Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir

Pregnancy is associated with physiological changes that may impact drug pharmacokinetics (PK). The goals of this study were to build maternal‐fetal physiologically based pharmacokinetic (PBPK) models for acyclovir and emtricitabine, 2 anti(retro)viral drugs with active renal net secretion, and to (1...

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Veröffentlicht in:	Journal of clinical pharmacology 2020-02, Vol.60 (2), p.240-255
Hauptverfasser:	Liu, Xiaomei I., Momper, Jeremiah D., Rakhmanina, Natella, den Anker, John N., Green, Dionna J., Burckart, Gilbert J., Best, Brookie M., Mirochnick, Mark, Capparelli, Edmund V., Dallmann, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir Acyclovir - blood Acyclovir - pharmacokinetics Adult Anti-HIV Agents - blood Anti-HIV Agents - pharmacokinetics Antiretroviral drugs Antiviral Agents - blood Antiviral Agents - pharmacokinetics Antiviral drugs Clinical Trials as Topic Computer Simulation Decision making Drug Administration Schedule Drug development Drugs Emtricitabine Emtricitabine - blood Emtricitabine - pharmacokinetics Female Fetus - metabolism Fetuses Humans Maternal-Fetal Exchange Models, Biological PBPK modeling Permeability Pharmacokinetics Placenta Placenta - metabolism Pregnancy Pregnancy - blood Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - metabolism Pregnancy Trimesters - metabolism Prenatal exposure Renal Elimination Umbilical vein Umbilical Veins - metabolism
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