SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases

Summary Background Chilblains (‘COVID toes’) are being seen with increasing frequency in children and young adults during the COVID‐19 pandemic. Detailed histopathological descriptions of COVID‐19 chilblains have not been reported, and causality of SARS‐CoV‐2 has not yet been established. Objectives...

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Veröffentlicht in:	British journal of dermatology (1951) 2020-10, Vol.183 (4), p.729-737
Hauptverfasser:	Colmenero, I., Santonja, C., Alonso‐Riaño, M., Noguera‐Morel, L., Hernández‐Martín, A., Andina, D., Wiesner, T., Rodríguez‐Peralto, J.L., Requena, L., Torrelo, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Betacoronavirus - isolation & purification Betacoronavirus - pathogenicity Biopsy Chilblains - pathology Chilblains - virology Child Coronavirus Infections - complications Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 Cytoplasm Edema Electron microscopy Endothelial cells Endothelial Cells - pathology Endothelial Cells - ultrastructure Endothelial Cells - virology Endothelium Endothelium, Vascular - pathology Endothelium, Vascular - virology Epithelial cells Glands Histopathology Humans Immunohistochemistry Interferon Ischemia Microscopy Microscopy, Electron Original Paediatric Dermatology Pandemics Pediatrics Pneumonia, Viral - complications Pneumonia, Viral - pathology Pneumonia, Viral - virology Purpura SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Skin - blood supply Skin - pathology Skin - virology Skin Diseases - pathology Skin Diseases - virology Thrombosis Vasculitis Vasculitis - pathology Vasculitis - virology Young adults
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