Genetic risk and atrial fibrillation in patients with heart failure
Aims To study the association between an atrial fibrillation (AF) genetic risk score with prevalent AF and all‐cause mortality in patients with heart failure. Methods and results An AF genetic risk score was calculated in 3759 European ancestry individuals (1783 with sinus rhythm, 1976 with AF) from...
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| Veröffentlicht in: | European journal of heart failure 2020-03, Vol.22 (3), p.519-527 |
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| creator | Kloosterman, Mariëlle Santema, Bernadet T. Roselli, Carolina Nelson, Christopher P. Koekemoer, Andrea Romaine, Simon. P.R. Van Gelder, Isabelle C. Lam, Carolyn S.P. Artola, Vicente A. Lang, Chim C. Ng, Leon L. Metra, Marco Anker, Stefan Filippatos, Gerasimos Dickstein, Kenneth Ponikowski, Piotr Harst, Pim Meer, Peter Veldhuisen, Dirk J. Benjamin, Emelia J. Voors, Adriaan A. Samani, Nilesh J. Rienstra, Michiel |
| description | Aims
To study the association between an atrial fibrillation (AF) genetic risk score with prevalent AF and all‐cause mortality in patients with heart failure.
Methods and results
An AF genetic risk score was calculated in 3759 European ancestry individuals (1783 with sinus rhythm, 1976 with AF) from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) by summing 97 single nucleotide polymorphism (SNP) alleles (ranging from 0–2) weighted by the natural logarithm of the relative SNP risk from the latest AF genome‐wide association study. Further, we assessed AF risk variance explained by additive SNP variation, and performance of clinical or genetic risk factors, and the combination in classifying AF prevalence. AF was classified as AF or atrial flutter (AFL) at baseline electrocardiogram and/or a history of AF or AFL. The genetic risk score was associated with AF after multivariable adjustment. Odds ratio for AF prevalence per 1‐unit increase genetic risk score was 2.12 (95% confidence interval 1.84–2.45, P = 2.15 × 10−24) in the total cohort, 2.08 (1.72–2.50, P = 1.30 × 10−14) in heart failure with reduced ejection fraction (HFrEF) and 2.02 (1.37–2.99, P = 4.37 × 10−4) in heart failure with preserved ejection fraction (HFpEF). AF‐associated loci explained 22.9% of overall AF SNP heritability. Addition of the genetic risk score to clinical risk factors increased the C‐index by 2.2% to 0.721.
Conclusions
The AF genetic risk score was associated with increased AF prevalence in HFrEF and HFpEF. Genetic variation accounted for 22.9% of overall AF SNP heritability. Addition of genetic risk to clinical risk improved model performance in classifying AF prevalence. |
| doi_str_mv | 10.1002/ejhf.1735 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7319410</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2336255927</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4155-bf2d01475334e4dc5b8c34e7b89f41e8d9f51c6f3088fb09382c143593a5b5ed3</originalsourceid><addsrcrecordid>eNp1kM1OAyEURonR2Fpd-AKGpS6mhQE6sDExTX80TdzomjAMONTpTIWpTd9eamujC1d8CSfn3vsBcI1RHyOUDsyitH2cEXYCuphnIkGc0tOYCeeJ4DTtgIsQFgjhLOLnoEOwwEIQ2gWjqalN6zT0LrxDVRdQtd6pClqXe1dVqnVNDV0NVzGZug1w49oSlkb5FlrlqrU3l-DMqiqYq8PbA6-T8ctolsyfp4-jh3miKWYsyW1aIEwzRgg1tNAs5zqmLOfCUmx4ISzDemgJ4tzmSBCeakwJE0SxnJmC9MD93rta50tT6LiOV5VcebdUfisb5eTfn9qV8q35lFm8l2IUBbcHgW8-1ia0cumCNvHK2jTrIFNChiljIs0ierdHtW9C8MYex2Akd6XLXelyV3pkb37vdSR_Wo7AYA9sXGW2_5vk-Gk2-VZ-AYg4jN4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2336255927</pqid></control><display><type>article</type><title>Genetic