Prevalence of Sjögren’s syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
To estimate the prevalence of Sjögren’s syndrome (SS) in the adult Spanish population we performed a population-based multicenter cross-sectional study. Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were include...
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| Veröffentlicht in: | Scientific reports 2020-06, Vol.10 (1), p.10627-10627, Article 10627 |
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| description | To estimate the prevalence of Sjögren’s syndrome (SS) in the adult Spanish population we performed a population-based multicenter cross-sectional study. Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were included. The estimated prevalence of SS (including primary and secondary forms) in the adult population in Spain was 0.33% (95% CI 0.21–0.53). Extrapolating to the total population of the country aged ≥ 20 years (around 37.7 million persons), there would be around 125,000 cases of SS in Spain. Considering only primary SS, the estimated prevalence was 0.25% (95% CI 0.15–0.43) or 1 person in 400. The prevalence of primary SS in Spain is comparable to that reported in other European studies with a similar design and diagnostic criteria. Based on these results, primary SS could not be considered a rare (orphan) disease. Only 50% of cases had already been diagnosed with SS prior EPISER 2016 study, confirming the existence of a non-negligible proportion of undiagnosed cases in the general population. |
| doi_str_mv | 10.1038/s41598-020-67462-z |
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Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were included. The estimated prevalence of SS (including primary and secondary forms) in the adult population in Spain was 0.33% (95% CI 0.21–0.53). Extrapolating to the total population of the country aged ≥ 20 years (around 37.7 million persons), there would be around 125,000 cases of SS in Spain. Considering only primary SS, the estimated prevalence was 0.25% (95% CI 0.15–0.43) or 1 person in 400. The prevalence of primary SS in Spain is comparable to that reported in other European studies with a similar design and diagnostic criteria. Based on these results, primary SS could not be considered a rare (orphan) disease. Only 50% of cases had already been diagnosed with SS prior EPISER 2016 study, confirming the existence of a non-negligible proportion of undiagnosed cases in the general population.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-67462-z</identifier><identifier>PMID: 32606345</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/4023 ; 692/4023/1670 ; 692/700/1538 ; Adult ; Female ; Humanities and Social Sciences ; Humans ; Male ; Middle Aged ; multidisciplinary ; Population ; Population studies ; Prevalence ; Science ; Science (multidisciplinary) ; Sjogren's syndrome ; Sjogren's Syndrome - diagnosis ; Sjogren's Syndrome - epidemiology ; Spain ; Undiagnosed Diseases - epidemiology</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.10627-10627, Article 10627</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were included. The estimated prevalence of SS (including primary and secondary forms) in the adult population in Spain was 0.33% (95% CI 0.21–0.53). Extrapolating to the total population of the country aged ≥ 20 years (around 37.7 million persons), there would be around 125,000 cases of SS in Spain. Considering only primary SS, the estimated prevalence was 0.25% (95% CI 0.15–0.43) or 1 person in 400. The prevalence of primary SS in Spain is comparable to that reported in other European studies with a similar design and diagnostic criteria. Based on these results, primary SS could not be considered a rare (orphan) disease. Only 50% of cases had already been diagnosed with SS prior EPISER 2016 study, confirming the existence of a non-negligible proportion of undiagnosed cases in the general population.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32606345</pmid><doi>10.1038/s41598-020-67462-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1614-8064</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/174 692/4023 692/4023/1670 692/700/1538 Adult Female Humanities and Social Sciences Humans Male Middle Aged multidisciplinary Population Population studies Prevalence Science Science (multidisciplinary) Sjogren's syndrome Sjogren's Syndrome - diagnosis Sjogren's Syndrome - epidemiology Spain Undiagnosed Diseases - epidemiology |
| title | Prevalence of Sjögren’s syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases |
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