Cross-Reactivity of Palladium in a Murine Model of Metal-Induced Allergic Contact Dermatitis
Metal allergy is usually diagnosed by patch testing, however, the results do not necessarily reflect the clinical symptoms because of cross-reactivity between different metals. In this study, we established the novel mouse model of cross-reactive metal allergy, and aimed to elucidate the immune resp...
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| Veröffentlicht in: | International journal of molecular sciences 2020-06, Vol.21 (11), p.4061 |
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| creator | Shigematsu, Hiroaki Kumagai, Kenichi Suzuki, Motoaki Eguchi, Takanori Matsubara, Ryota Nakasone, Yasunari Nasu, Keisuke Yoshizawa, Takamasa Ichikawa, Haruno Mori, Takahiro Hamada, Yoshiki Suzuki, Ryuji |
| description | Metal allergy is usually diagnosed by patch testing, however, the results do not necessarily reflect the clinical symptoms because of cross-reactivity between different metals. In this study, we established the novel mouse model of cross-reactive metal allergy, and aimed to elucidate the immune response in terms of T-cell receptor repertoire. This model was classified into two groups: the sensitization to nickel and challenge with palladium group, and the sensitization to chromium and challenge with palladium group. This model developed spongiotic edema with intra- and peri-epithelial infiltration of CD4
T cells in the inflamed skin that resembles human contact dermatitis. Using T cell receptor analysis, we detected a high proportion of T cells bearing
and
in the Ni- and Cr-sensitized Pd-challenged mice. Furthermore, mucosal-associated invariant T cells and invariant natural killer T cells were also detected. Our results indicated that T cells bearing
and
induced the development of palladium-cross reactive allergy, and that mucosal-associated invariant T and invariant natural killer T cells were also involved in the cross-reactivity between different metals. |
| doi_str_mv | 10.3390/ijms21114061 |
| format | Article |
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T cells in the inflamed skin that resembles human contact dermatitis. Using T cell receptor analysis, we detected a high proportion of T cells bearing
and
in the Ni- and Cr-sensitized Pd-challenged mice. Furthermore, mucosal-associated invariant T cells and invariant natural killer T cells were also detected. Our results indicated that T cells bearing
and
induced the development of palladium-cross reactive allergy, and that mucosal-associated invariant T and invariant natural killer T cells were also involved in the cross-reactivity between different metals.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21114061</identifier><identifier>PMID: 32517103</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Allergens - immunology ; Allergies ; Animal models ; Animals ; Antigens ; Apoptosis ; Bone surgery ; CD4 antigen ; Chromium ; Cloning ; Contact dermatitis ; Cross Reactions - immunology ; Cross-reactivity ; Cytokines ; Cytotoxicity ; Dermatitis ; Dermatitis, Allergic Contact - etiology ; Disease Models, Animal ; Disease Susceptibility ; Eczema ; Edema ; Hypersensitivity ; Immunohistochemistry ; Inflammation ; Invariants ; Lymphocytes ; Lymphocytes T ; Metals ; Metals, Heavy - adverse effects ; Mice ; Mucosa ; Natural killer cells ; Palladium ; Palladium - adverse effects ; Reactivity ; Receptors, Antigen, T-Cell - metabolism ; Studies ; T cell receptors ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2020-06, Vol.21 (11), p.4061</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-3780f6f5c5c9ff3f7906ada512bf24120437561948c5eefe9f5c7b693f9c993a3</citedby><cites>FETCH-LOGICAL-c478t-3780f6f5c5c9ff3f7906ada512bf24120437561948c5eefe9f5c7b693f9c993a3</cites><orcidid>0000-0003-4608-1347 ; 0000-0001-7324-8574</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313072/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313072/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32517103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shigematsu, Hiroaki</creatorcontrib><creatorcontrib>Kumagai, Kenichi</creatorcontrib><creatorcontrib>Suzuki, Motoaki</creatorcontrib><creatorcontrib>Eguchi, Takanori</creatorcontrib><creatorcontrib>Matsubara, Ryota</creatorcontrib><creatorcontrib>Nakasone, Yasunari</creatorcontrib><creatorcontrib>Nasu, Keisuke</creatorcontrib><creatorcontrib>Yoshizawa, Takamasa</creatorcontrib><creatorcontrib>Ichikawa, Haruno</creatorcontrib><creatorcontrib>Mori, Takahiro</creatorcontrib><creatorcontrib>Hamada, Yoshiki</creatorcontrib><creatorcontrib>Suzuki, Ryuji</creatorcontrib><title>Cross-Reactivity