Pulsed Laser Deposition Derived Bioactive Glass-Ceramic Coatings for Enhancing the Biocompatibility of Scaffolding Materials
The purpose of this work was to propose and evaluate a new composition for a bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological r...
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creator | Schitea, Ruxandra-Ioana Nitu, Alexandru Ciobota, Andreea-Aurelia Munteanu, Andrei-Lucian David, Irina-Madalina Miu, Dana Raileanu, Mina Bacalum, Mihaela Busuioc, Cristina |
description | The purpose of this work was to propose and evaluate a new composition for a bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological response. This had the following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% MgO, and 24.4% Na2O. The precursor alkoxides and nitrates were processed by a standard sol-gel technique, resulting in a glass-ceramic target, suitable for laser ablation experiments. Combeite (Na2Ca2Si3O9) was identified as a main crystalline phase within the calcined sol-gel powder, as well as in the case of the target sintered at 900 °C. The thin films were deposited on silicon substrates, at room temperature or 300 °C, being subsequently characterized from the material point of view, as well as in terms of bioactivity in simulated conditions and biocompatibility in relation to human fibroblast BJ cells. The investigations revealed the deposition of nanostructured glassy layers with a low proportion of crystalline domains; it was shown that a higher substrate temperature promoted the formation of surfaces with less irregularities, as a consequence of material arrangement into a shell with better morphological homogeneity. The complex elemental composition of the target was successfully transferred to the coatings, which ensured pronounced mineralization and a stimulating environment for the cell cultures. Thereby, both samples were covered with a thick layer of apatite after immersion in simulated body fluid for 28 days, and the one processed at room temperature was qualified to be the best in relation to the cells. |
doi_str_mv | 10.3390/ma13112615 |
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Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological response. This had the following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% MgO, and 24.4% Na2O. The precursor alkoxides and nitrates were processed by a standard sol-gel technique, resulting in a glass-ceramic target, suitable for laser ablation experiments. Combeite (Na2Ca2Si3O9) was identified as a main crystalline phase within the calcined sol-gel powder, as well as in the case of the target sintered at 900 °C. The thin films were deposited on silicon substrates, at room temperature or 300 °C, being subsequently characterized from the material point of view, as well as in terms of bioactivity in simulated conditions and biocompatibility in relation to human fibroblast BJ cells. The investigations revealed the deposition of nanostructured glassy layers with a low proportion of crystalline domains; it was shown that a higher substrate temperature promoted the formation of surfaces with less irregularities, as a consequence of material arrangement into a shell with better morphological homogeneity. The complex elemental composition of the target was successfully transferred to the coatings, which ensured pronounced mineralization and a stimulating environment for the cell cultures. Thereby, both samples were covered with a thick layer of apatite after immersion in simulated body fluid for 28 days, and the one processed at room temperature was qualified to be the best in relation to the cells.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma13112615</identifier><identifier>PMID: 32521699</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Ablation ; Alkoxides ; Apatite ; Biocompatibility ; Bioglass ; Biological activity ; Biological properties ; Biomedical materials ; Body fluids ; Ceramic coatings ; Composition ; Crystal structure ; Crystallinity ; Glass ceramics ; Homogeneity ; Hydroxyapatite ; In vitro methods and tests ; Laser ablation ; Lasers ; Magnesium oxide ; Mechanical properties ; Medical research ; Nitrates ; Phosphorus pentoxide ; Pulsed laser deposition ; Pulsed lasers ; Room temperature ; Silicon dioxide ; Submerging ; Thin films ; Tissue engineering</subject><ispartof>Materials, 2020-06, Vol.13 (11), p.2615</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-9b5a16d5834ba6f239b4b54b77859c32b365fbb5ecb963841d325bb3ee9dca933</citedby><cites>FETCH-LOGICAL-c383t-9b5a16d5834ba6f239b4b54b77859c32b365fbb5ecb963841d325bb3ee9dca933</cites><orcidid>0000-0002-7309-6002 ; 0000-0002-0392-8459</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321570/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321570/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Schitea, Ruxandra-Ioana</creatorcontrib><creatorcontrib>Nitu, Alexandru</creatorcontrib><creatorcontrib>Ciobota, Andreea-Aurelia</creatorcontrib><creatorcontrib>Munteanu, Andrei-Lucian</creatorcontrib><creatorcontrib>David, Irina-Madalina</creatorcontrib><creatorcontrib>Miu, Dana</creatorcontrib><creatorcontrib>Raileanu, Mina</creatorcontrib><creatorcontrib>Bacalum, Mihaela</creatorcontrib><creatorcontrib>Busuioc, Cristina</creatorcontrib><title>Pulsed Laser Deposition Derived Bioactive Glass-Ceramic Coatings for Enhancing the Biocompatibility of Scaffolding Materials</title><title>Materials</title><description>The purpose of this work was to propose and evaluate a new composition for a bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological response. This had the following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% MgO, and 24.4% Na2O. The precursor alkoxides and nitrates were processed by a standard sol-gel technique, resulting in a glass-ceramic target, suitable for laser ablation experiments. Combeite (Na2Ca2Si3O9) was identified as a main crystalline phase within the calcined sol-gel powder, as well as in the case of the target sintered at 900 °C. The thin films were deposited on silicon substrates, at room temperature or 300 °C, being subsequently characterized from the material point of view, as well as in terms of bioactivity in simulated conditions and biocompatibility in relation to human fibroblast BJ cells. The investigations revealed the deposition of nanostructured glassy layers with a low proportion of crystalline domains; it was shown that a higher substrate temperature promoted the formation of surfaces with less irregularities, as a consequence of material arrangement into a shell with better morphological homogeneity. The complex elemental composition of the target was successfully transferred to the coatings, which ensured pronounced mineralization and a stimulating environment for the cell cultures. Thereby, both samples were covered with a thick layer of apatite after immersion in simulated body fluid for 28 days, and the one processed at room temperature was qualified to be the best in relation to the cells.</description><subject>Ablation</subject><subject>Alkoxides</subject><subject>Apatite</subject><subject>Biocompatibility</subject><subject>Bioglass</subject><subject>Biological activity</subject><subject>Biological properties</subject><subject>Biomedical materials</subject><subject>Body fluids</subject><subject>Ceramic coatings</subject><subject>Composition</subject><subject>Crystal structure</subject><subject>Crystallinity</subject><subject>Glass ceramics</subject><subject>Homogeneity</subject><subject>Hydroxyapatite</subject><subject>In vitro methods and tests</subject><subject>Laser ablation</subject><subject>Lasers</subject><subject>Magnesium oxide</subject><subject>Mechanical properties</subject><subject>Medical research</subject><subject>Nitrates</subject><subject>Phosphorus pentoxide</subject><subject>Pulsed laser deposition</subject><subject>Pulsed lasers</subject><subject>Room temperature</subject><subject>Silicon dioxide</subject><subject>Submerging</subject><subject>Thin films</subject><subject>Tissue engineering</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkdFLHDEQxkNRqpy-9C8I9KUIq5vMZm_zIuipV-HEQtvnMMlmvcju5kyywkH_-Oaq2Na8zDd8v3zMMIR8YuUpgCzPBmTAGK-Z-EAOmZR1wWRV7f2jD8hxjI9lfgCs4fIjOQAuOKulPCS_vk19tC1dYbSBXtmNjy45P2YZ3HM2Lp1Hk7Kkyx5jLBY24OAMXXhMbnyItPOBXo9rHE1uaVrb3Rfjh032tetd2lLf0e8Gu8737Y65w5TDsY9HZL_LxR6_1hn5eXP9Y_G1WN0vbxcXq8JAA6mQWiCrW9FApbHuOEhdaVHp-bwR0gDXUItOa2GNljU0FWvzflqDtbI1KAFm5PwldzPpwbbGjilgrzbBDRi2yqNT_zujW6sH_6zmwJmYlzngy2tA8E-TjUkNLhrb9zhaP0XFK8Y5Y00ecUY-v0Mf_RTGvN4fqha8kTJTJy-UCT7GYLu3YVipdndVf-8KvwHKMZWI</recordid><startdate>20200608</startdate><enddate>20200608</enddate><creator>Schitea, Ruxandra-Ioana</creator><creator>Nitu, Alexandru</creator><creator>Ciobota, Andreea-Aurelia</creator><creator>Munteanu, Andrei-Lucian</creator><creator>David, Irina-Madalina</creator><creator>Miu, Dana</creator><creator>Raileanu, Mina</creator><creator>Bacalum, Mihaela</creator><creator>Busuioc, Cristina</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7309-6002</orcidid><orcidid>https://orcid.org/0000-0002-0392-8459</orcidid></search><sort><creationdate>20200608</creationdate><title>Pulsed Laser Deposition Derived Bioactive Glass-Ceramic Coatings for Enhancing the Biocompatibility of Scaffolding Materials</title><author>Schitea, Ruxandra-Ioana ; 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Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological response. This had the following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% MgO, and 24.4% Na2O. The precursor alkoxides and nitrates were processed by a standard sol-gel technique, resulting in a glass-ceramic target, suitable for laser ablation experiments. Combeite (Na2Ca2Si3O9) was identified as a main crystalline phase within the calcined sol-gel powder, as well as in the case of the target sintered at 900 °C. The thin films were deposited on silicon substrates, at room temperature or 300 °C, being subsequently characterized from the material point of view, as well as in terms of bioactivity in simulated conditions and biocompatibility in relation to human fibroblast BJ cells. The investigations revealed the deposition of nanostructured glassy layers with a low proportion of crystalline domains; it was shown that a higher substrate temperature promoted the formation of surfaces with less irregularities, as a consequence of material arrangement into a shell with better morphological homogeneity. The complex elemental composition of the target was successfully transferred to the coatings, which ensured pronounced mineralization and a stimulating environment for the cell cultures. Thereby, both samples were covered with a thick layer of apatite after immersion in simulated body fluid for 28 days, and the one processed at room temperature was qualified to be the best in relation to the cells.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>32521699</pmid><doi>10.3390/ma13112615</doi><orcidid>https://orcid.org/0000-0002-7309-6002</orcidid><orcidid>https://orcid.org/0000-0002-0392-8459</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Ablation Alkoxides Apatite Biocompatibility Bioglass Biological activity Biological properties Biomedical materials Body fluids Ceramic coatings Composition Crystal structure Crystallinity Glass ceramics Homogeneity Hydroxyapatite In vitro methods and tests Laser ablation Lasers Magnesium oxide Mechanical properties Medical research Nitrates Phosphorus pentoxide Pulsed laser deposition Pulsed lasers Room temperature Silicon dioxide Submerging Thin films Tissue engineering |
title | Pulsed Laser Deposition Derived Bioactive Glass-Ceramic Coatings for Enhancing the Biocompatibility of Scaffolding Materials |
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