Systemic Inonotus sp. Infection in a dog
A 3-years-old male golden retriever was presented for decreased activity (lethargy), anorexia, and titubation. Superficial lymph nodes were enlarged, and arrhythmia and tachycardia were auscultated. Fungal hyphae-like structures were detected in the biopsy samples from an enlarged lymph node and spl...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2020, Vol.82(6), pp.779-783 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | FURUSAWA, Yu TAKAHASHI, Masashi IWANAGA, Tomoko YABUKI, Akira KANO, Rui HATAI, Hitoshi SUENO, Wako ENDO, Yasuyuki MOMOI, Yasuyuki |
| description | A 3-years-old male golden retriever was presented for decreased activity (lethargy), anorexia, and titubation. Superficial lymph nodes were enlarged, and arrhythmia and tachycardia were auscultated. Fungal hyphae-like structures were detected in the biopsy samples from an enlarged lymph node and spleen. Nucleotide sequence of the internal transcribed spacer region of the fungi amplified by PCR was highly homologous to that of Inonotus pachyphloeus. The dog was treated with antifungal agents such as itraconazole, fluconazole, and voriconazole. Clinical signs resolved for 325 days but the dog died suddenly, possibly because of arrhythmia. Postmortem examination revealed the presence of a disseminated fungal infection. This report describes the case of canine systemic Inonotus sp. infection treated by an antifungal agent. |
| doi_str_mv | 10.1292/jvms.19-0455 |
| format | Article |
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Infection in a dog</title><source>J-STAGE Free</source><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>FURUSAWA, Yu ; TAKAHASHI, Masashi ; IWANAGA, Tomoko ; YABUKI, Akira ; KANO, Rui ; HATAI, Hitoshi ; SUENO, Wako ; ENDO, Yasuyuki ; MOMOI, Yasuyuki</creator><creatorcontrib>FURUSAWA, Yu ; TAKAHASHI, Masashi ; IWANAGA, Tomoko ; YABUKI, Akira ; KANO, Rui ; HATAI, Hitoshi ; SUENO, Wako ; ENDO, Yasuyuki ; MOMOI, Yasuyuki</creatorcontrib><description>A 3-years-old male golden retriever was presented for decreased activity (lethargy), anorexia, and titubation. Superficial lymph nodes were enlarged, and arrhythmia and tachycardia were auscultated. Fungal hyphae-like structures were detected in the biopsy samples from an enlarged lymph node and spleen. Nucleotide sequence of the internal transcribed spacer region of the fungi amplified by PCR was highly homologous to that of Inonotus pachyphloeus. The dog was treated with antifungal agents such as itraconazole, fluconazole, and voriconazole. Clinical signs resolved for 325 days but the dog died suddenly, possibly because of arrhythmia. Postmortem examination revealed the presence of a disseminated fungal infection. This report describes the case of canine systemic Inonotus sp. infection treated by an antifungal agent.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.19-0455</identifier><identifier>PMID: 32378518</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; Anorexia ; antifungal agent ; Antifungal agents ; Antifungal Agents - therapeutic use ; Arrhythmia ; Arrhythmias, Cardiac - veterinary ; Biopsy ; Cardiac arrhythmia ; DNA, Fungal ; DNA, Ribosomal Spacer ; dog ; Dog Diseases - diagnosis ; Dog Diseases - drug therapy ; Dog Diseases - microbiology ; Dogs ; Fluconazole ; Fungi ; Hyphae ; Infections ; Inonotus - drug effects ; Inonotus - genetics ; Inonotus - isolation & purification ; Inonotus sp ; Internal Medicine ; Itraconazole ; Lymph nodes ; Male ; Mycoses - diagnosis ; Mycoses - drug therapy ; Mycoses - microbiology ; Mycoses - veterinary ; Nucleotide sequence ; Polymerase Chain Reaction ; Spacer region ; Spleen ; systemic mycosis ; Tachycardia ; Tachycardia - veterinary ; Voriconazole</subject><ispartof>Journal of Veterinary Medical Science, 2020, Vol.82(6), pp.779-783</ispartof><rights>2020 by the Japanese Society of Veterinary Science</rights><rights>2020. 