wiese, Tanya A. ; Despirito, Crissie ; Sciurba, Frank ; Bon Field, Jessica ; Chandra, Divay ; Leader, Joseph ; Semaan, Roy ; Ledezma, Christina ; Shah, Pallav ; Kemp, Samuel ; Garner, Justin ; Aboelhassan, Arafa ; Srikanthan, Karthi ; Tenda, Eric ; Abraham, Anita ; Sim, Cai ; Wahidi, Momen ; Mahmood, Kamran ; Shofer, Scott ; Coles, Kathleen ; de Oliveira, Hugo Goulart ; Oliveira, Guilherme Augusto ; Machado, Betina ; Benedetto, Igor ; Svartman, Fabio ; de Macedo Neto, Amarilio ; Schreiner, Leonardo ; Vieira, Taiane ; Morrissey, Brian ; Yoneda, Ken ; Tham, Tina ; Tompkins, Daniel ; Guerreiro Cardoso, Paulo F. ; Athanazio, Rodrigo ; Nominando, Felipe ; Rached, Samia ; Cassimiro, Luciana ; Hays, Steven ; Seeley, Eric ; Shrestha, Pavan ; Dincheva, Gabriela R. ; Majid, Adnan ; Alape-Moya, Daniel ; Parikh, Mihir ; Paton, Alichia ; Agnew, Alexis ; Pastis, Nicholas ; Strange, Charlie ; Beiko, Tatsiana ; Woodford, Danielle ; Blanton, Mary ; Kopas, Lisa ; Connolly, Timothy ; Santacruz, Jose Fernando ; Shah, Bhavin ; Vollenweider, Mark ; Herrera, Luis ; Khan, Rumi ; Sernulka, Kristine ; McFadden, P. 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Michael</creatorcontrib><creatorcontrib>Barbers, Richard</creatorcontrib><creatorcontrib>Hernandez, Michelle</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the American Thoracic Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dransfield, Mark T.</au><au>Garner, Justin L.</au><au>Bhatt, Surya P.</au><au>Slebos, Dirk-Jan</au><au>Klooster, Karin</au><au>Sciurba, Frank C.</au><au>Shah, Pallav L.</au><au>Marchetti, Nathaniel T.</au><au>Sue, Richard D.</au><au>Wright, Shawn</au><au>Rivas-Perez, Hiram</au><au>Wiese, Tanya A.</au><au>Wahidi, Momen M.</au><au>Goulart de Oliveira, Hugo</au><au>Armstrong, Brian</au><au>Radhakrishnan, Sri</au><au>Shargill, Narinder S.</au><au>Criner, Gerard J.</au><au>Katz, Lewis</au><au>Criner, Gerard J.</au><au>Cordova, Francis</au><au>Desai, Parag</au><au>Marchetti, Nathaniel</au><au>Kim, Victor</au><au>Shenoy, Kartik</au><au>Travaline, John</au><au>Thomas, Jiji</au><au>Criner, Lii-Yoong H.</au><au>Sue, Richard</au><au>Wright, Shawn</au><au>Thornburg, Aaron</au><au>Thomas, Terry</au><au>Dransfield, Mark</au><au>Bhatt, Surya</au><au>Wells, James Michael</au><au>Seabron-Harris, Necole</au><au>Rivas-Perez, Hiram</au><au>Gauhar, Umair</au><au>Wiese, Tanya A.</au><au>Despirito, Crissie</au><au>Sciurba, Frank</au><au>Bon Field, Jessica</au><au>Chandra, Divay</au><au>Leader, Joseph</au><au>Semaan, Roy</au><au>Ledezma, Christina</au><au>Shah, Pallav</au><au>Kemp, Samuel</au><au>Garner, Justin</au><au>Aboelhassan, Arafa</au><au>Srikanthan, Karthi</au><au>Tenda, Eric</au><au>Abraham, Anita</au><au>Sim, Cai</au><au>Wahidi, Momen</au><au>Mahmood, Kamran</au><au>Shofer, Scott</au><au>Coles, Kathleen</au><au>de Oliveira, Hugo Goulart</au><au>Oliveira, Guilherme Augusto</au><au>Machado, Betina</au><au>Benedetto, Igor</au><au>Svartman, Fabio</au><au>de Macedo Neto, Amarilio</au><au>Schreiner, Leonardo</au><au>Vieira, Taiane</au><au>Morrissey, Brian</au><au>Yoneda, Ken</au><au>Tham, Tina</au><au>Tompkins, Daniel</au><au>Guerreiro Cardoso, Paulo F.</au><au>Athanazio, Rodrigo</au><au>Nominando, Felipe</au><au>Rached, Samia</au><au>Cassimiro, Luciana</au><au>Hays, Steven</au><au>Seeley, Eric</au><au>Shrestha, Pavan</au><au>Dincheva, Gabriela R.</au><au>Majid, Adnan</au><au>Alape-Moya, Daniel</au><au>Parikh, Mihir</au><au>Paton, Alichia</au><au>Agnew, Alexis</au><au>Pastis, Nicholas</au><au>Strange, Charlie</au><au>Beiko, Tatsiana</au><au>Woodford, Danielle</au><au>Blanton, Mary</au><au>Kopas, Lisa</au><au>Connolly, Timothy</au><au>Santacruz, Jose Fernando</au><au>Shah, Bhavin</au><au>Vollenweider, Mark</au><au>Herrera, Luis</au><au>Khan, Rumi</au><au>Sernulka, Kristine</au><au>McFadden, P. Michael</au><au>Barbers, Richard</au><au>Hernandez, Michelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial</atitle><jtitle>Annals of the American Thoracic Society</jtitle><date>2020-07-01</date><risdate>2020</risdate><volume>17</volume><issue>7</issue><spage>829</spage><epage>838</epage><pages>829-838</pages><issn>2329-6933</issn><eissn>2325-6621</eissn><abstract>Dransfield et al discuss a randomized clinical trial on the effect of Zephyr Endobronchial Valves on dyspnea, activity levels, and quality of life at one year. Bronchoscopic lung volume reduction with Zephyr Valves improves lung function, exercise tolerance, and quality of life of patients with hyperinflated emphysema and little to no collateral ventilation. Post hoc analysis of patient-reported outcomes (PROs), including multidimensional measures of dyspnea, activity, and quality of life, in the LIBERATE (Lung Function Improvement after Bronchoscopic Lung Volume Reduction with Pulmonx Endobronchial Valves used in Treatment of Emphysema) study are reported. The authors conclude that patients with severe hyperinflated emphysema achieving lung volume reductions with Zephyr Valves experience improvements in multidimensional scores for breathlessness, activity, and psychosocial parameters out to at least 12 months.</abstract><cop>New York</cop><pub>American Thoracic Society</pub><pmid>32223724</pmid><doi>10.1513/AnnalsATS.201909-666OC</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9052-4638</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2329-6933 |
| ispartof | Annals of the American Thoracic Society, 2020-07, Vol.17 (7), p.829-838 |
| issn | 2329-6933 2325-6621 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7328183 |
| source | American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Clinical trials Lung cancer Original Research Quality of life Surgical outcomes Thoracic surgery |
| title | Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial |
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