Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin

A eukaryotic chromosome relies on the function of multiple spatially distributed DNA replication origins for its stable inheritance. The spatial location of an origin is determined by the chromosomal position of an MCM complex, the inactive form of the DNA replicative helicase that is assembled onto...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-06, Vol.117 (25), p.14314-14321
Hauptverfasser:	Hoggard, Timothy, Müller, Carolin A., Nieduszynski, Conrad A., Weinreich, Michael, Fox, Catherine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Attenuation Biological Sciences Cell Cycle Proteins - metabolism Chromosomal Proteins, Non-Histone Chromosomes Deoxyribonucleic acid DNA DNA biosynthesis DNA helicase DNA Helicases DNA Replication Euchromatin Euchromatin - metabolism Genomes Heredity Heterochromatin Histone deacetylase Licenses Licensing Normal distribution Origins Replicating Replication Replication Origin - genetics Replication origins Reproduction (copying) Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 2 - metabolism Spatial distribution Yeasts
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