H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction

Nearly 50% of mouse and human genomes are composed of repetitive sequences. Transcription of these sequences is tightly controlled during development to prevent genomic instability, inappropriate gene activation and other maladaptive processes. Here, we demonstrate an integral role for H1 linker his...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-06, Vol.117 (25), p.14251-14258
Hauptverfasser:	Healton, Sean E., Pinto, Hugo D., Mishra, Laxmi N., Hamilton, Gregory A., Wheat, Justin C., Swist-Rosowska, Kalina, Shukeir, Nicholas, Dou, Yali, Steidl, Ulrich, Jenuwein, Thomas, Gamble, Matthew J., Skoultchi, Arthur I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Chromatin Chromatin - metabolism Compaction Control stability Depletion DNA methylation Embryo cells Epigenomics Genomes Genomic instability Heterochromatin Heterochromatin - metabolism Histone-Lysine N-Methyltransferase - metabolism Histones Histones - metabolism Methylation Methyltransferases - metabolism Mice Mouse Embryonic Stem Cells - metabolism Repetitive Sequences, Nucleic Acid - physiology Repressor Proteins - metabolism Stem cell transplantation Stem cells Transcription activation
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