Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury

NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and autophagy induction attenuate inflammation and improve outcome in rodent models of cerebral ischemia. However, the impact of chronic stress on NLRP3 inflammasome and autophagic response to ischemia remains unknown. Proge...

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Veröffentlicht in:	International journal of molecular sciences 2020-05, Vol.21 (11), p.3740
Hauptverfasser:	Espinosa-Garcia, Claudia, Atif, Fahim, Yousuf, Seema, Sayeed, Iqbal, Neigh, Gretchen N, Stein, Donald G
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine triphosphate Animal models Animals Anti-Inflammatory Agents - pharmacology Autophagy Brain injury Brain Ischemia - complications Brain Ischemia - metabolism Cells, Cultured Cerebral blood flow Comorbidity Hippocampus Hippocampus - drug effects Hippocampus - metabolism HMGB1 protein IL-1β Inflammasomes Inflammation Injury prevention Interleukin-1beta - metabolism Ischemia Lipopolysaccharides Male Microglia Microglia - drug effects Microglia - metabolism Molecular modelling Neonates Neuroprotection Neuroprotective Agents - pharmacology Neurotoxicity NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Phagocytosis Pretreatment Progesterone Progesterone - pharmacology Pyrin protein Rats Rats, Sprague-Dawley Social interactions Steroids Stress, Psychological - complications Stress, Psychological - metabolism Synergistic effect Traumatic brain injury
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