Cytomegalovirus Coinfection Is Associated with Increased Vascular-Homing CD57 + CD4 T Cells in HIV Infection

Cytotoxic CD4 T cells are linked to cardiovascular morbidities and accumulate in both HIV and CMV infections, both of which are associated with increased risk of cardiovascular disease (CVD). In this study, we identify CMV coinfection as a major driver of the cytotoxic phenotype, characterized by el...

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Veröffentlicht in:	The Journal of immunology (1950) 2020-05, Vol.204 (10), p.2722-2733
Hauptverfasser:	Chen, Bonnie, Morris, Stephen R, Panigrahi, Soumya, Michaelson, Gillian M, Wyrick, Jonathan M, Komissarov, Alexey A, Potashnikova, Daria, Lebedeva, Anna, Younes, Souheil-Antoine, Harth, Karem, Kashyap, Vikram S, Vasilieva, Elena, Margolis, Leonid, Zidar, David A, Sieg, Scott F, Shive, Carey L, Funderburg, Nicholas T, Gianella, Sara, Lederman, Michael M, Freeman, Michael L
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Vessels - physiology CD28 Antigens - metabolism CD4-Positive T-Lymphocytes - immunology CD57 Antigens - metabolism CD58 Antigens - metabolism Cell Movement Chemokine CX3CL1 - metabolism Coinfection CX3C Chemokine Receptor 1 - metabolism Cytomegalovirus - physiology Cytomegalovirus Infections - immunology Cytotoxicity, Immunologic HIV Infections - immunology HIV-1 - physiology Humans Plaque, Atherosclerotic - immunology Receptors, CXCR3 - metabolism Risk
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