Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease
This study aimed to investigate whether the single nucleotide polymorphism C677T (rs1801133) of the methylene-tetrahydrofolate reductase (MTHFR) gene was associated with the risk of coronary artery disease (CAD) and circulating homocysteine (Hcy) levels in Tunisian population. 310 angiografically di...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-06, Vol.10 (1), p.10064-10064, Article 10064 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10064 |
|---|---|
| container_issue | 1 |
| container_start_page | 10064 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Bouzidi, Nadia Hassine, Majed Fodha, Hajer Ben Messaoud, Mejdi Maatouk, Faouzi Gamra, Habib Ferchichi, Salima |
| description | This study aimed to investigate whether the single nucleotide polymorphism C677T (rs1801133) of the methylene-tetrahydrofolate reductase (MTHFR) gene was associated with the risk of coronary artery disease (CAD) and circulating homocysteine (Hcy) levels in Tunisian population. 310 angiografically diagnosed CAD patients and 210 controls were enrolled in this study. The MTHFR C677T (rs1801133) polymorphism was genotyped, and the Hcy concentrations were measured. The severity of CAD was evaluated using the Gensini scoring system. Compared to the CC genotype, the TT genotype confers a higher risk for CAD severity with an OR = 9.07 and 95% CI = 3.78–21.8. The T allele was the predisposing allele for CAD and that it was probably associated with CAD severity. The area under the ROC curve for Hcy was 0.764 (95% CI 0.660 to 0.868, p = 0.001). The receiver operating characteristics curve (ROC) for Hcy showed its useful prediction of CAD. Hcy levels were not significantly associated with CAD severity expressed by Gensini Score (GS). The MTHFR C677T (rs1801133) polymorphism influences circulating Hcy levels. The MTHFR C677T polymorphism and hyperhomocysteinemia could have an important role in the prediction of the presence and not the severity expressed by GS of CAD. |
| doi_str_mv | 10.1038/s41598-020-66937-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7308346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2416273581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-6c280071374f6d34b5f40eed79f7ed8c3a631441a2c99f0d25f561b3a9c0680c3</originalsourceid><addsrcrecordid>eNp9Uk1v1DAQjRCIVkv_AAdkiQsHAv62c0GqVrQgVeJSzpbXmWxcJXaxna323_BT8XZLKRzwZTyaN-_NaF7TvCb4A8FMf8yciE63mOJWyo6plj1rTinmoqWM0udP_ifNWc43uD5BO066l80Jo0JRrPhp8_M85-i8LT4GFAdURkAzlHE_QYC2QEl23PcpDnGyBVCCfnHFZkDbWkcpE40JYQytpVLXaGeTt6GgO19GlCEtMxrjHN0-F_AVP8EOpvwe2dDfK-WaJ1_2B2UXUww27ZFNBWrofYYq9Kp5Mdgpw9lDXDXfLz5fr7-0V98uv67Pr1rHFS-tdFRjrAhTfJA94xsxcAzQq25Q0GvHrGSEc2Kp67oB91QMQpINs53DUmPHVs2nI-_tspmhdxDq6pO5TX6uQ5lovfm7EvxotnFnFMOacVkJ3j0QpPhjgVzM7LODabIB4pIN5URSxYQmFfr2H-hNXFKo6x1QQkit641XDT2iXIo5JxgehyHYHDxgjh4w1QPm3gOG1aY3T9d4bPl98QpgR0CupbCF9Ef7P7S_ABeYvws</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2415568810</pqid></control><display><type>article</type><title>Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Bouzidi, Nadia ; Hassine, Majed ; Fodha, Hajer ; Ben Messaoud, Mejdi ; Maatouk, Faouzi ; Gamra, Habib ; Ferchichi, Salima</creator><creatorcontrib>Bouzidi, Nadia ; Hassine, Majed ; Fodha, Hajer ; Ben Messaoud, Mejdi ; Maatouk, Faouzi ; Gamra, Habib ; Ferchichi, Salima</creatorcontrib><description>This study aimed to investigate whether the single nucleotide polymorphism C677T (rs1801133) of the methylene-tetrahydrofolate reductase (MTHFR) gene was associated with the risk of coronary artery disease (CAD) and circulating homocysteine (Hcy) levels in Tunisian population. 310 angiografically diagnosed CAD patients and 210 controls were enrolled in this study. The MTHFR C677T (rs1801133) polymorphism was genotyped, and the Hcy concentrations were measured. The severity of CAD was evaluated using the Gensini scoring system. Compared to the CC genotype, the TT genotype confers a higher risk for CAD severity with an OR = 9.07 and 95% CI = 3.78–21.8. The T allele was the predisposing allele for CAD and that it was probably associated with CAD severity. The area under the ROC curve for Hcy was 0.764 (95% CI 0.660 to 0.868, p = 0.001). The receiver operating characteristics curve (ROC) for Hcy showed its useful prediction of CAD. Hcy levels were not significantly associated with CAD severity expressed by Gensini Score (GS). The MTHFR C677T (rs1801133) polymorphism influences circulating Hcy levels. The MTHFR C677T polymorphism and hyperhomocysteinemia could have an important role in the prediction of the presence and not the severity expressed by GS of