Chemiluminescence resonance energy transfer-based nanoparticles for quantum yield-enhanced cancer phototheranostics
Chemiluminescence (CL) has recently gained attention for CL resonance energy transfer (CRET)-mediated photodynamic therapy of cancer. However, the short duration of the CL signal and low quantum yield of the photosensitizer have limited its translational applications. Here, we report CRET-based nano...
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| Veröffentlicht in: | Science advances 2020-05, Vol.6 (21), p.eaaz8400-eaaz8400 |
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| creator | Jeon, Jueun You, Dong Gil Um, Wooram Lee, Jeongjin Kim, Chan Ho Shin, Sol Kwon, Seunglee Park, Jae Hyung |
| description | Chemiluminescence (CL) has recently gained attention for CL resonance energy transfer (CRET)-mediated photodynamic therapy of cancer. However, the short duration of the CL signal and low quantum yield of the photosensitizer have limited its translational applications. Here, we report CRET-based nanoparticles (CRET-NPs) to achieve quantum yield-enhanced cancer phototheranostics by reinterpreting the hidden nature of CRET. Owing to reactive oxygen species (ROS)-responsive CO
generation, CRET-NPs were capable of generating a strong and long-lasting photoacoustic signal in the tumor tissue via thermal expansion-induced vaporization. In addition, the CRET phenomenon of the NPs enhanced ROS quantum yield of photosensitizer through both electron transfer for an oxygen-independent type I photochemical reaction and self-illumination for an oxygen-dependent type II photochemical reaction. Consequently, owing to their high ROS quantum yield, CRET-NPs effectively inhibited tumor growth with complete tumor growth inhibition in 60% of cases, even with a single treatment. |
| doi_str_mv | 10.1126/sciadv.aaz8400 |
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generation, CRET-NPs were capable of generating a strong and long-lasting photoacoustic signal in the tumor tissue via thermal expansion-induced vaporization. In addition, the CRET phenomenon of the NPs enhanced ROS quantum yield of photosensitizer through both electron transfer for an oxygen-independent type I photochemical reaction and self-illumination for an oxygen-dependent type II photochemical reaction. Consequently, owing to their high ROS quantum yield, CRET-NPs effectively inhibited tumor growth with complete tumor growth inhibition in 60% of cases, even with a single treatment.</description><identifier>ISSN: 2375-2548</identifier><identifier>EISSN: 2375-2548</identifier><identifier>DOI: 10.1126/sciadv.aaz8400</identifier><identifier>PMID: 32637587</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Applied Physics ; Health and Medicine ; SciAdv r-articles</subject><ispartof>Science advances, 2020-05, Vol.6 (21), p.eaaz8400-eaaz8400</ispartof><rights>Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).</rights><rights>Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). 2020 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-ddf3982af23e3d20fde04adce59284118487839109dc13531cbbd537b1885283</citedby><cites>FETCH-LOGICAL-c390t-ddf3982af23e3d20fde04adce59284118487839109dc13531cbbd537b1885283</cites><orcidid>0000-0003-2479-0783 ; 0000-0003-1888-1216 ; 0000-0002-9508-6454 ; 0000-0003-4943-8102 ; 0000-0001-7811-2254 ; 0000-0002-5043-9455 ; 0000-0002-5421-0404 ; 0000-0002-3261-1928</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314564/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314564/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32637587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Jueun</creatorcontrib><creatorcontrib>You, Dong Gil</creatorcontrib><creatorcontrib>Um, Wooram</creatorcontrib><creatorcontrib>Lee, Jeongjin</creatorcontrib><creatorcontrib>Kim, Chan Ho</creatorcontrib><creatorcontrib>Shin, Sol</creatorcontrib><creatorcontrib>Kwon, Seunglee</creatorcontrib><creatorcontrib>Park, Jae Hyung</creatorcontrib><title>Chemiluminescence resonance energy transfer-based nanoparticles for quantum yield-enhanced cancer phototheranostics</title><title>Science advances</title><addtitle>Sci Adv</addtitle><description>Chemiluminescence (CL) has recently gained attention for CL resonance energy transfer (CRET)-mediated photodynamic therapy of cancer. However, the short duration of the CL signal and low quantum yield of the photosensitizer have limited its translational applications. Here, we report CRET-based nanoparticles (CRET-NPs) to achieve quantum yield-enhanced cancer phototheranostics by reinterpreting the hidden nature of CRET. Owing to reactive oxygen species (ROS)-responsive CO
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| subjects | Applied Physics Health and Medicine SciAdv r-articles |
| title | Chemiluminescence resonance energy transfer-based nanoparticles for quantum yield-enhanced cancer phototheranostics |
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