cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

Because raising cAMP enhances 26S proteasome activity and the degradation of cell proteins, including the selective breakdown of misfolded proteins, we investigated whether agents that raise cGMP may also regulate protein degradation. Treating various cell lines with inhibitors of phosphodiesterase...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-06, Vol.117 (25), p.14220-14230
Hauptverfasser:	VerPlank, Jordan J. S., Tyrkalska, Sylwia D., Fleming, Angeleen, Rubinsztein, David C., Goldberg, Alfred L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animals Animals, Genetically Modified Biodegradation Biological Sciences Cell death Cell lines Conjugation Cyclic AMP Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic GMP Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - metabolism Degradation Disease Models, Animal Guanylate cyclase Humans Huntingtin Huntington's disease Huntingtons disease Kinases Mutants Neurodegenerative diseases Neurodegenerative Diseases - metabolism Phosphodiesterase Phosphorylation Proteasome 26S Proteasome Endopeptidase Complex - metabolism Proteasomes Protein folding Protein kinase A Protein kinase G Proteins Proteolysis Stimulators Tau protein tau Proteins - metabolism Tauopathies Ubiquitin Ubiquitin - metabolism Ubiquitinated Proteins - metabolism Ubiquitination Zebrafish
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