Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery
Smart multifunctional nanoparticles with magnetic and plasmonic properties assembled on a single nanoplatform are promising for various biomedical applications. Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug d...
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| Veröffentlicht in: | Scientific reports 2020-06, Vol.10 (1), p.10115, Article 10115 |
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| creator | Tomitaka, Asahi Arami, Hamed Ahmadivand, Arash Pala, Nezih McGoron, Anthony J. Takemura, Yasushi Febo, Marcelo Nair, Madhavan |
| description | Smart multifunctional nanoparticles with magnetic and plasmonic properties assembled on a single nanoplatform are promising for various biomedical applications. Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine. |
| doi_str_mv | 10.1038/s41598-020-66706-2 |
| format | Article |
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Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-66706-2</identifier><identifier>PMID: 32572041</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/301/357 ; 639/925/350 ; 639/925/352 ; Animals ; Drug delivery ; Drug Delivery Systems - methods ; Drug Liberation - physiology ; Electromagnetic Phenomena ; External stimuli ; Ferric Compounds - chemistry ; Gold ; Humanities and Social Sciences ; Humans ; Iron oxides ; Magnetic Resonance Imaging ; Magnetics ; Magnetite Nanoparticles - chemistry ; multidisciplinary ; Multifunctional Nanoparticles - chemistry ; Multifunctional Nanoparticles - therapeutic use ; Multimodal Imaging ; Nanoparticles ; Phototherapy - methods ; Precision medicine ; Precision Medicine - methods ; Science ; Science (multidisciplinary) ; Simulation analysis</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.10115, Article 10115</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine.</description><subject>639/301/357</subject><subject>639/925/350</subject><subject>639/925/352</subject><subject>Animals</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Liberation - physiology</subject><subject>Electromagnetic Phenomena</subject><subject>External stimuli</subject><subject>Ferric Compounds - chemistry</subject><subject>Gold</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Iron oxides</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetics</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>multidisciplinary</subject><subject>Multifunctional Nanoparticles - chemistry</subject><subject>Multifunctional Nanoparticles - therapeutic use</subject><subject>Multimodal Imaging</subject><subject>Nanoparticles</subject><subject>Phototherapy - 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Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32572041</pmid><doi>10.1038/s41598-020-66706-2</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 639/301/357 639/925/350 639/925/352 Animals Drug delivery Drug Delivery Systems - methods Drug Liberation - physiology Electromagnetic Phenomena External stimuli Ferric Compounds - chemistry Gold Humanities and Social Sciences Humans Iron oxides Magnetic Resonance Imaging Magnetics Magnetite Nanoparticles - chemistry multidisciplinary Multifunctional Nanoparticles - chemistry Multifunctional Nanoparticles - therapeutic use Multimodal Imaging Nanoparticles Phototherapy - methods Precision medicine Precision Medicine - methods Science Science (multidisciplinary) Simulation analysis |
| title | Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery |
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