A prospective clinical study of detailed neurological manifestations in patients with COVID-19
Background COVID-19 is a virus pandemic. According to the first obtained data, COVID-19 has defined with findings such as cough, fever, diarrhea, and fatigue although neurological symptoms of patients with COVID-19 have not been investigated in detail. This study aims to investigate the neurological...
Gespeichert in:
| Veröffentlicht in: | Neurological sciences 2020-08, Vol.41 (8), p.1991-1995 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1995 |
|---|---|
| container_issue | 8 |
| container_start_page | 1991 |
| container_title | Neurological sciences |
| container_volume | 41 |
| creator | Karadaş, Ömer Öztürk, Bilgin Sonkaya, Ali Rıza |
| description | Background
COVID-19 is a virus pandemic. According to the first obtained data, COVID-19 has defined with findings such as cough, fever, diarrhea, and fatigue although neurological symptoms of patients with COVID-19 have not been investigated in detail. This study aims to investigate the neurological findings via obtained face-to-face anamnesis and detailed neurological examination in patients with COVID-19.
Methods
Two hundred thirty-nine consecutive inpatients with COVID-19, supported with laboratory tests, were evaluated. Detailed neurological examinations and evaluations of all patients were performed. All evaluations and examinations were performed by two neurologists who have at least five-year experience.
Results
This study was carried out 239 patients (133 male + 106 female) with diagnosed COVID-19. Neurological findings were present in 83 of 239 patients (34.7%). The most common neurological finding was a headache (27.6%). D-dimer blood levels were detected to be significantly higher in patients with at least one neurological symptom than patients without the neurological symptom (
p
|
| doi_str_mv | 10.1007/s10072-020-04547-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7316428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2425988078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-9586cc69dbb07be965c525fc77d0001bf062b3f62a6d34b696d70ad907f2bf613</originalsourceid><addsrcrecordid>eNp9UUtv1DAYtBCIlsIf4IAsceES8NvOBalaWqhUqRfgiOX4sXWVtYOdFPXf43SX8jhwsT9pxvPNeAB4idFbjJB8V9eTdIigDjHOZCcfgWPMe9RRJtXjw4yVZEfgWa03CCHMMH0KjijhSlEhj8G3UziVXCdv53jroR1jitaMsM6Lu4M5QOdnE0fvYPJLyWPe3sM7k2LwdTZzzKnCmODURp_mCn_E-Rpurr5efOhw_xw8CWas_sXhPgFfzs8-bz51l1cfLzanl51lks1dz5WwVvRuGJAcfC-45YQHK6VbTQ8BCTLQIIgRjrJB9MJJZFyPZCBDEJiegPd73WkZdt7Z5qSYUU8l7ky509lE_TeS4rXe5lstKRaMqCbw5iBQ8velJdO7WK0fR5N8XqomDCuMJVeyUV__Q73JS0ktXmMR3iuF5CpI9izbvrcWHx7MYKTX4vS-Pt3q0_f16VX61Z8xHp786qsR6J5QG5S2vvze_R_Zn3i6pmw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2425988078</pqid></control><display><type>article</type><title>A prospective clinical study of detailed neurological manifestations in patients with COVID-19</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Karadaş, Ömer ; Öztürk, Bilgin ; Sonkaya, Ali Rıza</creator><creatorcontrib>Karadaş, Ömer ; Öztürk, Bilgin ; Sonkaya, Ali Rıza</creatorcontrib><description>Background
COVID-19 is a virus pandemic. According to the first obtained data, COVID-19 has defined with findings such as cough, fever, diarrhea, and fatigue although neurological symptoms of patients with COVID-19 have not been investigated in detail. This study aims to investigate the neurological findings via obtained face-to-face anamnesis and detailed neurological examination in patients with COVID-19.
Methods
Two hundred thirty-nine consecutive inpatients with COVID-19, supported with laboratory tests, were evaluated. Detailed neurological examinations and evaluations of all patients were performed. All evaluations and examinations were performed by two neurologists who have at least five-year experience.
Results
This study was carried out 239 patients (133 male + 106 female) with diagnosed COVID-19. Neurological findings were present in 83 of 239 patients (34.7%). The most common neurological finding was a headache (27.6%). D-dimer blood levels were detected to be significantly higher in patients with at least one neurological symptom than patients without the neurological symptom (
p
< 0.05). IL-6 level was found to be significantly higher in patients with headache than without headache (
p
< 0.05). Creatine kinase (CK) level was detected to be significantly higher in patients with muscle pain (
p
< 0.05).
