Novel coronavirus infection (COVID‐19) in children younger than one year: A systematic review of symptoms, management and outcomes
Aim The aim of this systematic review was to evaluate the clinical characteristics of COVID‐19 in neonates and children under one year of age. Methods A systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from January 1, 2020, to April...
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| Veröffentlicht in: | Acta Paediatrica 2020-10, Vol.109 (10), p.1948-1955 |
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| container_end_page | 1955 |
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| container_issue | 10 |
| container_start_page | 1948 |
| container_title | Acta Paediatrica |
| container_volume | 109 |
| creator | Raba, Ali Ahmed Abobaker, Anis Elgenaidi, Ismail Suliman Daoud, Ahmed |
| description | Aim
The aim of this systematic review was to evaluate the clinical characteristics of COVID‐19 in neonates and children under one year of age.
Methods
A systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from January 1, 2020, to April 7, 2020. We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates.
Results
Our search identified 77 peer‐reviewed papers, and 18 papers covering 160 infants were reviewed. One paper was from Vietnam, and the other 17 were from China: eight were cross‐sectional studies, eight were case reports, one was a case series, and one was a prospective cohort study. The most common clinical symptoms were fever (54%) and cough (33%). Most infants were treated symptomatically, with frequent use of various empirical medications. Infants and neonates tended to have more severe COVID‐19 disease than older children: 11 (7%) were admitted to intensive care and one infant died. The mortality rate was 0.006%, with favourable outcomes in most cases.
Conclusion
Infants and neonates were more vulnerable to more severe COVID‐19 disease than older children, but morbidity and mortality were low. |
| doi_str_mv | 10.1111/apa.15422 |
| format | Article |
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The aim of this systematic review was to evaluate the clinical characteristics of COVID‐19 in neonates and children under one year of age.
Methods
A systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from January 1, 2020, to April 7, 2020. We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates.
Results
Our search identified 77 peer‐reviewed papers, and 18 papers covering 160 infants were reviewed. One paper was from Vietnam, and the other 17 were from China: eight were cross‐sectional studies, eight were case reports, one was a case series, and one was a prospective cohort study. The most common clinical symptoms were fever (54%) and cough (33%). Most infants were treated symptomatically, with frequent use of various empirical medications. Infants and neonates tended to have more severe COVID‐19 disease than older children: 11 (7%) were admitted to intensive care and one infant died. The mortality rate was 0.006%, with favourable outcomes in most cases.
Conclusion
Infants and neonates were more vulnerable to more severe COVID‐19 disease than older children, but morbidity and mortality were low.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.15422</identifier><identifier>PMID: 32557789</identifier><language>eng</language><publisher>Norway: Wiley Subscription Services, Inc</publisher><subject>Case reports ; Children ; clinical characteristics ; Coronaviruses ; Cough ; COVID-19 ; COVID-19 - blood ; COVID-19 - epidemiology ; COVID-19 - therapy ; Cross-sectional studies ; Fever ; Humans ; Infant ; Infant, Newborn ; Infants ; Literature reviews ; Morbidity ; Mortality ; Neonates ; novel coronavirus ; outcomes ; Review ; Systematic review</subject><ispartof>Acta Paediatrica, 2020-10, Vol.109 (10), p.1948-1955</ispartof><rights>2020 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><rights>2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5132-8180b47eaba422cac45c37ee8443037ac2fdcea9e1609836470c7809e20bcd923</citedby><cites>FETCH-LOGICAL-c5132-8180b47eaba422cac45c37ee8443037ac2fdcea9e1609836470c7809e20bcd923</cites><orcidid>0000-0003-2133-319X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.15422$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.15422$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32557789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raba, Ali Ahmed</creatorcontrib><creatorcontrib>Abobaker, Anis</creatorcontrib><creatorcontrib>Elgenaidi, Ismail Suliman</creatorcontrib><creatorcontrib>Daoud, Ahmed</creatorcontrib><title>Novel coronavirus infection (COVID‐19) in children younger than one year: A systematic review of symptoms, management and outcomes</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim
The aim of this systematic review was to evaluate the clinical characteristics of COVID‐19 in neonates and children under one year of age.
Methods
A systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from January 1, 2020, to April 7, 2020. We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates.
Results
Our search identified 77 peer‐reviewed papers, and 18 papers covering 160 infants were reviewed. One paper was from Vietnam, and the other 17 were from China: eight were cross‐sectional studies, eight were case reports, one was a case series, and one was a prospective cohort study. The most common clinical symptoms were fever (54%) and cough (33%). Most infants were treated symptomatically, with frequent use of various empirical medications. Infants and neonates tended to have more severe COVID‐19 disease than older children: 11 (7%) were admitted to intensive care and one infant died. The mortality rate was 0.006%, with favourable outcomes in most cases.
