Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

Alzheimer's disease and its complications are the leading cause of death in adults with Down syndrome. Studies have assessed Alzheimer's disease in individuals with Down syndrome, but the natural history of biomarker changes in Down syndrome has not been established. We characterised the o...

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Veröffentlicht in:	The Lancet (British edition) 2020-06, Vol.395 (10242), p.1988-1997
Hauptverfasser:	Fortea, Juan, Vilaplana, Eduard, Carmona-Iragui, Maria, Benejam, Bessy, Videla, Laura, Barroeta, Isabel, Fernández, Susana, Altuna, Miren, Pegueroles, Jordi, Montal, Víctor, Valldeneu, Silvia, Giménez, Sandra, González-Ortiz, Sofía, Muñoz, Laia, Estellés, Teresa, Illán-Gala, Ignacio, Belbin, Olivia, Camacho, Valle, Wilson, Liam Reese, Annus, Tiina, Osorio, Ricardo S, Videla, Sebastián, Lehmann, Sylvain, Holland, Anthony J, Alcolea, Daniel, Clarimón, Jordi, Zaman, Shahid H, Blesa, Rafael, Lleó, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adult Adults Age Alzheimer Disease Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnostic imaging Alzheimer Disease - epidemiology Alzheimer Disease - metabolism Alzheimer's disease Amyloid Amyloid beta-Peptides Amyloid beta-Peptides - metabolism Amyloidosis Amyloidosis - diagnostic imaging Amyloidosis - pathology Apolipoprotein E Apolipoproteins E Apolipoproteins E - metabolism Atrophy Automation Biomarkers Biomarkers - blood Caregivers Carrier density Case-Control Studies Cerebrospinal fluid Cognition Cognitive ability Cognitive Dysfunction Cognitive Dysfunction - psychology Cross-Sectional Studies Dementia Dementia disorders Down Syndrome Down Syndrome - complications Down Syndrome - epidemiology Down Syndrome - mortality Down Syndrome - psychology Down's syndrome Fluorine isotopes Fluorodeoxyglucose F18 Fluorodeoxyglucose F18 - administration & dosage Hippocampus Hospitals Human health and pathology Humans Intellectual disabilities Life Sciences Magnetic Resonance Imaging Magnetic Resonance Imaging - methods Medical imaging Medical research Mental disorders Metabolism Middle Aged Natural history Neurobiology Neurodegeneration Neurodegenerative diseases Neurofilament Proteins Neurofilament Proteins - cerebrospinal fluid Neurons and Cognition Older people Peptides Plasma Population Positron emission Positron emission tomography Positron-Emission Tomography - methods Prevalence Proteins Psychiatrics and mental health Spain Spain - epidemiology Tau protein tau Proteins tau Proteins - metabolism Threonine Tomography Tracers United Kingdom United Kingdom - epidemiology
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