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Infection in a dog</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>A 3-years-old male golden retriever was presented for decreased activity (lethargy), anorexia, and titubation. Superficial lymph nodes were enlarged, and arrhythmia and tachycardia were auscultated. Fungal hyphae-like structures were detected in the biopsy samples from an enlarged lymph node and spleen. Nucleotide sequence of the internal transcribed spacer region of the fungi amplified by PCR was highly homologous to that of Inonotus pachyphloeus. The dog was treated with antifungal agents such as itraconazole, fluconazole, and voriconazole. Clinical signs resolved for 325 days but the dog died suddenly, possibly because of arrhythmia. Postmortem examination revealed the presence of a disseminated fungal infection. This report describes the case of canine systemic Inonotus sp. infection treated by an antifungal agent.</description><subject>Animals</subject><subject>Anorexia</subject><subject>antifungal agent</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Arrhythmia</subject><subject>Arrhythmias, Cardiac - veterinary</subject><subject>Biopsy</subject><subject>Cardiac arrhythmia</subject><subject>DNA, Fungal</subject><subject>DNA, Ribosomal Spacer</subject><subject>dog</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - drug therapy</subject><subject>Dog Diseases - microbiology</subject><subject>Dogs</subject><subject>Fluconazole</subject><subject>Fungi</subject><subject>Hyphae</subject><subject>Infections</subject><subject>Inonotus - drug effects</subject><subject>Inonotus - genetics</subject><subject>Inonotus - isolation & purification</subject><subject>Inonotus sp</subject><subject>Internal Medicine</subject><subject>Itraconazole</subject><subject>Lymph nodes</subject><subject>Male</subject><subject>Mycoses - diagnosis</subject><subject>Mycoses - drug therapy</subject><subject>Mycoses - microbiology</subject><subject>Mycoses - veterinary</subject><subject>Nucleotide sequence</subject><subject>Polymerase Chain Reaction</subject><subject>Spacer region</subject><subject>Spleen</subject><subject>systemic mycosis</subject><subject>Tachycardia</subject><subject>Tachycardia - veterinary</subject><subject>Voriconazole</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9LwzAUx4MoOqc3z1LwsoOdefnV5iKo-AsED-o5pDHdOtpkJu1g_70tm0O95BHehw_vvS9CZ4CnQCS5WqyaOAWZYsb5HhoBZVmaMSr30QhLEGlGOD5CxzEuMCbAhDxER5TQLOeQj9DkbR1b21QmeXbe-baLSVxO-09pTVt5l1Qu0cmnn52gg1LX0Z5u6xh9PNy_3z2lL6-Pz3c3L6kRINsUOCZZIQvLgBIuNUigglnJAQgWVMisKDQxpSg0ZRgby5gwpQFeciiskXSMrjfeZVc09tNY1wZdq2WoGh3WyutK_e24aq5mfqUySlgOohdMtoLgvzobW9VU0di61s76LipCpcz7-3Do0Yt_6MJ3wfXrKcJAMsEFGajLDWWCjzHYcjcMYDVEoIYIFEg1RNDj578X2ME_N--B2w2wiK2e2R2gQ1uZ2m5sOVFieLbWXdPMdVDW0W8SqphK</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>FURUSAWA, Yu</creator><creator>TAKAHASHI, Masashi</creator><creator>IWANAGA, Tomoko</creator><creator>YABUKI, Akira</creator><creator>KANO, Rui</creator><creator>HATAI, Hitoshi</creator><creator>SUENO, Wako</creator><creator>ENDO, Yasuyuki</creator><creator>MOMOI, Yasuyuki</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Veterinary Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2020</creationdate><title>Systemic Inonotus sp. Infection in a dog</title><author>FURUSAWA, Yu ; TAKAHASHI, Masashi ; IWANAGA, Tomoko ; YABUKI, Akira ; KANO, Rui ; HATAI, Hitoshi ; SUENO, Wako ; ENDO, Yasuyuki ; MOMOI, Yasuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-15027b9be413259a191364e95112063697bba2cf6ba3400ce446cfc15f51bec93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Anorexia</topic><topic>antifungal