In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model
The hollow cylindrical nanohydroxyapatite/polyamide 66 strut (n-HA/PA66) has been used clinically for anterior cervical reconstruction. However, rates of occurrence of a “radiolucent gap” between the dense strut and adjacent endplates were reported. The aim of this in vivo study was to evaluate the...
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| Veröffentlicht in: | Scientific reports 2020-06, Vol.10 (1), p.10495, Article 10495 |
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| description | The hollow cylindrical nanohydroxyapatite/polyamide 66 strut (n-HA/PA66) has been used clinically for anterior cervical reconstruction. However, rates of occurrence of a “radiolucent gap” between the dense strut and adjacent endplates were reported. The aim of this
in vivo
study was to evaluate the viability and advantages of the novel porous n-HA/PA66 strut. The goat C3/4 partial discectomy and fusion model was built, and two groups of n-HA/PA66 struts were implanted into C3/4: group 1, porous n-HA/PA66 strut; and group 2, hollow cylindrical n-HA/PA66 strut filled with autogenous cancellous bone. CT evaluation was performed to assess the fusion status after 12 and 24 weeks. The cervical spines were harvested. Histomorphological analysis was performed to determine new bone formation. Biomechanical testing was performed to determine range of motion (ROM). CT confirmed the disappearance of the boundary of the porous strut and host bone, while the radiolucent gap remained clearly discernible in the dense strut group. The mean CT fusion scores of the porous group were significantly higher. Histologic evaluation showed that the porous struts promoted better osteointegration. Calcein fluorochrome labelling indicated faster bone ingrowth in the porous struts. Biomechanical tests revealed that the porous struts had significantly reduced micromotion. The porous n-HA/PA66 strut could offer interesting potential for cervical reconstruction after corpectomy. |
| doi_str_mv | 10.1038/s41598-020-65341-1 |
| format | Article |
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in vivo
study was to evaluate the viability and advantages of the novel porous n-HA/PA66 strut. The goat C3/4 partial discectomy and fusion model was built, and two groups of n-HA/PA66 struts were implanted into C3/4: group 1, porous n-HA/PA66 strut; and group 2, hollow cylindrical n-HA/PA66 strut filled with autogenous cancellous bone. CT evaluation was performed to assess the fusion status after 12 and 24 weeks. The cervical spines were harvested. Histomorphological analysis was performed to determine new bone formation. Biomechanical testing was performed to determine range of motion (ROM). CT confirmed the disappearance of the boundary of the porous strut and host bone, while the radiolucent gap remained clearly discernible in the dense strut group. The mean CT fusion scores of the porous group were significantly higher. Histologic evaluation showed that the porous struts promoted better osteointegration. Calcein fluorochrome labelling indicated faster bone ingrowth in the porous struts. Biomechanical tests revealed that the porous struts had significantly reduced micromotion. The porous n-HA/PA66 strut could offer interesting potential for cervical reconstruction after corpectomy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-65341-1</identifier><identifier>PMID: 32591524</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 59/36 ; 59/57 ; 631/535/1258 ; 639/301/54/989 ; Animals ; Biomechanics ; Bone and Bones - drug effects ; Bone and Bones - surgery ; Bone growth ; Calcein ; Cancellous bone ; Cervical Vertebrae - drug effects ; Cervical Vertebrae - surgery ; Diskectomy - methods ; Durapatite - pharmacology ; Female ; Goats ; Humanities and Social Sciences ; Labeling ; multidisciplinary ; Nanoparticles - administration & dosage ; Nylons - pharmacology ; Osseointegration ; Osteogenesis ; Osteogenesis - drug effects ; Polyamides ; Porosity ; Prostheses and Implants ; Science ; Science (multidisciplinary) ; Spinal Diseases - surgery ; Spinal Fusion - methods</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.10495, Article 10495</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9581358245ebfdd220bedbb1dbd8f40d13bb1ffc86d11f12897a47506edca9013</citedby><cites>FETCH-LOGICAL-c474t-9581358245ebfdd220bedbb1dbd8f40d13bb1ffc86d11f12897a47506edca9013</cites><orcidid>0000-0002-3511-6594</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320142/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320142/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32591524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Xi</creatorcontrib><creatorcontrib>Li, Feilong</creatorcontrib><creatorcontrib>Gong, Xuan</creatorcontrib><creatorcontrib>Li, Junchao</creatorcontrib><creatorcontrib>Yin, Shijie</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Liu, Ziming</creatorcontrib><creatorcontrib>Zhao, Zenghui</creatorcontrib><creatorcontrib>Tu, Xiaolin</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><creatorcontrib>Hu, Ning</creatorcontrib><title>In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The hollow cylindrical nanohydroxyapatite/polyamide 66 strut (n-HA/PA66) has been used clinically for anterior cervical reconstruction. However, rates of occurrence of a “radiolucent gap” between the dense strut and adjacent endplates were reported. The aim of this
in vivo