Conclusion
Infants and neonates were more vulnerable to more severe COVID‐19 disease than older children, but morbidity and mortality were low.</description><subject>Case reports</subject><subject>Children</subject><subject>clinical characteristics</subject><subject>Coronaviruses</subject><subject>Cough</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - therapy</subject><subject>Cross-sectional studies</subject><subject>Fever</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Literature reviews</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neonates</subject><subject>novel coronavirus</subject><subject>outcomes</subject><subject>Review</subject><subject>Systematic review</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1uEzEQxy0EoiFw4AWQJS6txLb-WGd3OSBFKR-VKsoBuFoTZzZxtbZTezfV3jj0AXhGngSXlAqQmIulmZ9-ntGfkOecHfNcJ7CFY65KIR6QCZ8pXgghqodkwmomCyWUPCBPUrpkTMimnD0mB1IoVVV1MyE3H8MOO2pCDB52Ng6JWt-i6W3w9HBx8fXs9Me377w5ym1qNrZbRfR0DINfY6T9BjwNHumIEF_TOU1j6tFBbw2NuLN4TUObm27bB5deUQce1ujQ9xT8ioahN8FhekoetdAlfHb3TsmXd28_Lz4U5xfvzxbz88IoLkVR85otywphCflWA6ZURlaIdVlKJiswol0ZhAb5jDW1nJUVM1XNGhRsaVaNkFPyZu_dDkuHmfV9hE5vo3UQRx3A6r8n3m70Oux0JYWUimXB4Z0ghqsBU6-dTQa7DjyGIWlRciWausm_T8nLf9DLMESfz8tUrhxAfSs82lMmhpQitvfLcKZvs9U5W_0r28y--HP7e_J3mBk42QPXtsPx_yY9_zTfK38CM0SwAw</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Raba, Ali Ahmed</creator><creator>Abobaker, Anis</creator><creator>Elgenaidi, Ismail Suliman</creator><creator>Daoud, Ahmed</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2133-319X</orcidid></search><sort><creationdate>202010</creationdate><title>Novel coronavirus infection (COVID‐19) in children younger than one year: A systematic review of symptoms, management and outcomes</title><author>Raba, Ali Ahmed ; Abobaker, Anis ; Elgenaidi, Ismail Suliman ; Daoud, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5132-8180b47eaba422cac45c37ee8443037ac2fdcea9e1609836470c7809e20bcd923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Case reports</topic><topic>Children</topic><topic>clinical characteristics</topic><topic>Coronaviruses</topic><topic>Cough</topic><topic>COVID-19</topic><topic>COVID-19 - blood</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - therapy</topic><topic>Cross-sectional studies</topic><topic>Fever</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Literature reviews</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Neonates</topic><topic>novel coronavirus</topic><topic>outcomes</topic><topic>Review</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raba, Ali Ahmed</creatorcontrib><creatorcontrib>Abobaker, Anis</creatorcontrib><creatorcontrib>Elgenaidi, Ismail Suliman</creatorcontrib><creatorcontrib>Daoud, Ahmed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raba, Ali Ahmed</au><au>Abobaker, Anis</au><au>Elgenaidi, Ismail Suliman</au><au>Daoud, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel coronavirus infection (COVID‐19) in children younger than one year: A systematic review of symptoms, management and outcomes</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2020-10</date><risdate>2020</risdate><volume>109</volume><issue>10</issue><spage>1948</spage><epage>1955</epage><pages>1948-1955</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim
The aim of this systematic review was to evaluate the clinical characteristics of COVID‐19 in neonates and children under one year of age.
Methods
A systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from January 1, 2020, to April 7, 2020. We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates.
Results
Our search identified 77 peer‐reviewed papers, and 18 papers covering 160 infants were reviewed. One paper was from Vietnam, and the other 17 were from China: eight were cross‐sectional studies, eight were case reports, one was a case series, and one was a prospective cohort study. The most common clinical symptoms were fever (54%) and cough (33%). Most infants were treated symptomatically, with frequent use of various empirical medications. Infants and neonates tended to have more severe COVID‐19 disease than older children: 11 (7%) were admitted to intensive care and one infant died. The mortality rate was 0.006%, with favourable outcomes in most cases.
Conclusion
Infants and neonates were more vulnerable to more severe COVID‐19 disease than older children, but morbidity and mortality were low.</abstract><cop>Norway</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32557789</pmid><doi>10.1111/apa.15422</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2133-319X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta Paediatrica, 2020-10, Vol.109 (10), p.1948-1955 |
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| language | eng |
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| source | MEDLINE; Wiley Journals; Alma/SFX Local Collection |
| subjects | Case reports Children clinical characteristics Coronaviruses Cough COVID-19 COVID-19 - blood COVID-19 - epidemiology COVID-19 - therapy Cross-sectional studies Fever Humans Infant Infant, Newborn Infants Literature reviews Morbidity Mortality Neonates novel coronavirus outcomes Review Systematic review |
| title | Novel coronavirus infection (COVID‐19) in children younger than one year: A systematic review of symptoms, management and outcomes |
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