of Palladium in a Murine Model of Metal-Induced Allergic Contact Dermatitis</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Metal allergy is usually diagnosed by patch testing, however, the results do not necessarily reflect the clinical symptoms because of cross-reactivity between different metals. In this study, we established the novel mouse model of cross-reactive metal allergy, and aimed to elucidate the immune response in terms of T-cell receptor repertoire. This model was classified into two groups: the sensitization to nickel and challenge with palladium group, and the sensitization to chromium and challenge with palladium group. This model developed spongiotic edema with intra- and peri-epithelial infiltration of CD4
T cells in the inflamed skin that resembles human contact dermatitis. Using T cell receptor analysis, we detected a high proportion of T cells bearing
and
in the Ni- and Cr-sensitized Pd-challenged mice. Furthermore, mucosal-associated invariant T cells and invariant natural killer T cells were also detected. Our results indicated that T cells bearing
and
induced the development of palladium-cross reactive allergy, and that mucosal-associated invariant T and invariant natural killer T cells were also involved in the cross-reactivity between different metals.</description><subject>Allergens - immunology</subject><subject>Allergies</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>Bone surgery</subject><subject>CD4 antigen</subject><subject>Chromium</subject><subject>Cloning</subject><subject>Contact dermatitis</subject><subject>Cross Reactions - immunology</subject><subject>Cross-reactivity</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Dermatitis</subject><subject>Dermatitis, Allergic Contact - etiology</subject><subject>Disease Models, Animal</subject><subject>Disease Susceptibility</subject><subject>Eczema</subject><subject>Edema</subject><subject>Hypersensitivity</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Invariants</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Metals</subject><subject>Metals, Heavy - 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In this study, we established the novel mouse model of cross-reactive metal allergy, and aimed to elucidate the immune response in terms of T-cell receptor repertoire. This model was classified into two groups: the sensitization to nickel and challenge with palladium group, and the sensitization to chromium and challenge with palladium group. This model developed spongiotic edema with intra- and peri-epithelial infiltration of CD4
T cells in the inflamed skin that resembles human contact dermatitis. Using T cell receptor analysis, we detected a high proportion of T cells bearing
and
in the Ni- and Cr-sensitized Pd-challenged mice. Furthermore, mucosal-associated invariant T cells and invariant natural killer T cells were also detected. Our results indicated that T cells bearing
and
induced the development of palladium-cross reactive allergy, and that mucosal-associated invariant T and invariant natural killer T cells were also involved in the cross-reactivity between different metals.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32517103</pmid><doi>10.3390/ijms21114061</doi><orcidid>https://orcid.org/0000-0003-4608-1347</orcidid><orcidid>https://orcid.org/0000-0001-7324-8574</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Allergens - immunology Allergies Animal models Animals Antigens Apoptosis Bone surgery CD4 antigen Chromium Cloning Contact dermatitis Cross Reactions - immunology Cross-reactivity Cytokines Cytotoxicity Dermatitis Dermatitis, Allergic Contact - etiology Disease Models, Animal Disease Susceptibility Eczema Edema Hypersensitivity Immunohistochemistry Inflammation Invariants Lymphocytes Lymphocytes T Metals Metals, Heavy - adverse effects Mice Mucosa Natural killer cells Palladium Palladium - adverse effects Reactivity Receptors, Antigen, T-Cell - metabolism Studies T cell receptors T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor necrosis factor-TNF |
| title | Cross-Reactivity of Palladium in a Murine Model of Metal-Induced Allergic Contact Dermatitis |
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