β-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke

Chronic treatment involving opioids exacerbates both the risk and severity of ischemic stroke. We have provided experimental evidence showing the anti-inflammatory and neuroprotective effects of the μ opioid receptor antagonist β-funaltrexamine for neurodegenerative diseases in rat neuron/glia cultu...

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Veröffentlicht in:	International journal of molecular sciences 2020-05, Vol.21 (11), p.3866
Hauptverfasser:	Wu, Chih-Cheng, Chang, Cheng-Yi, Shih, Kuei-Chung, Hung, Chih-Jen, Wang, Ya-Yu, Lin, Shih-Yi, Chen, Wen-Ying, Kuan, Yu-Hsiang, Liao, Su-Lan, Wang, Wen-Yi, Chen, Chun-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Arginase - metabolism Brain - cytology Brain - drug effects Brain - metabolism Cells, Cultured Cyclic AMP Response Element-Binding Protein - metabolism Dinoprostone - metabolism Interferon-gamma - pharmacology Interleukin-1beta - metabolism Lipopolysaccharides - pharmacology Male Naltrexone - analogs & derivatives Naltrexone - pharmacology Naltrexone - therapeutic use Neuroglia - drug effects Neuroglia - metabolism Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-kappa B - metabolism Nitric Oxide - metabolism Rats Rats, Sprague-Dawley Receptors, Cell Surface - metabolism Stroke - drug therapy Tumor Necrosis Factor-alpha - metabolism
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