Quantification of observable behaviors induced by typical and atypical kappa-opioid receptor agonists in male rhesus monkeys

Rationale Kappa-opioid receptor (KOR) agonists are antinociceptive but have side effects that limit their therapeutic utility. New KOR agonists have been developed that are fully efficacious at the KOR but may produce fewer or reduced side effects that are typical of KOR agonists. Objectives We dete...

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Veröffentlicht in:	Psychopharmacology 2020-07, Vol.237 (7), p.2075-2087
Hauptverfasser:	Huskinson, S. L., Platt, D. M., Brasfield, M., Follett, M. E., Prisinzano, T. E., Blough, B. E., Freeman, K. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology Agonists Analgesics, Opioid - pharmacology Animals Behavior Behavior, Animal - drug effects Behavior, Animal - physiology Biomedical and Life Sciences Biomedicine Cocaine Diterpenes, Clerodane - pharmacology Dose-Response Relationship, Drug Intracellular signalling Ketamine Macaca mulatta Male Morphinans - pharmacology Motor Activity - drug effects Motor Activity - physiology Narcotics Neurophysiology Neurosciences Opioid receptors (type kappa) Opioid receptors (type mu) Original Investigation Oxycodone Oxycodone - pharmacology Pain perception Pharmacology/Toxicology Posture Psychiatry Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - physiology Salvinorin A Side effects Sleep Spiro Compounds - pharmacology Triazoles
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