NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis

DNA double-strand breaks (DSBs) pose a serious threat to genomic stability. Paradoxically, hundreds of programed DSBs are generated by SPO11 in meiotic prophase, which are exclusively repaired by homologous recombination (HR) to promote obligate crossover between homologous chromosomes. In somatic c...

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Veröffentlicht in:	Cell death and differentiation 2020-07, Vol.27 (7), p.2176-2190
Hauptverfasser:	Zhang, Bin, Tang, Zhenghui, Li, Lejun, Lu, Lin-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14/19 631/337 631/80 82/80 Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Chromosomes Deoxyribonucleic acid DNA DNA damage DNA repair Double-strand break repair Germ cells Homologous recombination Infertility Life Sciences Meiosis MRE11 protein Prophase Somatic cells Stem Cells Yeast Zebrafish
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