Conclusion
Neurological symptoms are often seen in patients with COVID-19. Headache was the most common seen neurological symptom in this disease. Dizziness, impaired consciousness, smell and gustation impairments, cerebrovascular disorders, epileptic seizures, and myalgia were detected as other findings apart from the headache. It is suggested that determining these neurological symptoms prevents the diagnosis delay and helps to prohibit virus spread.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-020-04547-7</identifier><identifier>PMID: 32588367</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; Blood levels ; Cerebrovascular diseases ; Coronavirus Infections - complications ; Coronaviruses ; Cough ; COVID-19 ; Creatine ; Creatine kinase ; Diarrhea ; Epilepsy ; Female ; Fever ; Headache ; Headaches ; Humans ; Interleukin 6 ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myalgia ; Nervous System Diseases - virology ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Pandemics ; Pneumonia, Viral - complications ; Prospective Studies ; Psychiatry ; SARS-CoV-2 ; Seizures ; Young Adult</subject><ispartof>Neurological sciences, 2020-08, Vol.41 (8), p.1991-1995</ispartof><rights>Fondazione Società Italiana di Neurologia 2020</rights><rights>Fondazione Società Italiana di Neurologia 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9586cc69dbb07be965c525fc77d0001bf062b3f62a6d34b696d70ad907f2bf613</citedby><cites>FETCH-LOGICAL-c474t-9586cc69dbb07be965c525fc77d0001bf062b3f62a6d34b696d70ad907f2bf613</cites><orcidid>0000-0002-8899-9925 ; 0000-0001-9218-4502 ; 0000-0003-0457-3722</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-020-04547-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-020-04547-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,778,782,883,27913,27914,41477,42546,51308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32588367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karadaş, Ömer</creatorcontrib><creatorcontrib>Öztürk, Bilgin</creatorcontrib><creatorcontrib>Sonkaya, Ali Rıza</creatorcontrib><title>A prospective clinical study of detailed neurological manifestations in patients with COVID-19</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Background
COVID-19 is a virus pandemic. According to the first obtained data, COVID-19 has defined with findings such as cough, fever, diarrhea, and fatigue although neurological symptoms of patients with COVID-19 have not been investigated in detail. This study aims to investigate the neurological findings via obtained face-to-face anamnesis and detailed neurological examination in patients with COVID-19.
Methods
Two hundred thirty-nine consecutive inpatients with COVID-19, supported with laboratory tests, were evaluated. Detailed neurological examinations and evaluations of all patients were performed. All evaluations and examinations were performed by two neurologists who have at least five-year experience.
Results
This study was carried out 239 patients (133 male + 106 female) with diagnosed COVID-19. Neurological findings were present in 83 of 239 patients (34.7%). The most common neurological finding was a headache (27.6%). D-dimer blood levels were detected to be significantly higher in patients with at least one neurological symptom than patients without the neurological symptom (
p
< 0.05). IL-6 level was found to be significantly higher in patients with headache than without headache (
p
< 0.05). Creatine kinase (CK) level was detected to be significantly higher in patients with muscle pain (
p
< 0.05).
Conclusion
Neurological symptoms are often seen in patients with COVID-19. Headache was the most common seen neurological symptom in this disease. Dizziness, impaired consciousness, smell and gustation impairments, cerebrovascular disorders, epileptic seizures, and myalgia were detected as other findings apart from the headache. It is suggested that determining these neurological symptoms prevents the diagnosis delay and helps to prohibit virus spread.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Betacoronavirus</subject><subject>Blood levels</subject><subject>Cerebrovascular diseases</subject><subject>Coronavirus Infections - complications</subject><subject>Coronaviruses</subject><subject>Cough</subject><subject>COVID-19</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Diarrhea</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Fever</subject><subject>Headache</subject><subject>Headaches</subject><subject>Humans</subject><subject>Interleukin 6</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myalgia</subject><subject>Nervous System Diseases - virology</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Pandemics</subject><subject>Pneumonia, Viral - complications</subject><subject>Prospective Studies</subject><subject>Psychiatry</subject><subject>SARS-CoV-2</subject><subject>Seizures</subject><subject>Young Adult</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UUtv1DAYtBCIlsIf4IAsceES8NvOBalaWqhUqRfgiOX4sXWVtYOdFPXf43SX8jhwsT9pxvPNeAB4idFbjJB8V9eTdIigDjHOZCcfgWPMe9RRJtXjw4yVZEfgWa03CCHMMH0KjijhSlEhj8G3UziVXCdv53jroR1jitaMsM6Lu4M5QOdnE0fvYPJLyWPe3sM7k2LwdTZzzKnCmODURp_mCn_E-Rpurr5efOhw_xw8CWas_sXhPgFfzs8-bz51l1cfLzanl51lks1dz5WwVvRuGJAcfC-45YQHK6VbTQ8BCTLQIIgRjrJB9MJJZFyPZCBDEJiegPd73WkZdt7Z5qSYUU8l7ky509lE_TeS4rXe5lstKRaMqCbw5iBQ8velJdO7WK0fR5N8XqomDCuMJVeyUV__Q73JS0ktXmMR3iuF5CpI9izbvrcWHx7MYKTX4vS-Pt3q0_f16VX61Z8xHp786qsR6J5QG5S2vvze_R_Zn3i6pmw</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Karadaş, Ömer</creator><creator>Öztürk, Bilgin</creator><creator>Sonkaya, Ali