Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction

Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism governing pericyte degeneration is poorly understood. Circular RNAs (circRNAs) play important roles in multiple biologi...

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Veröffentlicht in:	The Journal of clinical investigation 2020-07, Vol.130 (7), p.3833-3847
Hauptverfasser:	Jiang, Qin, Liu, Chang, Li, Chao-Peng, Xu, Shan-Shan, Yao, Mu-Di, Ge, Hui-Min, Sun, Ya-Nan, Li, Xiu-Miao, Zhang, Shu-Jie, Shan, Kun, Liu, Bai-Hui, Yao, Jin, Zhao, Chen, Yan, Biao
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Antibodies Binding sites Biology Biomedical research Blindness Blood vessels Cell cycle Cell Line Circular RNA Cyclin-dependent kinase 2 Datasets Degeneration Diabetes Diabetes mellitus Diabetic retinopathy Diabetic Retinopathy - genetics Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Endothelial cells Eye Proteins - genetics Eye Proteins - metabolism Gene expression Glucose Growth factors Homeostasis Humans Mice MicroRNAs - genetics MicroRNAs - metabolism Oxidative stress Pericytes Pericytes - metabolism Pericytes - pathology Physiological aspects Retina Retinal Vessels - metabolism Retinal Vessels - pathology Retinopathy Ribonucleic acid RNA RNA, Circular - genetics RNA, Circular - metabolism Streptozocin Variance analysis Vitreous humor
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