Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana
2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoate (known as GenX) has been used as an alternative to perfluorooctanoic acid (PFOA) which was phased out of formulations for industrial and consumer product applications in 2015. While the effects of GenX on lab animals have been studied, little is k...
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| Veröffentlicht in: | Environmental pollution (1987) 2020-04, Vol.259, p.113817-113817, Article 113817 |
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| container_title | Environmental pollution (1987) |
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| creator | Chen, Chih-Hung Yang, Shih-Hung Liu, Yina Jamieson, Pierce Shan, Libo Chu, Kung-Hui |
| description | 2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoate (known as GenX) has been used as an alternative to perfluorooctanoic acid (PFOA) which was phased out of formulations for industrial and consumer product applications in 2015. While the effects of GenX on lab animals have been studied, little is known about its effects on plants. This study examined and compared the accumulation and toxicity of GenX and PFOA in the model plants Arabidopsis thaliana and Nicotiana benthamiana. Both plants showed reduction in biomass and root growth following exposure to PFOA or GenX in a dosage-dependent manner. The bioaccumulation factors (BFs) of GenX and PFOA were plant species-dependent, with higher BFs in A. thaliana compared to N. bethanminana. Additionally, GenX and PFOA were more readily accumulated into shoot tissues of A. thaliana than in N. bethanminana. Exposure to GenX also caused a reduction in chlorophyll content (18%) and total phenolic compounds (26%). However, GenX exposure increased superoxide dismutase activity and H2O2 content (1.6 and 2.6 folds increase, respectively) in N. benthamiana. Overall, our result suggest that GenX is bioaccumulative, and that its accumulation likely inhibits plant growth and photosynthesis as well as inducing oxidative stress.
[Display omitted]
•GenX and PFOA inhibit growth of A. thaliana and N. benthamiana.•Bioaccumulation and translocation of GenX and PFOA are plant species-dependent.•Bioaccumulation factor of GenX is higher in A. thaliana than in N. benthamiana.•GenX decreases chlorophyll content and triggers oxidative stress in N. benthamiana. |
| doi_str_mv | 10.1016/j.envpol.2019.113817 |
| format | Article |
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[Display omitted]
•GenX and PFOA inhibit growth of A. thaliana and N. benthamiana.•Bioaccumulation and translocation of GenX and PFOA are plant species-dependent.•Bioaccumulation factor of GenX is higher in A. thaliana than in N. benthamiana.•GenX decreases chlorophyll content and triggers oxidative stress in N. benthamiana.</description><identifier>ISSN: 0269-7491</identifier><identifier>EISSN: 1873-6424</identifier><identifier>DOI: 10.1016/j.envpol.2019.113817</identifier><identifier>PMID: 31918129</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Arabidopsis ; Bioaccumulation ; Biomarkers ; Caprylates - toxicity ; Fluorocarbons - toxicity ; GenX ; Hydrogen Peroxide ; Nicotiana ; PFOA ; Propionates - toxicity ; Translocation</subject><ispartof>Environmental pollution (1987), 2020-04, Vol.259, p.113817-113817, Article 113817</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-3ad55ca2ece71d06a41f14f231fe175c6ae25a437d1d903a328afe3e3d31a3973</citedby><cites>FETCH-LOGICAL-c463t-3ad55ca2ece71d06a41f14f231fe175c6ae25a437d1d903a328afe3e3d31a3973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0269749119354405$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31918129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Chih-Hung</creatorcontrib><creatorcontrib>Yang, Shih-Hung</creatorcontrib><creatorcontrib>Liu, Yina</creatorcontrib><creatorcontrib>Jamieson, Pierce</creatorcontrib><creatorcontrib>Shan, Libo</creatorcontrib><creatorcontrib>Chu, Kung-Hui</creatorcontrib><title>Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana</title><title>Environmental pollution (1987)</title><addtitle>Environ Pollut</addtitle><description>2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoate (known as GenX) has been used as an alternative to perfluorooctanoic acid (PFOA) which was phased out of formulations for industrial and consumer product applications in 2015. While the effects of GenX on lab animals have been studied, little is known about its effects on plants. This study examined and compared the accumulation and toxicity of GenX and PFOA in the model plants Arabidopsis thaliana and Nicotiana benthamiana. Both plants showed reduction in biomass and root growth following exposure to PFOA or GenX in a dosage-dependent manner. The bioaccumulation factors (BFs) of GenX and PFOA were plant species-dependent, with higher BFs in A. thaliana compared to N. bethanminana. Additionally, GenX and PFOA were more readily accumulated into shoot tissues of A. thaliana than in N. bethanminana. Exposure to GenX also caused a reduction in chlorophyll content (18%) and total phenolic compounds (26%). However, GenX exposure increased superoxide dismutase activity and H2O2 content (1.6 and 2.6 folds increase, respectively) in N. benthamiana. Overall, our result suggest that GenX is bioaccumulative, and that its accumulation likely inhibits plant growth and photosynthesis as well as inducing oxidative stress.
