Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma
Purpose To examine the impact of pre-diagnosis depressive symptoms and mental health-related quality of life (HRQOL) on survival among older patients with multiple myeloma (MM). Methods We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results-Medicare Health Ou...
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| Veröffentlicht in: | Supportive care in cancer 2020-09, Vol.28 (9), p.4097-4106 |
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| creator | Alobaidi, Ali Nabulsi, Nadia A. Talon, Brian Asfaw, Alemseged A. Zhou, Jifang Sharp, Lisa K. Sweiss, Karen Patel, Pritesh R. Ko, Naomi Y. Chiu, Brian C.-H. Calip, Gregory S. |
| description | Purpose
To examine the impact of pre-diagnosis depressive symptoms and mental health-related quality of life (HRQOL) on survival among older patients with multiple myeloma (MM).
Methods
We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey data resource. Patients aged 65 years and older diagnosed with first primary MM between 1998 and 2014 were identified, and presence of depressive symptoms was determined based on responses to 3 depression screening questions prior to MM diagnosis. Veterans RAND 12 mental component summary (MCS) scores were analyzed to evaluate mental HRQOL. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risks of all-cause and cancer-specific mortality.
Results
Of 522 patients, mean (SD) age at diagnosis was 76.9 (6.1) years and 158 (30%) reported depressive symptoms. Patients with depressive symptoms had a higher number of comorbid conditions and nearly all (84%) scored below the median MCS. Pre-diagnosis depressive symptoms were not associated with all-cause (HR = 1.01, 95% CI 0.79–1.29) or cancer-specific mortality (HR = 0.94, 95% CI 0.69–1.28). MM patients scoring in the second MCS tertile (vs the highest tertile) had a modestly increased risk of all-cause (HR = 1.19, 95% CI 0.91–1.55) and cancer-specific mortality (HR = 1.17, 95% CI 0.86–1.60), but these estimates were not statistically significant.
Conclusion
Pre-diagnosis depressive symptoms and lower mental HRQoL did not impact survival among older MM patients. Highly prevalent depressive symptoms among older MM patients deserve clinical attention. Such efforts can inform clinicians in tailoring care for this vulnerable population. |
| doi_str_mv | 10.1007/s00520-019-05246-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7308221</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A630447358</galeid><sourcerecordid>A630447358</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-3035f834a9abe9031035284de31ec67a709a2cce2ef886a5cd4ed5d4c1e07603</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EokvhD3BAlrhwaIq_YicXpKqUD6kSl94t15nsurLj1HYW7b_H2y0tRQj5YI_nmdcz1ovQW0pOKSHqYyakZaQhtG_qQchGPkMrKjhvFOf9c7QivaCN4G17hF7lfEMIVaplL9ERp51irGcrlD_DnCBntwWcd2EuMeQTHGAqxuMNGF82TQJvCgz4djHelR2OI_ZuhBNspgHnJW3dtsImxGmNox8g4dkUVyUy_unKBofFFzd7wGEHPgbzGr0Yjc_w5n4_RldfLq7OvzWXP75-Pz-7bGwraGk44e3YcWF6cw094bTGrBMDcApWKqNIb5i1wGDsOmlaOwgY2kFYCkRJwo_Rp4PsvFwHGGxtKBmv5-SCSTsdjdNPM5Pb6HXcasVJxxitAh_uBVK8XSAXHVy24L2ZIC5ZM15bFJQLWdH3f6E3cUlTnU4zwSSXvezJI7U2HrSbxljftXtRfSY5EULxtqvU6T-ougYIzsYJRlfvnxSwQ4FNMecE48OMlOi9U_TBKbo6Rd85Re87fvfn7zyU_LZGBfgByDU1rSE9jvQf2V-Wacod</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2426369690</pqid></control><display><type>article</type><title>Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Alobaidi, Ali ; Nabulsi, Nadia A. ; Talon, Brian ; Asfaw, Alemseged A. ; Zhou, Jifang ; Sharp, Lisa K. ; Sweiss, Karen ; Patel, Pritesh R. ; Ko, Naomi Y. ; Chiu, Brian C.-H. ; Calip, Gregory S.</creator><creatorcontrib>Alobaidi, Ali ; Nabulsi, Nadia A. ; Talon, Brian ; Asfaw, Alemseged A. ; Zhou, Jifang ; Sharp, Lisa K. ; Sweiss, Karen ; Patel, Pritesh R. ; Ko, Naomi Y. ; Chiu, Brian C.-H. ; Calip, Gregory S.</creatorcontrib><description>Purpose
To examine the impact of pre-diagnosis depressive symptoms and mental health-related quality of life (HRQOL) on survival among older patients with multiple myeloma (MM).