study was to evaluate the viability and advantages of the novel porous n-HA/PA66 strut. The goat C3/4 partial discectomy and fusion model was built, and two groups of n-HA/PA66 struts were implanted into C3/4: group 1, porous n-HA/PA66 strut; and group 2, hollow cylindrical n-HA/PA66 strut filled with autogenous cancellous bone. CT evaluation was performed to assess the fusion status after 12 and 24 weeks. The cervical spines were harvested. Histomorphological analysis was performed to determine new bone formation. Biomechanical testing was performed to determine range of motion (ROM). CT confirmed the disappearance of the boundary of the porous strut and host bone, while the radiolucent gap remained clearly discernible in the dense strut group. The mean CT fusion scores of the porous group were significantly higher. Histologic evaluation showed that the porous struts promoted better osteointegration. Calcein fluorochrome labelling indicated faster bone ingrowth in the porous struts. Biomechanical tests revealed that the porous struts had significantly reduced micromotion. The porous n-HA/PA66 strut could offer interesting potential for cervical reconstruction after corpectomy.</description><subject>13/51</subject><subject>59/36</subject><subject>59/57</subject><subject>631/535/1258</subject><subject>639/301/54/989</subject><subject>Animals</subject><subject>Biomechanics</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - surgery</subject><subject>Bone growth</subject><subject>Calcein</subject><subject>Cancellous bone</subject><subject>Cervical Vertebrae - drug effects</subject><subject>Cervical Vertebrae - surgery</subject><subject>Diskectomy - methods</subject><subject>Durapatite - pharmacology</subject><subject>Female</subject><subject>Goats</subject><subject>Humanities and Social Sciences</subject><subject>Labeling</subject><subject>multidisciplinary</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nylons - pharmacology</subject><subject>Osseointegration</subject><subject>Osteogenesis</subject><subject>Osteogenesis - drug effects</subject><subject>Polyamides</subject><subject>Porosity</subject><subject>Prostheses and Implants</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Spinal Diseases - surgery</subject><subject>Spinal Fusion - methods</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kV1r2zAYhcVoWUOaP7CLIei1V736sK2bQgndFgj0ZrsWsiWlLo7kSrZZ_v2Upuuym-lGH-foeQ8chD4B-QKE1beJg5B1QSgpSsE4FPABLSjhoqCM0ouz8xVapfRM8hJUcpAf0RWjQoKgfIHajcdzNwdsZ91PeuyCx8HhIcQwJey1D08HE8Ovgx6yONrbIfQHve-MxWWJ0xinMeHOY413QY-4tXHuWt1jN6Ujah-M7a_RpdN9squ3fYl-fn34sf5ebB-_bdb326LlFR8LKWpgoqZc2MYZQylprGkaMI2pHScGWL4419alAXBAa1lpXglSWtNqSYAt0d2JO0zNPj9aP0bdqyF2ex0PKuhO_av47kntwqwqRglwmgE3b4AYXiabRvUcpuhzZkU5VKWUsjq66MnVxpBStO59AhB17EadulG5G_XajTpm-3ye7f3LnyaygZ0MKUt-Z-Pf2f_B_gYdZJxV</recordid><startdate>20200626</startdate><enddate>20200626</enddate><creator>Liang, Xi</creator><creator>Li, Feilong</creator><creator>Gong, Xuan</creator><creator>Li, Junchao</creator><creator>Yin, Shijie</creator><creator>Li, Qi</creator><creator>Liu, Ziming</creator><creator>Zhao, Zenghui</creator><creator>Tu, Xiaolin</creator><creator>Huang, Wei</creator><creator>Hu, Ning</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3511-6594</orcidid></search><sort><creationdate>20200626</creationdate><title>In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model</title><author>Liang, Xi ; Li, Feilong ; Gong, Xuan ; Li, Junchao ; Yin, Shijie ; Li, Qi ; Liu, Ziming ; Zhao, Zenghui ; Tu, Xiaolin ; Huang, Wei ; Hu, Ning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9581358245ebfdd220bedbb1dbd8f40d13bb1ffc86d11f12897a47506edca9013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>13/51</topic><topic>59/36</topic><topic>59/57</topic><topic>631/535/1258</topic><topic>639/301/54/989</topic><topic>Animals</topic><topic>Biomechanics</topic><topic>Bone and Bones - 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However, rates of occurrence of a “radiolucent gap” between the dense strut and adjacent endplates were reported. The aim of this
in vivo
study was to evaluate the viability and advantages of the novel porous n-HA/PA66 strut. The goat C3/4 partial discectomy and fusion model was built, and two groups of n-HA/PA66 struts were implanted into C3/4: group 1, porous n-HA/PA66 strut; and group 2, hollow cylindrical n-HA/PA66 strut filled with autogenous cancellous bone. CT evaluation was performed to assess the fusion status after 12 and 24 weeks. The cervical spines were harvested. Histomorphological analysis was performed to determine new bone formation. Biomechanical testing was performed to determine range of motion (ROM). CT confirmed the disappearance of the boundary of the porous strut and host bone, while the radiolucent gap remained clearly discernible in the dense strut group. The mean CT fusion scores of the porous group were significantly higher. Histologic evaluation showed that the porous struts promoted better osteointegration. Calcein fluorochrome labelling indicated faster bone ingrowth in the porous struts. Biomechanical tests revealed that the porous struts had significantly reduced micromotion. The porous n-HA/PA66 strut could offer interesting potential for cervical reconstruction after corpectomy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32591524</pmid><doi>10.1038/s41598-020-65341-1</doi><orcidid>https://orcid.org/0000-0002-3511-6594</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 13/51 59/36 59/57 631/535/1258 639/301/54/989 Animals Biomechanics Bone and Bones - drug effects Bone and Bones - surgery Bone growth Calcein Cancellous bone Cervical Vertebrae - drug effects Cervical Vertebrae - surgery Diskectomy - methods Durapatite - pharmacology Female Goats Humanities and Social Sciences Labeling multidisciplinary Nanoparticles - administration & dosage Nylons - pharmacology Osseointegration Osteogenesis Osteogenesis - drug effects Polyamides Porosity Prostheses and Implants Science Science (multidisciplinary) Spinal Diseases - surgery Spinal Fusion - methods |
| title | In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model |
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