[Display omitted]
•GenX and PFOA inhibit growth of A. thaliana and N. benthamiana.•Bioaccumulation and translocation of GenX and PFOA are plant species-dependent.•Bioaccumulation factor of GenX is higher in A. thaliana than in N. benthamiana.•GenX decreases chlorophyll content and triggers oxidative stress in N. benthamiana.</description><subject>Animals</subject><subject>Arabidopsis</subject><subject>Bioaccumulation</subject><subject>Biomarkers</subject><subject>Caprylates - toxicity</subject><subject>Fluorocarbons - toxicity</subject><subject>GenX</subject><subject>Hydrogen Peroxide</subject><subject>Nicotiana</subject><subject>PFOA</subject><subject>Propionates - toxicity</subject><subject>Translocation</subject><issn>0269-7491</issn><issn>1873-6424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGO0zAQhi0EYrsLb4BQjiCR4rGduLkgVStYkFZwgbM1tSfUVWpHjlttn2dflKRZFrggWxqPZv5_xvoYewV8CRzq97slhWMfu6Xg0CwB5Ar0E7aAlZZlrYR6yhZc1E2pVQMX7HIYdpxzJaV8zi4kNLAC0SzY_draw_7QYfYxFBhc0W9POeZ4563PpyK2RU-p7Q4xxWgzhuhtgda7c694J6dTZsoJ56ZSlG-21OeHtB9vvDu9neIoxkyFD8U64ca72A9-KPIWO48Bz4ZfvY35nG0ojJX99H7BnrXYDfTyIV6xH58-fr_-XN5-u_lyvb4traplLiW6qrIoyJIGx2tU0IJqhYSWQFe2RhIVKqkduIZLlGKFLUmSTgLKRssr9mH27Q-bPTk7bpCwM33ye0wnE9GbfyvBb83PeDRacl1pNRqo2cCmOAyJ2kctcDNBMzszQzMTNDNDG2Wv_577KPpN6c9iNP7-6CmZwXoKlpxPZLNx0f9_wi8_XLCC</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Chen, Chih-Hung</creator><creator>Yang, Shih-Hung</creator><creator>Liu, Yina</creator><creator>Jamieson, Pierce</creator><creator>Shan, Libo</creator><creator>Chu, Kung-Hui</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200401</creationdate><title>Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana</title><author>Chen, Chih-Hung ; Yang, Shih-Hung ; Liu, Yina ; Jamieson, Pierce ; Shan, Libo ; Chu, Kung-Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-3ad55ca2ece71d06a41f14f231fe175c6ae25a437d1d903a328afe3e3d31a3973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Arabidopsis</topic><topic>Bioaccumulation</topic><topic>Biomarkers</topic><topic>Caprylates - toxicity</topic><topic>Fluorocarbons - toxicity</topic><topic>GenX</topic><topic>Hydrogen Peroxide</topic><topic>Nicotiana</topic><topic>PFOA</topic><topic>Propionates - toxicity</topic><topic>Translocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chih-Hung</creatorcontrib><creatorcontrib>Yang, Shih-Hung</creatorcontrib><creatorcontrib>Liu, Yina</creatorcontrib><creatorcontrib>Jamieson, Pierce</creatorcontrib><creatorcontrib>Shan, Libo</creatorcontrib><creatorcontrib>Chu, Kung-Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental pollution (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chih-Hung</au><au>Yang, Shih-Hung</au><au>Liu, Yina</au><au>Jamieson, Pierce</au><au>Shan, Libo</au><au>Chu, Kung-Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana</atitle><jtitle>Environmental pollution (1987)</jtitle><addtitle>Environ Pollut</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>259</volume><spage>113817</spage><epage>113817</epage><pages>113817-113817</pages><artnum>113817</artnum><issn>0269-7491</issn><eissn>1873-6424</eissn><abstract>2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoate (known as GenX) has been used as an alternative to perfluorooctanoic acid (PFOA) which was phased out of formulations for industrial and consumer product applications in 2015. While the effects of GenX on lab animals have been studied, little is known about its effects on plants. This study examined and compared the accumulation and toxicity of GenX and PFOA in the model plants Arabidopsis thaliana and Nicotiana benthamiana. Both plants showed reduction in biomass and root growth following exposure to PFOA or GenX in a dosage-dependent manner. The bioaccumulation factors (BFs) of GenX and PFOA were plant species-dependent, with higher BFs in A. thaliana compared to N. bethanminana. Additionally, GenX and PFOA were more readily accumulated into shoot tissues of A. thaliana than in N. bethanminana. Exposure to GenX also caused a reduction in chlorophyll content (18%) and total phenolic compounds (26%). However, GenX exposure increased superoxide dismutase activity and H2O2 content (1.6 and 2.6 folds increase, respectively) in N. benthamiana. Overall, our result suggest that GenX is bioaccumulative, and that its accumulation likely inhibits plant growth and photosynthesis as well as inducing oxidative stress.
[Display omitted]
•GenX and PFOA inhibit growth of A. thaliana and N. benthamiana.•Bioaccumulation and translocation of GenX and PFOA are plant species-dependent.•Bioaccumulation factor of GenX is higher in A. thaliana than in N. benthamiana.•GenX decreases chlorophyll content and triggers oxidative stress in N. benthamiana.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31918129</pmid><doi>10.1016/j.envpol.2019.113817</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental pollution (1987), 2020-04, Vol.259, p.113817-113817, Article 113817 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Arabidopsis Bioaccumulation Biomarkers Caprylates - toxicity Fluorocarbons - toxicity GenX Hydrogen Peroxide Nicotiana PFOA Propionates - toxicity Translocation |
| title | Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana |
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