CAD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-66937-3</identifier><identifier>PMID: 32572074</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/45/147 ; 692/4019/2776 ; 692/4019/592/2727 ; 692/53 ; Adult ; Aged ; Alleles ; Cardiovascular disease ; Case-Control Studies ; Coronary artery ; Coronary Artery Disease - blood ; Coronary Artery Disease - genetics ; Coronary vessels ; Female ; Gene polymorphism ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Health risk assessment ; Heart diseases ; Homocysteine ; Homocysteine - blood ; Humanities and Social Sciences ; Humans ; Hyperhomocysteinemia ; Male ; Methylenetetrahydrofolate reductase ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; multidisciplinary ; Polymorphism ; Polymorphism, Single Nucleotide ; ROC Curve ; Science ; Science (multidisciplinary) ; Severity of Illness Index ; Single-nucleotide polymorphism ; Tetrahydrofolic acid ; Tunisia ; Young Adult</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.10064-10064, Article 10064</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-6c280071374f6d34b5f40eed79f7ed8c3a631441a2c99f0d25f561b3a9c0680c3</citedby><cites>FETCH-LOGICAL-c474t-6c280071374f6d34b5f40eed79f7ed8c3a631441a2c99f0d25f561b3a9c0680c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308346/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308346/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32572074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouzidi, Nadia</creatorcontrib><creatorcontrib>Hassine, Majed</creatorcontrib><creatorcontrib>Fodha, Hajer</creatorcontrib><creatorcontrib>Ben Messaoud, Mejdi</creatorcontrib><creatorcontrib>Maatouk, Faouzi</creatorcontrib><creatorcontrib>Gamra, Habib</creatorcontrib><creatorcontrib>Ferchichi, Salima</creatorcontrib><title>Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This study aimed to investigate whether the single nucleotide polymorphism C677T (rs1801133) of the methylene-tetrahydrofolate reductase (MTHFR) gene was associated with the risk of coronary artery disease (CAD) and circulating homocysteine (Hcy) levels in Tunisian population. 310 angiografically diagnosed CAD patients and 210 controls were enrolled in this study. The MTHFR C677T (rs1801133) polymorphism was genotyped, and the Hcy concentrations were measured. The severity of CAD was evaluated using the Gensini scoring system. Compared to the CC genotype, the TT genotype confers a higher risk for CAD severity with an OR = 9.07 and 95% CI = 3.78–21.8. The T allele was the predisposing allele for CAD and that it was probably associated with CAD severity. The area under the ROC curve for Hcy was 0.764 (95% CI 0.660 to 0.868, p = 0.001). The receiver operating characteristics curve (ROC) for Hcy showed its useful prediction of CAD. Hcy levels were not significantly associated with CAD severity expressed by Gensini Score (GS). The MTHFR C677T (rs1801133) polymorphism influences circulating Hcy levels. The MTHFR C677T polymorphism and hyperhomocysteinemia could have an important role in the prediction of the presence and not the severity expressed by GS of CAD.</description><subject>631/45/147</subject><subject>692/4019/2776</subject><subject>692/4019/592/2727</subject><subject>692/53</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hyperhomocysteinemia</subject><subject>Male</subject><subject>Methylenetetrahydrofolate reductase</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>ROC Curve</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Severity of Illness Index</subject><subject>Single-nucleotide polymorphism</subject><subject>Tetrahydrofolic acid</subject><subject>Tunisia</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9Uk1v1DAQjRCIVkv_AAdkiQsHAv62c0GqVrQgVeJSzpbXmWxcJXaxna323_BT8XZLKRzwZTyaN-_NaF7TvCb4A8FMf8yciE63mOJWyo6plj1rTinmoqWM0udP_ifNWc43uD5BO066l80Jo0JRrPhp8_M85-i8LT4GFAdURkAzlHE_QYC2QEl23PcpDnGyBVCCfnHFZkDbWkcpE40JYQytpVLXaGeTt6GgO19GlCEtMxrjHN0-F_AVP8EOpvwe2dDfK-WaJ1_2B2UXUww27ZFNBWrofYYq9Kp5Mdgpw9lDXDXfLz5fr7-0V98uv67Pr1rHFS-tdFRjrAhTfJA94xsxcAzQq25Q0GvHrGSEc2Kp67oB91QMQpINs53DUmPHVs2nI-_tspmhdxDq6pO5TX6uQ5lovfm7EvxotnFnFMOacVkJ3j0QpPhjgVzM7LODabIB4pIN5URSxYQmFfr2H-hNXFKo6x1QQkit641XDT2iXIo5JxgehyHYHDxgjh4w1QPm3gOG1aY3T9d4bPl98QpgR0CupbCF9Ef7P7S_ABeYvws</recordid><startdate>20200622</startdate><enddate>20200622</enddate><creator>Bouzidi, Nadia</creator><creator>Hassine, Majed</creator><creator>Fodha, Hajer</creator><creator>Ben Messaoud, Mejdi</creator><creator>Maatouk, Faouzi</creator><creator>Gamra, Habib</creator><creator>Ferchichi, Salima</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200622</creationdate><title>Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease</title><author>Bouzidi, Nadia ; Hassine, Majed ; Fodha, Hajer ; Ben Messaoud, Mejdi ; Maatouk, Faouzi ; Gamra, Habib ; Ferchichi, Salima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-6c280071374f6d34b5f40eed79f7ed8c3a631441a2c99f0d25f561b3a9c0680c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/45/147</topic><topic>692/4019/2776</topic><topic>692/4019/592/2727</topic><topic>692/53</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary vessels</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Health risk assessment</topic><topic>Heart diseases</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hyperhomocysteinemia</topic><topic>Male</topic><topic>Methylenetetrahydrofolate reductase</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>ROC Curve</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Severity of Illness Index</topic><topic>Single-nucleotide polymorphism</topic><topic>Tetrahydrofolic acid</topic><topic>Tunisia</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouzidi, Nadia</creatorcontrib><creatorcontrib>Hassine, Majed</creatorcontrib><creatorcontrib>Fodha, Hajer</creatorcontrib><creatorcontrib>Ben Messaoud, Mejdi</creatorcontrib><creatorcontrib>Maatouk, Faouzi</creatorcontrib><creatorcontrib>Gamra, Habib</creatorcontrib><creatorcontrib>Ferchichi, Salima</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouzidi, Nadia</au><au>Hassine, Majed</au><au>Fodha, Hajer</au><au>Ben Messaoud, Mejdi</au><au>Maatouk, Faouzi</au><au>Gamra, Habib</au><au>Ferchichi, Salima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-06-22</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>10064</spage><epage>10064</epage><pages>10064-10064</pages><artnum>10064</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>This study aimed to investigate whether the single nucleotide polymorphism C677T (rs1801133) of the methylene-tetrahydrofolate reductase (MTHFR) gene was associated with the risk of coronary artery disease (CAD) and circulating homocysteine (Hcy) levels in Tunisian population. 310 angiografically diagnosed CAD patients and 210 controls were enrolled in this study. The MTHFR C677T (rs1801133) polymorphism was genotyped, and the Hcy concentrations were measured. The severity of CAD was evaluated using the Gensini scoring system. Compared to the CC genotype, the TT genotype confers a higher risk for CAD severity with an OR = 9.07 and 95% CI = 3.78–21.8. The T allele was the predisposing allele for CAD and that it was probably associated with CAD severity. The area under the ROC curve for Hcy was 0.764 (95% CI 0.660 to 0.868, p = 0.001). The receiver operating characteristics curve (ROC) for Hcy showed its useful prediction of CAD. Hcy levels were not significantly associated with CAD severity expressed by Gensini Score (GS). The MTHFR C677T (rs1801133) polymorphism influences circulating Hcy levels. The MTHFR C677T polymorphism and hyperhomocysteinemia could have an important role in the prediction of the presence and not the severity expressed by GS of CAD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32572074</pmid><doi>10.1038/s41598-020-66937-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-06, Vol.10 (1), p.10064-10064, Article 10064 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7308346 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 631/45/147 692/4019/2776 692/4019/592/2727 692/53 Adult Aged Alleles Cardiovascular disease Case-Control Studies Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - genetics Coronary vessels Female Gene polymorphism Genetic Association Studies Genetic Predisposition to Disease Genotype Health risk assessment Heart diseases Homocysteine Homocysteine - blood Humanities and Social Sciences Humans Hyperhomocysteinemia Male Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged multidisciplinary Polymorphism Polymorphism, Single Nucleotide ROC Curve Science Science (multidisciplinary) Severity of Illness Index Single-nucleotide polymorphism Tetrahydrofolic acid Tunisia Young Adult |
| title | Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T12%3A54%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20the%20methylene-tetrahydrofolate%20reductase%20gene%20rs1801133%20C677T%20variant%20with%20serum%20homocysteine%20levels,%20and%20the%20severity%20of%20coronary%20artery%20disease&rft.jtitle=Scientific%20reports&rft.au=Bouzidi,%20Nadia&rft.date=2020-06-22&rft.volume=10&rft.issue=1&rft.spage=10064&rft.epage=10064&rft.pages=10064-10064&rft.artnum=10064&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-66937-3&rft_dat=%3Cproquest_pubme%3E2416273581%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2415568810&rft_id=info:pmid/32572074&rfr_iscdi=true |