risk and atrial fibrillation in patients with heart failure</title><source>MEDLINE</source><source>Wiley Journals</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Kloosterman, Mariëlle ; Santema, Bernadet T. ; Roselli, Carolina ; Nelson, Christopher P. ; Koekemoer, Andrea ; Romaine, Simon. P.R. ; Van Gelder, Isabelle C. ; Lam, Carolyn S.P. ; Artola, Vicente A. ; Lang, Chim C. ; Ng, Leon L. ; Metra, Marco ; Anker, Stefan ; Filippatos, Gerasimos ; Dickstein, Kenneth ; Ponikowski, Piotr ; Harst, Pim ; Meer, Peter ; Veldhuisen, Dirk J. ; Benjamin, Emelia J. ; Voors, Adriaan A. ; Samani, Nilesh J. ; Rienstra, Michiel</creator><creatorcontrib>Kloosterman, Mariëlle ; Santema, Bernadet T. ; Roselli, Carolina ; Nelson, Christopher P. ; Koekemoer, Andrea ; Romaine, Simon. P.R. ; Van Gelder, Isabelle C. ; Lam, Carolyn S.P. ; Artola, Vicente A. ; Lang, Chim C. ; Ng, Leon L. ; Metra, Marco ; Anker, Stefan ; Filippatos, Gerasimos ; Dickstein, Kenneth ; Ponikowski, Piotr ; Harst, Pim ; Meer, Peter ; Veldhuisen, Dirk J. ; Benjamin, Emelia J. ; Voors, Adriaan A. ; Samani, Nilesh J. ; Rienstra, Michiel</creatorcontrib><description>Aims
To study the association between an atrial fibrillation (AF) genetic risk score with prevalent AF and all‐cause mortality in patients with heart failure.
Methods and results
An AF genetic risk score was calculated in 3759 European ancestry individuals (1783 with sinus rhythm, 1976 with AF) from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) by summing 97 single nucleotide polymorphism (SNP) alleles (ranging from 0–2) weighted by the natural logarithm of the relative SNP risk from the latest AF genome‐wide association study. Further, we assessed AF risk variance explained by additive SNP variation, and performance of clinical or genetic risk factors, and the combination in classifying AF prevalence. AF was classified as AF or atrial flutter (AFL) at baseline electrocardiogram and/or a history of AF or AFL. The genetic risk score was associated with AF after multivariable adjustment. Odds ratio for AF prevalence per 1‐unit increase genetic risk score was 2.12 (95% confidence interval 1.84–2.45, P = 2.15 × 10−24) in the total cohort, 2.08 (1.72–2.50, P = 1.30 × 10−14) in heart failure with reduced ejection fraction (HFrEF) and 2.02 (1.37–2.99, P = 4.37 × 10−4) in heart failure with preserved ejection fraction (HFpEF). AF‐associated loci explained 22.9% of overall AF SNP heritability. Addition of the genetic risk score to clinical risk factors increased the C‐index by 2.2% to 0.721.
Conclusions
The AF genetic risk score was associated with increased AF prevalence in HFrEF and HFpEF. Genetic variation accounted for 22.9% of overall AF SNP heritability. Addition of genetic risk to clinical risk improved model performance in classifying AF prevalence.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1002/ejhf.1735</identifier><identifier>PMID: 31919934</identifier><language>eng</language><publisher>Oxford, UK: John Wiley & Sons, Ltd</publisher><subject>Aged ; Aged, 80 and over ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Atrial Fibrillation ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - genetics ; Female ; Genetic association studies ; Genome-Wide Association Study ; Heart failure ; Heart Failure - epidemiology ; Heart Failure - genetics ; Humans ; Middle Aged ; Prognosis ; Risk Factors ; Single nucleotide polymorphism ; Stroke Volume ; Ventricular Function, Left</subject><ispartof>European journal of heart failure, 2020-03, Vol.22 (3), p.519-527</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.