Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch

The baroreceptor reflex is a powerful neural feedback that regulates arterial pressure (AP). Mechanosensitive channels transduce pulsatile AP to electrical signals in baroreceptors. Here we show that tentonin 3 (TTN3/TMEM150C), a cation channel activated by mechanical strokes, is essential for detec...

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Veröffentlicht in:	The Journal of clinical investigation 2020-07, Vol.130 (7), p.3671-3683
Hauptverfasser:	Lu, Huan-Jun, Nguyen, Thien-Luan, Hong, Gyu-Sang, Pak, Sungmin, Kim, Hyesu, Kim, Hyungsup, Kim, Dong-Yoon, Kim, Sung-Yon, Shen, Yiming, Ryu, Pan Dong, Lee, Mi-Ock, Oh, Uhtaek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - innervation Aorta, Thoracic - metabolism Aorta, Thoracic - physiopathology Blood Pressure Diagnosis Heart rate HEK293 Cells Humans Hypertension Hypertension - genetics Hypertension - metabolism Hypertension - physiopathology Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Neurons Neurons - metabolism Nodose Ganglion - metabolism Nodose Ganglion - physiopathology Pressoreceptors - metabolism Pressoreceptors - physiopathology Scientific equipment industry Tachycardia - genetics Tachycardia - metabolism Tachycardia - physiopathology
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