Rıza</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8899-9925</orcidid><orcidid>https://orcid.org/0000-0001-9218-4502</orcidid><orcidid>https://orcid.org/0000-0003-0457-3722</orcidid></search><sort><creationdate>20200801</creationdate><title>A prospective clinical study of detailed neurological manifestations in patients with COVID-19</title><author>Karadaş, Ömer ; Öztürk, Bilgin ; Sonkaya, Ali Rıza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9586cc69dbb07be965c525fc77d0001bf062b3f62a6d34b696d70ad907f2bf613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Betacoronavirus</topic><topic>Blood levels</topic><topic>Cerebrovascular diseases</topic><topic>Coronavirus Infections - complications</topic><topic>Coronaviruses</topic><topic>Cough</topic><topic>COVID-19</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Diarrhea</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Fever</topic><topic>Headache</topic><topic>Headaches</topic><topic>Humans</topic><topic>Interleukin 6</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myalgia</topic><topic>Nervous System Diseases - virology</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Pandemics</topic><topic>Pneumonia, Viral - complications</topic><topic>Prospective Studies</topic><topic>Psychiatry</topic><topic>SARS-CoV-2</topic><topic>Seizures</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karadaş, Ömer</creatorcontrib><creatorcontrib>Öztürk, Bilgin</creatorcontrib><creatorcontrib>Sonkaya, Ali Rıza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karadaş, Ömer</au><au>Öztürk, Bilgin</au><au>Sonkaya, Ali Rıza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective clinical study of detailed neurological manifestations in patients with COVID-19</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>41</volume><issue>8</issue><spage>1991</spage><epage>1995</epage><pages>1991-1995</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Background
COVID-19 is a virus pandemic. According to the first obtained data, COVID-19 has defined with findings such as cough, fever, diarrhea, and fatigue although neurological symptoms of patients with COVID-19 have not been investigated in detail. This study aims to investigate the neurological findings via obtained face-to-face anamnesis and detailed neurological examination in patients with COVID-19.
Methods
Two hundred thirty-nine consecutive inpatients with COVID-19, supported with laboratory tests, were evaluated. Detailed neurological examinations and evaluations of all patients were performed. All evaluations and examinations were performed by two neurologists who have at least five-year experience.
Results
This study was carried out 239 patients (133 male + 106 female) with diagnosed COVID-19. Neurological findings were present in 83 of 239 patients (34.7%). The most common neurological finding was a headache (27.6%). D-dimer blood levels were detected to be significantly higher in patients with at least one neurological symptom than patients without the neurological symptom (
p
< 0.05). IL-6 level was found to be significantly higher in patients with headache than without headache (
p
< 0.05). Creatine kinase (CK) level was detected to be significantly higher in patients with muscle pain (
p
< 0.05).
Conclusion
Neurological symptoms are often seen in patients with COVID-19. Headache was the most common seen neurological symptom in this disease. Dizziness, impaired consciousness, smell and gustation impairments, cerebrovascular disorders, epileptic seizures, and myalgia were detected as other findings apart from the headache. It is suggested that determining these neurological symptoms prevents the diagnosis delay and helps to prohibit virus spread.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32588367</pmid><doi>10.1007/s10072-020-04547-7</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8899-9925</orcidid><orcidid>https://orcid.org/0000-0001-9218-4502</orcidid><orcidid>https://orcid.org/0000-0003-0457-3722</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1590-1874 |
| ispartof | Neurological sciences, 2020-08, Vol.41 (8), p.1991-1995 |
| issn | 1590-1874 1590-3478 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7316428 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Aged, 80 and over Betacoronavirus Blood levels Cerebrovascular diseases Coronavirus Infections - complications Coronaviruses Cough COVID-19 Creatine Creatine kinase Diarrhea Epilepsy Female Fever Headache Headaches Humans Interleukin 6 Male Medicine Medicine & Public Health Middle Aged Myalgia Nervous System Diseases - virology Neurology Neuroradiology Neurosciences Neurosurgery Pandemics Pneumonia, Viral - complications Prospective Studies Psychiatry SARS-CoV-2 Seizures Young Adult |
| title | A prospective clinical study of detailed neurological manifestations in patients with COVID-19 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A29%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20prospective%20clinical%20study%20of%20detailed%20neurological%20manifestations%20in%20patients%20with%20COVID-19&rft.jtitle=Neurological%20sciences&rft.au=Karada%C5%9F,%20%C3%96mer&rft.date=2020-08-01&rft.volume=41&rft.issue=8&rft.spage=1991&rft.epage=1995&rft.pages=1991-1995&rft.issn=1590-1874&rft.eissn=1590-3478&rft_id=info:doi/10.1007/s10072-020-04547-7&rft_dat=%3Cproquest_pubme%3E2425988078%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2425988078&rft_id=info:pmid/32588367&rfr_iscdi=true |