Medical Conditions Linked to Atherosclerosis Are Associated With Magnified Cortical Thinning in Individuals With Alcohol Use Disorders
Abstract Aims Magnetic resonance imaging (MRI) studies report widespread cortical thinning in individuals with alcohol use disorder (AUD), but did not consider potential effects of pro-atherogenic conditions such as hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemi...
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| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2020-06, Vol.55 (4), p.382-390 |
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| creator | Durazzo, Timothy C Nguyen, Linh-Chi Meyerhoff, Dieter J |
| description | Abstract
Aims
Magnetic resonance imaging (MRI) studies report widespread cortical thinning in individuals with alcohol use disorder (AUD), but did not consider potential effects of pro-atherogenic conditions such as hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia on cortical thickness. The conditions are associated with regional cortical thinning in those without AUD. We predicted that individuals with concurrent AUD and pro-atherogenic conditions demonstrate the greatest regional cortical thinning in areas most vulnerable to decreased perfusion.
Methods
Treatment-seeking individuals with AUD (n = 126) and healthy controls (CON; n = 49) completed a 1.5 T MRI study. Regional cortical thickness was quantitated via FreeSurfer. Individuals with AUD and pro-atherogenic conditions (Atherogenic+), AUD without pro-atherogenic conditions (Atherogenic−) and CON were compared on regional cortical thickness.
Results
Individuals with AUD showed significant bilateral cortical thinning compared to CON, but Atherogenic+ demonstrated the most widespread and greatest magnitude of regional thinning, while Atherogenic− had reduced thickness primarily in anterior frontal and posterior parietal lobes. Atherogenic+ also showed a thinner cortex than Atherogenic− in lateral orbitofrontal and dorso/dorsolateral frontal cortex, mesial and lateral temporal and inferior parietal regions.
Conclusions
Our results demonstrate significant bilateral cortical thinning in individuals with AUD relative to CON, but the distribution and magnitude were influenced by comorbid pro-atherogenic conditions. The magnitude of cortical thinning in Atherogenic+ strongly corresponded to cortical watershed areas susceptible to decreased perfusion, which may result in morphometric abnormalities. The findings indicate that pro-atherogenic conditions may contribute to cortical thinning in those seeking treatment for AUD.
Individuals with an alcohol use disorder (AUD) and comorbid pro-atherogenic conditions of hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia showed significantly greater cortical thinning in multiple regions compared to AUD without pro-atherogenic conditions and healthy controls. Findings indicated pro-atherogenic conditions may exacerbate brain structural deficits in AUD. |
| doi_str_mv | 10.1093/alcalc/agaa034 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7307314</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/alcalc/agaa034</oup_id><sourcerecordid>2406304636</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-1009052cb11389de781154e0098242aec5504b794934ba3fdfb898f4ebe197093</originalsourceid><addsrcrecordid>eNqFkcFu1DAURS0EosPAliXyEhZp7fhlkmyQoqFApanYtGJpOc7L5EHGHuykEj_Ad9clQwUrpMiR7eNj617GXktxLkWtLsxo03dh9sYIBU_YSsIGMlWI_ClbiVIVmQAJZ-xFjN-EkKBy-ZydqRygUKpYsV_X2FFS8K13HU3kXeQ7ct-x45PnzTRg8NGODyNF3gTkTYzekpkS8ZWmgV-bvaOe0nTrw_TbdTOQc-T2nBy_Sto76mYzxoVvRusHP_LbiPwDRR86DPEle9YnAl-d_mt2-_HyZvs52335dLVtdpmFHKZMClGLIretlKqqOywrKQvAtFrlkBu0RSGgLWuoFbRG9V3fVnXVA7Yo6zLltWbvF-9xbg_YWXRTMKM-BjqY8FN7Q_rfHUeD3vs7XaoUZopvzd6eBMH_mDFO-kDR4jgah36OOgexUQI2apPQ8wW1KbwYsH-8Rgr9UJ5eytOn8tKBN38_7hH_01YC3i2An4__k90DMlCnyA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2406304636</pqid></control><display><type>article</type><title>Medical Conditions Linked to Atherosclerosis Are Associated With Magnified Cortical Thinning in Individuals With Alcohol Use Disorders</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Durazzo, Timothy C ; Nguyen, Linh-Chi ; Meyerhoff, Dieter J</creator><creatorcontrib>Durazzo, Timothy C ; Nguyen, Linh-Chi ; Meyerhoff, Dieter J</creatorcontrib><description>Abstract
Aims
Magnetic resonance imaging (MRI) studies report widespread cortical thinning in individuals with alcohol use disorder (AUD), but did not consider potential effects of pro-atherogenic conditions such as hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia on cortical thickness. The conditions are associated with regional cortical thinning in those without AUD. We predicted that individuals with concurrent AUD and pro-atherogenic conditions demonstrate the greatest regional cortical thinning in areas most vulnerable to decreased perfusion.
