Ultrasound can differentiate inclusion body myositis from disease mimics
Introduction The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases. M...
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| Veröffentlicht in: | Muscle & nerve 2020-06, Vol.61 (6), p.783-788 |
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| creator | Leeuwenberg, Kristofoor E. Alfen, Nens Christopher‐Stine, Lisa Paik, Julie J. Tiniakou, Eleni Mecoli, Christopher Doorduin, Jonne Saris, Christiaan G.J. Albayda, Jemima |
| description | Introduction
The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases.
Methods
Patients 50 years of age and older were included from two specialty centers. Muscle echogenicity and muscle thickness of four characteristically involved muscles in IBM were measured and compared with polymyositis (PM)/dermatomyositis (DM), other neuromuscular disorders, and healthy controls.
Results
Echogenicity was higher and muscle thickness generally lower in all four muscles in IBM compared with PM/DM and normal controls. When comparing IBM with the comparator groups, the flexor digitorum profundus was the most discriminative muscle.
Discussion
Ultrasound appears to be a good test to differentiate established IBM from PM/DM and neuromuscular controls, with value as a diagnostic tool for IBM. |
| doi_str_mv | 10.1002/mus.26875 |
| format | Article |
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The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases.
Methods
Patients 50 years of age and older were included from two specialty centers. Muscle echogenicity and muscle thickness of four characteristically involved muscles in IBM were measured and compared with polymyositis (PM)/dermatomyositis (DM), other neuromuscular disorders, and healthy controls.
Results
Echogenicity was higher and muscle thickness generally lower in all four muscles in IBM compared with PM/DM and normal controls. When comparing IBM with the comparator groups, the flexor digitorum profundus was the most discriminative muscle.
Discussion
Ultrasound appears to be a good test to differentiate established IBM from PM/DM and neuromuscular controls, with value as a diagnostic tool for IBM.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26875</identifier><identifier>PMID: 32239702</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Clinical Research Short Report ; Clinical Research Short Reports ; Dermatomyositis ; diagnosis ; Diagnostic software ; Diagnostic systems ; Disorders ; echogenicity ; inclusion body myositis ; Inflammatory diseases ; Medical diagnosis ; Mimicry ; Muscles ; Musculoskeletal diseases ; Myositis ; Neuromuscular diseases ; neuromuscular disorders ; Polymyositis ; quantitative muscle ultrasound ; Thickness ; Ultrasonic imaging ; Ultrasound</subject><ispartof>Muscle & nerve, 2020-06, Vol.61 (6), p.783-788</ispartof><rights>2020 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2020 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5095-1ef975b7375296ea24e1bd69affb527442dc0ad2d699b8d11a3c7618b0cecc2f3</citedby><cites>FETCH-LOGICAL-c5095-1ef975b7375296ea24e1bd69affb527442dc0ad2d699b8d11a3c7618b0cecc2f3</cites><orcidid>0000-0002-8030-9504</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26875$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26875$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32239702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leeuwenberg, Kristofoor E.</creatorcontrib><creatorcontrib>Alfen, Nens</creatorcontrib><creatorcontrib>Christopher‐Stine, Lisa</creatorcontrib><creatorcontrib>Paik, Julie J.</creatorcontrib><creatorcontrib>Tiniakou, Eleni</creatorcontrib><creatorcontrib>Mecoli, Christopher</creatorcontrib><creatorcontrib>Doorduin, Jonne</creatorcontrib><creatorcontrib>Saris, Christiaan G.J.</creatorcontrib><creatorcontrib>Albayda, Jemima</creatorcontrib><title>Ultrasound can differentiate inclusion body myositis from disease mimics</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction
The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases.
Methods
Patients 50 years of age and older were included from two specialty centers. Muscle echogenicity and muscle thickness of four characteristically involved muscles in IBM were measured and compared with polymyositis (PM)/dermatomyositis (DM), other neuromuscular disorders, and healthy controls.
Results
Echogenicity was higher and muscle thickness generally lower in all four muscles in IBM compared with PM/DM and normal controls. When comparing IBM with the comparator groups, the flexor digitorum profundus was the most discriminative muscle.