</rights><rights>2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.</rights><rights>2020 UMCG. published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4155-bf2d01475334e4dc5b8c34e7b89f41e8d9f51c6f3088fb09382c143593a5b5ed3</citedby><cites>FETCH-LOGICAL-c4155-bf2d01475334e4dc5b8c34e7b89f41e8d9f51c6f3088fb09382c143593a5b5ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejhf.1735$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejhf.1735$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31919934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kloosterman, Mariëlle</creatorcontrib><creatorcontrib>Santema, Bernadet T.</creatorcontrib><creatorcontrib>Roselli, Carolina</creatorcontrib><creatorcontrib>Nelson, Christopher P.</creatorcontrib><creatorcontrib>Koekemoer, Andrea</creatorcontrib><creatorcontrib>Romaine, Simon. P.R.</creatorcontrib><creatorcontrib>Van Gelder, Isabelle C.</creatorcontrib><creatorcontrib>Lam, Carolyn S.P.</creatorcontrib><creatorcontrib>Artola, Vicente A.</creatorcontrib><creatorcontrib>Lang, Chim C.</creatorcontrib><creatorcontrib>Ng, Leon L.</creatorcontrib><creatorcontrib>Metra, Marco</creatorcontrib><creatorcontrib>Anker, Stefan</creatorcontrib><creatorcontrib>Filippatos, Gerasimos</creatorcontrib><creatorcontrib>Dickstein, Kenneth</creatorcontrib><creatorcontrib>Ponikowski, Piotr</creatorcontrib><creatorcontrib>Harst, Pim</creatorcontrib><creatorcontrib>Meer, Peter</creatorcontrib><creatorcontrib>Veldhuisen, Dirk J.</creatorcontrib><creatorcontrib>Benjamin, Emelia J.</creatorcontrib><creatorcontrib>Voors, Adriaan A.</creatorcontrib><creatorcontrib>Samani, Nilesh J.</creatorcontrib><creatorcontrib>Rienstra, Michiel</creatorcontrib><title>Genetic risk and atrial fibrillation in patients with heart failure</title><title>European journal of heart failure</title><addtitle>Eur J Heart Fail</addtitle><description>Aims
To study the association between an atrial fibrillation (AF) genetic risk score with prevalent AF and all‐cause mortality in patients with heart failure.
Methods and results
An AF genetic risk score was calculated in 3759 European ancestry individuals (1783 with sinus rhythm, 1976 with AF) from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) by summing 97 single nucleotide polymorphism (SNP) alleles (ranging from 0–2) weighted by the natural logarithm of the relative SNP risk from the latest AF genome‐wide association study. Further, we assessed AF risk variance explained by additive SNP variation, and performance of clinical or genetic risk factors, and the combination in classifying AF prevalence. AF was classified as AF or atrial flutter (AFL) at baseline electrocardiogram and/or a history of AF or AFL. The genetic risk score was associated with AF after multivariable adjustment. Odds ratio for AF prevalence per 1‐unit increase genetic risk score was 2.12 (95% confidence interval 1.84–2.45, P = 2.15 × 10−24) in the total cohort, 2.08 (1.72–2.50, P = 1.30 × 10−14) in heart failure with reduced ejection fraction (HFrEF) and 2.02 (1.37–2.99, P = 4.37 × 10−4) in heart failure with preserved ejection fraction (HFpEF). AF‐associated loci explained 22.9% of overall AF SNP heritability. Addition of the genetic risk score to clinical risk factors increased the C‐index by 2.2% to 0.721.
