Line-selective macrophage activation with an anti-CD40 antibody drives a hemophagocytic syndrome in mice

Hemophagocytic syndromes comprise a cluster of hyperinflammatory disorders, including hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Overwhelming macrophage activation has long been considered a final common pathway in the pathophysiology of hemophagocytic syndromes leading t...

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Veröffentlicht in:	Blood advances 2020-06, Vol.4 (12), p.2751-2761
Hauptverfasser:	Ingoglia, Giada, Yalamanoglu, Ayla, Pfefferlé, Marc, Dubach, Irina L., Schaer, Christian A., Valkova, Kristyna, Hansen, Kerstin, Schulthess, Nadja, Humar, Rok, Schaer, Dominik J., Vallelian, Florence
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Interferon-gamma Lymphohistiocytosis, Hemophagocytic Macrophage Activation Macrophage Activation Syndrome Macrophages Mice Phagocytes, Granulocytes, and Myelopoiesis
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