Discussion
Ultrasound appears to be a good test to differentiate established IBM from PM/DM and neuromuscular controls, with value as a diagnostic tool for IBM.</description><subject>Clinical Research Short Report</subject><subject>Clinical Research Short Reports</subject><subject>Dermatomyositis</subject><subject>diagnosis</subject><subject>Diagnostic software</subject><subject>Diagnostic systems</subject><subject>Disorders</subject><subject>echogenicity</subject><subject>inclusion body myositis</subject><subject>Inflammatory diseases</subject><subject>Medical diagnosis</subject><subject>Mimicry</subject><subject>Muscles</subject><subject>Musculoskeletal diseases</subject><subject>Myositis</subject><subject>Neuromuscular diseases</subject><subject>neuromuscular disorders</subject><subject>Polymyositis</subject><subject>quantitative muscle ultrasound</subject><subject>Thickness</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kUFLHDEUx0Ox1HXbg19ABrzUw6wvycwkuQgiVQuWHtqF3kImk2iWyWRNZpT99s2yutiCpwfv_fjxf_wROsawwADk3E9pQRrO6g9ohkGwsqoFP0AzwBUvGyr-HKKjlFYAgHnDPqFDSggVDMgM3S77MaoUpqErtBqKzllrohlGp0ZTuEH3U3JhKNrQbQq_CcmNLhU2Bp_RZFQyhXfe6fQZfbSqT-bLy5yj5fW331e35d3Pm-9Xl3elrkHUJTZWsLpllNVENEaRyuC2a4Sytq0JqyrSaVAdySvR8g5jRTVrMG9BG62JpXN0sfOup9abTueoUfVyHZ1XcSODcvLfy-Ae5H14koxixoFlwdcXQQyPk0mj9C5p0_dqMGFKklBeM-AMaEZP_0NXYYpDfk-SCiimgucxR2c7SseQUjR2HwaD3PYj_Va77SezJ2_T78nXQjJwvgOeXW8275vkj-WvnfIvFfCb5A</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Leeuwenberg, Kristofoor E.</creator><creator>Alfen, Nens</creator><creator>Christopher‐Stine, Lisa</creator><creator>Paik, Julie J.</creator><creator>Tiniakou, Eleni</creator><creator>Mecoli, Christopher</creator><creator>Doorduin, Jonne</creator><creator>Saris, Christiaan G.J.</creator><creator>Albayda, Jemima</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8030-9504</orcidid></search><sort><creationdate>202006</creationdate><title>Ultrasound can differentiate inclusion body myositis from disease mimics</title><author>Leeuwenberg, Kristofoor E. ; Alfen, Nens ; Christopher‐Stine, Lisa ; Paik, Julie J. ; Tiniakou, Eleni ; Mecoli, Christopher ; Doorduin, Jonne ; Saris, Christiaan G.J. ; Albayda, Jemima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5095-1ef975b7375296ea24e1bd69affb527442dc0ad2d699b8d11a3c7618b0cecc2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Clinical Research Short Report</topic><topic>Clinical Research Short Reports</topic><topic>Dermatomyositis</topic><topic>diagnosis</topic><topic>Diagnostic software</topic><topic>Diagnostic systems</topic><topic>Disorders</topic><topic>echogenicity</topic><topic>inclusion body myositis</topic><topic>Inflammatory diseases</topic><topic>Medical diagnosis</topic><topic>Mimicry</topic><topic>Muscles</topic><topic>Musculoskeletal diseases</topic><topic>Myositis</topic><topic>Neuromuscular diseases</topic><topic>neuromuscular disorders</topic><topic>Polymyositis</topic><topic>quantitative muscle ultrasound</topic><topic>Thickness</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leeuwenberg, Kristofoor E.</creatorcontrib><creatorcontrib>Alfen, Nens</creatorcontrib><creatorcontrib>Christopher‐Stine, Lisa</creatorcontrib><creatorcontrib>Paik, Julie J.</creatorcontrib><creatorcontrib>Tiniakou, Eleni</creatorcontrib><creatorcontrib>Mecoli, Christopher</creatorcontrib><creatorcontrib>Doorduin, Jonne</creatorcontrib><creatorcontrib>Saris, Christiaan G.J.</creatorcontrib><creatorcontrib>Albayda, Jemima</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leeuwenberg, Kristofoor E.</au><au>Alfen, Nens</au><au>Christopher‐Stine, Lisa</au><au>Paik, Julie J.</au><au>Tiniakou, Eleni</au><au>Mecoli, Christopher</au><au>Doorduin, Jonne</au><au>Saris, Christiaan G.J.</au><au>Albayda, Jemima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasound can differentiate inclusion body myositis from disease mimics</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2020-06</date><risdate>2020</risdate><volume>61</volume><issue>6</issue><spage>783</spage><epage>788</epage><pages>783-788</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Introduction
The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases.
Methods
Patients 50 years of age and older were included from two specialty centers. Muscle echogenicity and muscle thickness of four characteristically involved muscles in IBM were measured and compared with polymyositis (PM)/dermatomyositis (DM), other neuromuscular disorders, and healthy controls.
Results
Echogenicity was higher and muscle thickness generally lower in all four muscles in IBM compared with PM/DM and normal controls. When comparing IBM with the comparator groups, the flexor digitorum profundus was the most discriminative muscle.
Discussion
Ultrasound appears to be a good test to differentiate established IBM from PM/DM and neuromuscular controls, with value as a diagnostic tool for IBM.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32239702</pmid><doi>10.1002/mus.26875</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8030-9504</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Clinical Research Short Report Clinical Research Short Reports Dermatomyositis diagnosis Diagnostic software Diagnostic systems Disorders echogenicity inclusion body myositis Inflammatory diseases Medical diagnosis Mimicry Muscles Musculoskeletal diseases Myositis Neuromuscular diseases neuromuscular disorders Polymyositis quantitative muscle ultrasound Thickness Ultrasonic imaging Ultrasound |
| title | Ultrasound can differentiate inclusion body myositis from disease mimics |
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