Methods
We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey data resource. Patients aged 65 years and older diagnosed with first primary MM between 1998 and 2014 were identified, and presence of depressive symptoms was determined based on responses to 3 depression screening questions prior to MM diagnosis. Veterans RAND 12 mental component summary (MCS) scores were analyzed to evaluate mental HRQOL. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risks of all-cause and cancer-specific mortality.
Results
Of 522 patients, mean (SD) age at diagnosis was 76.9 (6.1) years and 158 (30%) reported depressive symptoms. Patients with depressive symptoms had a higher number of comorbid conditions and nearly all (84%) scored below the median MCS. Pre-diagnosis depressive symptoms were not associated with all-cause (HR = 1.01, 95% CI 0.79–1.29) or cancer-specific mortality (HR = 0.94, 95% CI 0.69–1.28). MM patients scoring in the second MCS tertile (vs the highest tertile) had a modestly increased risk of all-cause (HR = 1.19, 95% CI 0.91–1.55) and cancer-specific mortality (HR = 1.17, 95% CI 0.86–1.60), but these estimates were not statistically significant.
Conclusion
Pre-diagnosis depressive symptoms and lower mental HRQoL did not impact survival among older MM patients. Highly prevalent depressive symptoms among older MM patients deserve clinical attention. Such efforts can inform clinicians in tailoring care for this vulnerable population.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-019-05246-6</identifier><identifier>PMID: 31872292</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged patients ; Aged, 80 and over ; Analysis ; Cancer ; Cohort Studies ; Depression - psychology ; Depression, Mental ; Epidemiology ; Female ; Health risk assessment ; Humans ; Male ; Medical screening ; Medicine ; Medicine & Public Health ; Mental depression ; Mental health ; Mental Health - trends ; Mortality ; Multiple myeloma ; Multiple Myeloma - mortality ; Multiple Myeloma - psychology ; Nursing ; Nursing Research ; Older people ; Oncology ; Original Article ; Pain Medicine ; Palliative care ; Patient outcomes ; Prospective Studies ; Quality of life ; Quality of Life - psychology ; Rehabilitation Medicine ; Retrospective Studies ; SEER Program ; Surveys ; Treatment Outcome</subject><ispartof>Supportive care in cancer, 2020-09, Vol.28 (9), p.4097-4106</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-3035f834a9abe9031035284de31ec67a709a2cce2ef886a5cd4ed5d4c1e07603</citedby><cites>FETCH-LOGICAL-c541t-3035f834a9abe9031035284de31ec67a709a2cce2ef886a5cd4ed5d4c1e07603</cites><orcidid>0000-0002-7744-3518</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-019-05246-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-019-05246-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31872292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alobaidi, Ali</creatorcontrib><creatorcontrib>Nabulsi, Nadia A.</creatorcontrib><creatorcontrib>Talon, Brian</creatorcontrib><creatorcontrib>Asfaw, Alemseged A.</creatorcontrib><creatorcontrib>Zhou, Jifang</creatorcontrib><creatorcontrib>Sharp, Lisa K.</creatorcontrib><creatorcontrib>Sweiss, Karen</creatorcontrib><creatorcontrib>Patel, Pritesh R.</creatorcontrib><creatorcontrib>Ko, Naomi Y.</creatorcontrib><creatorcontrib>Chiu, Brian C.-H.</creatorcontrib><creatorcontrib>Calip, Gregory S.</creatorcontrib><title>Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
To examine the impact of pre-diagnosis depressive symptoms and mental health-related quality of life (HRQOL) on survival among older patients with multiple myeloma (MM).