agent</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Arrhythmia</topic><topic>Arrhythmias, Cardiac - veterinary</topic><topic>Biopsy</topic><topic>Cardiac arrhythmia</topic><topic>DNA, Fungal</topic><topic>DNA, Ribosomal Spacer</topic><topic>dog</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - drug therapy</topic><topic>Dog Diseases - microbiology</topic><topic>Dogs</topic><topic>Fluconazole</topic><topic>Fungi</topic><topic>Hyphae</topic><topic>Infections</topic><topic>Inonotus - drug effects</topic><topic>Inonotus - genetics</topic><topic>Inonotus - isolation & purification</topic><topic>Inonotus sp</topic><topic>Internal Medicine</topic><topic>Itraconazole</topic><topic>Lymph nodes</topic><topic>Male</topic><topic>Mycoses - diagnosis</topic><topic>Mycoses - drug therapy</topic><topic>Mycoses - microbiology</topic><topic>Mycoses - veterinary</topic><topic>Nucleotide sequence</topic><topic>Polymerase Chain Reaction</topic><topic>Spacer region</topic><topic>Spleen</topic><topic>systemic mycosis</topic><topic>Tachycardia</topic><topic>Tachycardia - veterinary</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FURUSAWA, Yu</creatorcontrib><creatorcontrib>TAKAHASHI, Masashi</creatorcontrib><creatorcontrib>IWANAGA, Tomoko</creatorcontrib><creatorcontrib>YABUKI, Akira</creatorcontrib><creatorcontrib>KANO, Rui</creatorcontrib><creatorcontrib>HATAI, Hitoshi</creatorcontrib><creatorcontrib>SUENO, Wako</creatorcontrib><creatorcontrib>ENDO, Yasuyuki</creatorcontrib><creatorcontrib>MOMOI, Yasuyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FURUSAWA, Yu</au><au>TAKAHASHI, Masashi</au><au>IWANAGA, Tomoko</au><au>YABUKI, Akira</au><au>KANO, Rui</au><au>HATAI, Hitoshi</au><au>SUENO, Wako</au><au>ENDO, Yasuyuki</au><au>MOMOI, Yasuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic Inonotus sp. Infection in a dog</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2020</date><risdate>2020</risdate><volume>82</volume><issue>6</issue><spage>779</spage><epage>783</epage><pages>779-783</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>A 3-years-old male golden retriever was presented for decreased activity (lethargy), anorexia, and titubation. Superficial lymph nodes were enlarged, and arrhythmia and tachycardia were auscultated. Fungal hyphae-like structures were detected in the biopsy samples from an enlarged lymph node and spleen. Nucleotide sequence of the internal transcribed spacer region of the fungi amplified by PCR was highly homologous to that of Inonotus pachyphloeus. The dog was treated with antifungal agents such as itraconazole, fluconazole, and voriconazole. Clinical signs resolved for 325 days but the dog died suddenly, possibly because of arrhythmia. Postmortem examination revealed the presence of a disseminated fungal infection. This report describes the case of canine systemic Inonotus sp. infection treated by an antifungal agent.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>32378518</pmid><doi>10.1292/jvms.19-0455</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anorexia antifungal agent Antifungal agents Antifungal Agents - therapeutic use Arrhythmia Arrhythmias, Cardiac - veterinary Biopsy Cardiac arrhythmia DNA, Fungal DNA, Ribosomal Spacer dog Dog Diseases - diagnosis Dog Diseases - drug therapy Dog Diseases - microbiology Dogs Fluconazole Fungi Hyphae Infections Inonotus - drug effects Inonotus - genetics Inonotus - isolation & purification Inonotus sp Internal Medicine Itraconazole Lymph nodes Male Mycoses - diagnosis Mycoses - drug therapy Mycoses - microbiology Mycoses - veterinary Nucleotide sequence Polymerase Chain Reaction Spacer region Spleen systemic mycosis Tachycardia Tachycardia - veterinary Voriconazole |
| title | Systemic Inonotus sp. Infection in a dog |
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