A novel approach to measure mitochondrial respiration in frozen biological samples

Respirometry is the gold standard measurement of mitochondrial oxidative function, as it reflects the activity of the electron transport chain complexes working together. However, the requirement for freshly isolated mitochondria hinders the feasibility of respirometry in multi‐site clinical studies...

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Veröffentlicht in:	The EMBO journal 2020-07, Vol.39 (13), p.e104073-n/a
Hauptverfasser:	Acin‐Perez, Rebeca, Benador, Ilan Y, Petcherski, Anton, Veliova, Michaela, Benavides, Gloria A, Lagarrigue, Sylviane, Caudal, Arianne, Vergnes, Laurent, Murphy, Anne N, Karamanlidis, Georgios, Tian, Rong, Reue, Karen, Wanagat, Jonathan, Sacks, Harold, Amati, Francesca, Darley‐Usmar, Victor M, Liesa, Marc, Divakaruni, Ajit S, Stiles, Linsey, Shirihai, Orian S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioenergetics Biological properties Biological samples Cryopreservation Electron transfer Electron transport Electron transport chain Electron Transport Chain Complex Proteins - metabolism EMBO20 EMBO22 EMBO57 Freeze-thawing frozen tissue Lysates Male Membranes methodology Mice Mitochondria Mitochondria - metabolism mitochondrial content mitochondrial uncoupled respiration Oxygen Consumption Resource Resources Respiration Respiratory rate Respirometry Thawing Tissues Toxicity Zebrafish - metabolism Zebrafish Proteins - metabolism
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