Pulsed Laser Deposition Derived Bioactive Glass-Ceramic Coatings for Enhancing the Biocompatibility of Scaffolding Materials

The purpose of this work was to propose and evaluate a new composition for a bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological r...

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Veröffentlicht in:Materials 2020-06, Vol.13 (11), p.2615
Hauptverfasser: Schitea, Ruxandra-Ioana, Nitu, Alexandru, Ciobota, Andreea-Aurelia, Munteanu, Andrei-Lucian, David, Irina-Madalina, Miu, Dana, Raileanu, Mina, Bacalum, Mihaela, Busuioc, Cristina
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creator Schitea, Ruxandra-Ioana
Nitu, Alexandru
Ciobota, Andreea-Aurelia
Munteanu, Andrei-Lucian
David, Irina-Madalina
Miu, Dana
Raileanu, Mina
Bacalum, Mihaela
Busuioc, Cristina
description The purpose of this work was to propose and evaluate a new composition for a bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed a modified version, including MgO, an oxide that turned out to induce superior mechanical properties and improved biological response. This had the following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% MgO, and 24.4% Na2O. The precursor alkoxides and nitrates were processed by a standard sol-gel technique, resulting in a glass-ceramic target, suitable for laser ablation experiments. Combeite (Na2Ca2Si3O9) was identified as a main crystalline phase within the calcined sol-gel powder, as well as in the case of the target sintered at 900 °C. The thin films were deposited on silicon substrates, at room temperature or 300 °C, being subsequently characterized from the material point of view, as well as in terms of bioactivity in simulated conditions and biocompatibility in relation to human fibroblast BJ cells. The investigations revealed the deposition of nanostructured glassy layers with a low proportion of crystalline domains; it was shown that a higher substrate temperature promoted the formation of surfaces with less irregularities, as a consequence of material arrangement into a shell with better morphological homogeneity. The complex elemental composition of the target was successfully transferred to the coatings, which ensured pronounced mineralization and a stimulating environment for the cell cultures. Thereby, both samples were covered with a thick layer of apatite after immersion in simulated body fluid for 28 days, and the one processed at room temperature was qualified to be the best in relation to the cells.
doi_str_mv 10.3390/ma13112615
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source PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry
subjects Ablation
Alkoxides
Apatite
Biocompatibility
Bioglass
Biological activity
Biological properties
Biomedical materials
Body fluids
Ceramic coatings
Composition
Crystal structure
Crystallinity
Glass ceramics
Homogeneity
Hydroxyapatite
In vitro methods and tests
Laser ablation
Lasers
Magnesium oxide
Mechanical properties
Medical research
Nitrates
Phosphorus pentoxide
Pulsed laser deposition
Pulsed lasers
Room temperature
Silicon dioxide
Submerging
Thin films
Tissue engineering
title Pulsed Laser Deposition Derived Bioactive Glass-Ceramic Coatings for Enhancing the Biocompatibility of Scaffolding Materials
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