Methods
We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey data resource. Patients aged 65 years and older diagnosed with first primary MM between 1998 and 2014 were identified, and presence of depressive symptoms was determined based on responses to 3 depression screening questions prior to MM diagnosis. Veterans RAND 12 mental component summary (MCS) scores were analyzed to evaluate mental HRQOL. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risks of all-cause and cancer-specific mortality.
Results
Of 522 patients, mean (SD) age at diagnosis was 76.9 (6.1) years and 158 (30%) reported depressive symptoms. Patients with depressive symptoms had a higher number of comorbid conditions and nearly all (84%) scored below the median MCS. Pre-diagnosis depressive symptoms were not associated with all-cause (HR = 1.01, 95% CI 0.79–1.29) or cancer-specific mortality (HR = 0.94, 95% CI 0.69–1.28). MM patients scoring in the second MCS tertile (vs the highest tertile) had a modestly increased risk of all-cause (HR = 1.19, 95% CI 0.91–1.55) and cancer-specific mortality (HR = 1.17, 95% CI 0.86–1.60), but these estimates were not statistically significant.
Conclusion
Pre-diagnosis depressive symptoms and lower mental HRQoL did not impact survival among older MM patients. Highly prevalent depressive symptoms among older MM patients deserve clinical attention. Such efforts can inform clinicians in tailoring care for this vulnerable population.</description><subject>Aged</subject><subject>Aged patients</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Depression - psychology</subject><subject>Depression, Mental</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Male</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Mental health</subject><subject>Mental Health - trends</subject><subject>Mortality</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - mortality</subject><subject>Multiple Myeloma - psychology</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Older people</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Palliative care</subject><subject>Patient outcomes</subject><subject>Prospective Studies</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Rehabilitation Medicine</subject><subject>Retrospective Studies</subject><subject>SEER Program</subject><subject>Surveys</subject><subject>Treatment Outcome</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kk1v1DAQhi0EokvhD3BAlrhwaIq_YicXpKqUD6kSl94t15nsurLj1HYW7b_H2y0tRQj5YI_nmdcz1ovQW0pOKSHqYyakZaQhtG_qQchGPkMrKjhvFOf9c7QivaCN4G17hF7lfEMIVaplL9ERp51irGcrlD_DnCBntwWcd2EuMeQTHGAqxuMNGF82TQJvCgz4djHelR2OI_ZuhBNspgHnJW3dtsImxGmNox8g4dkUVyUy_unKBofFFzd7wGEHPgbzGr0Yjc_w5n4_RldfLq7OvzWXP75-Pz-7bGwraGk44e3YcWF6cw094bTGrBMDcApWKqNIb5i1wGDsOmlaOwgY2kFYCkRJwo_Rp4PsvFwHGGxtKBmv5-SCSTsdjdNPM5Pb6HXcasVJxxitAh_uBVK8XSAXHVy24L2ZIC5ZM15bFJQLWdH3f6E3cUlTnU4zwSSXvezJI7U2HrSbxljftXtRfSY5EULxtqvU6T-ougYIzsYJRlfvnxSwQ4FNMecE48OMlOi9U_TBKbo6Rd85Re87fvfn7zyU_LZGBfgByDU1rSE9jvQf2V-Wacod</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Alobaidi, Ali</creator><creator>Nabulsi, Nadia A.</creator><creator>Talon, Brian</creator><creator>Asfaw, Alemseged A.</creator><creator>Zhou, Jifang</creator><creator>Sharp, Lisa K.</creator><creator>Sweiss, Karen</creator><creator>Patel, Pritesh R.</creator><creator>Ko, Naomi Y.</creator><creator>Chiu, Brian C.-H.</creator><creator>Calip, Gregory S.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7744-3518</orcidid></search><sort><creationdate>20200901</creationdate><title>Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma</title><author>Alobaidi, Ali ; Nabulsi, Nadia A. ; Talon, Brian ; Asfaw, Alemseged A. ; Zhou, Jifang ; Sharp, Lisa K. ; Sweiss, Karen ; Patel, Pritesh R. ; Ko, Naomi Y. ; Chiu, Brian C.