Conclusions
The AF genetic risk score was associated with increased AF prevalence in HFrEF and HFpEF. Genetic variation accounted for 22.9% of overall AF SNP heritability. Addition of genetic risk to clinical risk improved model performance in classifying AF prevalence.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiotensin Receptor Antagonists</subject><subject>Angiotensin-Converting Enzyme Inhibitors</subject><subject>Atrial Fibrillation</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Atrial Fibrillation - genetics</subject><subject>Female</subject><subject>Genetic association studies</subject><subject>Genome-Wide Association Study</subject><subject>Heart failure</subject><subject>Heart Failure - epidemiology</subject><subject>Heart Failure - genetics</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Single nucleotide polymorphism</subject><subject>Stroke Volume</subject><subject>Ventricular Function, Left</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kM1OAyEURonR2Fpd-AKGpS6mhQE6sDExTX80TdzomjAMONTpTIWpTd9eamujC1d8CSfn3vsBcI1RHyOUDsyitH2cEXYCuphnIkGc0tOYCeeJ4DTtgIsQFgjhLOLnoEOwwEIQ2gWjqalN6zT0LrxDVRdQtd6pClqXe1dVqnVNDV0NVzGZug1w49oSlkb5FlrlqrU3l-DMqiqYq8PbA6-T8ctolsyfp4-jh3miKWYsyW1aIEwzRgg1tNAs5zqmLOfCUmx4ISzDemgJ4tzmSBCeakwJE0SxnJmC9MD93rta50tT6LiOV5VcebdUfisb5eTfn9qV8q35lFm8l2IUBbcHgW8-1ia0cumCNvHK2jTrIFNChiljIs0ierdHtW9C8MYex2Akd6XLXelyV3pkb37vdSR_Wo7AYA9sXGW2_5vk-Gk2-VZ-AYg4jN4</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Kloosterman, Mariëlle</creator><creator>Santema, Bernadet T.</creator><creator>Roselli, Carolina</creator><creator>Nelson, Christopher P.</creator><creator>Koekemoer, Andrea</creator><creator>Romaine, Simon. P.R.</creator><creator>Van Gelder, Isabelle C.</creator><creator>Lam, Carolyn S.P.</creator><creator>Artola, Vicente A.</creator><creator>Lang, Chim C.</creator><creator>Ng, Leon L.</creator><creator>Metra, Marco</creator><creator>Anker, Stefan</creator><creator>Filippatos, Gerasimos</creator><creator>Dickstein, Kenneth</creator><creator>Ponikowski, Piotr</creator><creator>Harst, Pim</creator><creator>Meer, Peter</creator><creator>Veldhuisen, Dirk J.</creator><creator>Benjamin, Emelia J.</creator><creator>Voors, Adriaan A.</creator><creator>Samani, Nilesh J.</creator><creator>Rienstra, Michiel</creator><general>John Wiley & Sons, Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202003</creationdate><title>Genetic risk and atrial fibrillation in patients with heart failure</title><author>Kloosterman, Mariëlle ; Santema, Bernadet T. ; Roselli, Carolina ; Nelson, Christopher P. ; Koekemoer, Andrea ; Romaine, Simon. P.R. ; Van Gelder, Isabelle C. ; Lam, Carolyn S.P. ; Artola, Vicente A. ; Lang, Chim C. ; Ng, Leon L. ; Metra, Marco ; Anker, Stefan ; Filippatos, Gerasimos ; Dickstein, Kenneth ; Ponikowski, Piotr ; Harst, Pim ; Meer, Peter ; Veldhuisen, Dirk J. ; Benjamin, Emelia J. ; Voors, Adriaan A. ; Samani, Nilesh J. ; Rienstra, Michiel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4155-bf2d01475334e4dc5b8c34e7b89f41e8d9f51c6f3088fb09382c143593a5b5ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiotensin Receptor Antagonists</topic><topic>Angiotensin-Converting Enzyme Inhibitors</topic><topic>Atrial Fibrillation</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Atrial Fibrillation - genetics</topic><topic>Female</topic><topic>Genetic association studies</topic><topic>Genome-Wide Association Study</topic><topic>Heart failure</topic><topic>Heart Failure - epidemiology</topic><topic>Heart Failure - genetics</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Single nucleotide polymorphism</topic><topic>Stroke Volume</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kloosterman, Mariëlle</creatorcontrib><creatorcontrib>Santema, Bernadet T.</creatorcontrib><creatorcontrib>Roselli, Carolina</creatorcontrib><creatorcontrib>Nelson, Christopher P.</creatorcontrib><creatorcontrib>Koekemoer, Andrea</creatorcontrib><creatorcontrib>Romaine, Simon. P.R.</creatorcontrib><creatorcontrib>Van Gelder, Isabelle C.</creatorcontrib><creatorcontrib>Lam, Carolyn S.P.</creatorcontrib><creatorcontrib>Artola, Vicente A.</creatorcontrib><creatorcontrib>Lang, Chim C.</creatorcontrib><creatorcontrib>Ng, Leon L.