-H. ; Calip, Gregory S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-3035f834a9abe9031035284de31ec67a709a2cce2ef886a5cd4ed5d4c1e07603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged patients</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Depression - psychology</topic><topic>Depression, Mental</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Male</topic><topic>Medical screening</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Mental health</topic><topic>Mental Health - trends</topic><topic>Mortality</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - mortality</topic><topic>Multiple Myeloma - psychology</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Older people</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Palliative care</topic><topic>Patient outcomes</topic><topic>Prospective Studies</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Rehabilitation Medicine</topic><topic>Retrospective Studies</topic><topic>SEER Program</topic><topic>Surveys</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alobaidi, Ali</creatorcontrib><creatorcontrib>Nabulsi, Nadia A.</creatorcontrib><creatorcontrib>Talon, Brian</creatorcontrib><creatorcontrib>Asfaw, Alemseged A.</creatorcontrib><creatorcontrib>Zhou, Jifang</creatorcontrib><creatorcontrib>Sharp, Lisa K.</creatorcontrib><creatorcontrib>Sweiss, Karen</creatorcontrib><creatorcontrib>Patel, Pritesh R.</creatorcontrib><creatorcontrib>Ko, Naomi Y.</creatorcontrib><creatorcontrib>Chiu, Brian C.-H.</creatorcontrib><creatorcontrib>Calip, Gregory S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alobaidi, Ali</au><au>Nabulsi, Nadia A.</au><au>Talon, Brian</au><au>Asfaw, Alemseged A.</au><au>Zhou, Jifang</au><au>Sharp, Lisa K.</au><au>Sweiss, Karen</au><au>Patel, Pritesh R.</au><au>Ko, Naomi Y.</au><au>Chiu, Brian C.-H.</au><au>Calip, Gregory S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>28</volume><issue>9</issue><spage>4097</spage><epage>4106</epage><pages>4097-4106</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
To examine the impact of pre-diagnosis depressive symptoms and mental health-related quality of life (HRQOL) on survival among older patients with multiple myeloma (MM).
Methods
We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey data resource. Patients aged 65 years and older diagnosed with first primary MM between 1998 and 2014 were identified, and presence of depressive symptoms was determined based on responses to 3 depression screening questions prior to MM diagnosis. Veterans RAND 12 mental component summary (MCS) scores were analyzed to evaluate mental HRQOL. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risks of all-cause and cancer-specific mortality.
Results
Of 522 patients, mean (SD) age at diagnosis was 76.9 (6.1) years and 158 (30%) reported depressive symptoms. Patients with depressive symptoms had a higher number of comorbid conditions and nearly all (84%) scored below the median MCS. Pre-diagnosis depressive symptoms were not associated with all-cause (HR = 1.01, 95% CI 0.79–1.29) or cancer-specific mortality (HR = 0.94, 95% CI 0.69–1.28). MM patients scoring in the second MCS tertile (vs the highest tertile) had a modestly increased risk of all-cause (HR = 1.19, 95% CI 0.91–1.55) and cancer-specific mortality (HR = 1.17, 95% CI 0.86–1.60), but these estimates were not statistically significant.
Conclusion
Pre-diagnosis depressive symptoms and lower mental HRQoL did not impact survival among older MM patients. Highly prevalent depressive symptoms among older MM patients deserve clinical attention. Such efforts can inform clinicians in tailoring care for this vulnerable population.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31872292</pmid><doi>10.1007/s00520-019-05246-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7744-3518</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Supportive care in cancer, 2020-09, Vol.28 (9), p.4097-4106 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Aged patients Aged, 80 and over Analysis Cancer Cohort Studies Depression - psychology Depression, Mental Epidemiology Female Health risk assessment Humans Male Medical screening Medicine Medicine & Public Health Mental depression Mental health Mental Health - trends Mortality Multiple myeloma Multiple Myeloma - mortality Multiple Myeloma - psychology Nursing Nursing Research Older people Oncology Original Article Pain Medicine Palliative care Patient outcomes Prospective Studies Quality of life Quality of Life - psychology Rehabilitation Medicine Retrospective Studies SEER Program Surveys Treatment Outcome |
| title | Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma |
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