</creatorcontrib><creatorcontrib>Metra, Marco</creatorcontrib><creatorcontrib>Anker, Stefan</creatorcontrib><creatorcontrib>Filippatos, Gerasimos</creatorcontrib><creatorcontrib>Dickstein, Kenneth</creatorcontrib><creatorcontrib>Ponikowski, Piotr</creatorcontrib><creatorcontrib>Harst, Pim</creatorcontrib><creatorcontrib>Meer, Peter</creatorcontrib><creatorcontrib>Veldhuisen, Dirk J.</creatorcontrib><creatorcontrib>Benjamin, Emelia J.</creatorcontrib><creatorcontrib>Voors, Adriaan A.</creatorcontrib><creatorcontrib>Samani, Nilesh J.</creatorcontrib><creatorcontrib>Rienstra, Michiel</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of heart failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kloosterman, Mariëlle</au><au>Santema, Bernadet T.</au><au>Roselli, Carolina</au><au>Nelson, Christopher P.</au><au>Koekemoer, Andrea</au><au>Romaine, Simon. P.R.</au><au>Van Gelder, Isabelle C.</au><au>Lam, Carolyn S.P.</au><au>Artola, Vicente A.</au><au>Lang, Chim C.</au><au>Ng, Leon L.</au><au>Metra, Marco</au><au>Anker, Stefan</au><au>Filippatos, Gerasimos</au><au>Dickstein, Kenneth</au><au>Ponikowski, Piotr</au><au>Harst, Pim</au><au>Meer, Peter</au><au>Veldhuisen, Dirk J.</au><au>Benjamin, Emelia J.</au><au>Voors, Adriaan A.</au><au>Samani, Nilesh J.</au><au>Rienstra, Michiel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic risk and atrial fibrillation in patients with heart failure</atitle><jtitle>European journal of heart failure</jtitle><addtitle>Eur J Heart Fail</addtitle><date>2020-03</date><risdate>2020</risdate><volume>22</volume><issue>3</issue><spage>519</spage><epage>527</epage><pages>519-527</pages><issn>1388-9842</issn><eissn>1879-0844</eissn><abstract>Aims
To study the association between an atrial fibrillation (AF) genetic risk score with prevalent AF and all‐cause mortality in patients with heart failure.
Methods and results
An AF genetic risk score was calculated in 3759 European ancestry individuals (1783 with sinus rhythm, 1976 with AF) from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) by summing 97 single nucleotide polymorphism (SNP) alleles (ranging from 0–2) weighted by the natural logarithm of the relative SNP risk from the latest AF genome‐wide association study. Further, we assessed AF risk variance explained by additive SNP variation, and performance of clinical or genetic risk factors, and the combination in classifying AF prevalence. AF was classified as AF or atrial flutter (AFL) at baseline electrocardiogram and/or a history of AF or AFL. The genetic risk score was associated with AF after multivariable adjustment. Odds ratio for AF prevalence per 1‐unit increase genetic risk score was 2.12 (95% confidence interval 1.84–2.45, P = 2.15 × 10−24) in the total cohort, 2.08 (1.72–2.50, P = 1.30 × 10−14) in heart failure with reduced ejection fraction (HFrEF) and 2.02 (1.37–2.99, P = 4.37 × 10−4) in heart failure with preserved ejection fraction (HFpEF). AF‐associated loci explained 22.9% of overall AF SNP heritability. Addition of the genetic risk score to clinical risk factors increased the C‐index by 2.2% to 0.721.
Conclusions
The AF genetic risk score was associated with increased AF prevalence in HFrEF and HFpEF. Genetic variation accounted for 22.9% of overall AF SNP heritability. Addition of genetic risk to clinical risk improved model performance in classifying AF prevalence.</abstract><cop>Oxford, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>31919934</pmid><doi>10.1002/ejhf.1735</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1388-9842 |
| ispartof | European journal of heart failure, 2020-03, Vol.22 (3), p.519-527 |
| issn | 1388-9842 1879-0844 |
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| subjects | Aged Aged, 80 and over Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Atrial Fibrillation Atrial Fibrillation - epidemiology Atrial Fibrillation - genetics Female Genetic association studies Genome-Wide Association Study Heart failure Heart Failure - epidemiology Heart Failure - genetics Humans Middle Aged Prognosis Risk Factors Single nucleotide polymorphism Stroke Volume Ventricular Function, Left |
| title | Genetic risk and atrial fibrillation in patients with heart failure |
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