Methods
Treatment-seeking individuals with AUD (n = 126) and healthy controls (CON; n = 49) completed a 1.5 T MRI study. Regional cortical thickness was quantitated via FreeSurfer. Individuals with AUD and pro-atherogenic conditions (Atherogenic+), AUD without pro-atherogenic conditions (Atherogenic−) and CON were compared on regional cortical thickness.
Results
Individuals with AUD showed significant bilateral cortical thinning compared to CON, but Atherogenic+ demonstrated the most widespread and greatest magnitude of regional thinning, while Atherogenic− had reduced thickness primarily in anterior frontal and posterior parietal lobes. Atherogenic+ also showed a thinner cortex than Atherogenic− in lateral orbitofrontal and dorso/dorsolateral frontal cortex, mesial and lateral temporal and inferior parietal regions.
Conclusions
Our results demonstrate significant bilateral cortical thinning in individuals with AUD relative to CON, but the distribution and magnitude were influenced by comorbid pro-atherogenic conditions. The magnitude of cortical thinning in Atherogenic+ strongly corresponded to cortical watershed areas susceptible to decreased perfusion, which may result in morphometric abnormalities. The findings indicate that pro-atherogenic conditions may contribute to cortical thinning in those seeking treatment for AUD.
Individuals with an alcohol use disorder (AUD) and comorbid pro-atherogenic conditions of hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia showed significantly greater cortical thinning in multiple regions compared to AUD without pro-atherogenic conditions and healthy controls. Findings indicated pro-atherogenic conditions may exacerbate brain structural deficits in AUD.</description><identifier>ISSN: 0735-0414</identifier><identifier>ISSN: 1464-3502</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agaa034</identifier><identifier>PMID: 32445335</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Alcoholism - complications ; Atherosclerosis - diagnostic imaging ; Case-Control Studies ; Cerebral Cortical Thinning - diagnostic imaging ; Cerebral Cortical Thinning - etiology ; Diabetes Mellitus, Type 2 - complications ; Female ; Hepatitis C - complications ; Humans ; Hyperlipidemias - complications ; Hypertension - complications ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Risk Factors</subject><ispartof>Alcohol and alcoholism (Oxford), 2020-06, Vol.55 (4), p.382-390</ispartof><rights>The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. All rights reserved. 2020</rights><rights>The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-1009052cb11389de781154e0098242aec5504b794934ba3fdfb898f4ebe197093</citedby><cites>FETCH-LOGICAL-c424t-1009052cb11389de781154e0098242aec5504b794934ba3fdfb898f4ebe197093</cites><orcidid>0000-0002-5969-9544</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32445335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durazzo, Timothy C</creatorcontrib><creatorcontrib>Nguyen, Linh-Chi</creatorcontrib><creatorcontrib>Meyerhoff, Dieter J</creatorcontrib><title>Medical Conditions Linked to Atherosclerosis Are Associated With Magnified Cortical Thinning in Individuals With Alcohol Use Disorders</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol Alcohol</addtitle><description>Abstract
Aims
Magnetic resonance imaging (MRI) studies report widespread cortical thinning in individuals with alcohol use disorder (AUD), but did not consider potential effects of pro-atherogenic conditions such as hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia on cortical thickness. The conditions are associated with regional cortical thinning in those without AUD. We predicted that individuals with concurrent AUD and pro-atherogenic conditions demonstrate the greatest regional cortical thinning in areas most vulnerable to decreased perfusion.
Methods
Treatment-seeking individuals with AUD (n = 126) and healthy controls (CON; n = 49) completed a 1.5 T MRI study. Regional cortical thickness was quantitated via FreeSurfer. Individuals with AUD and pro-atherogenic conditions (Atherogenic+), AUD without pro-atherogenic conditions (Atherogenic−) and CON were compared on regional cortical thickness.
Results
Individuals with AUD showed significant bilateral cortical thinning compared to CON, but Atherogenic+ demonstrated the most widespread and greatest magnitude of regional thinning, while Atherogenic− had reduced thickness primarily in anterior frontal and posterior parietal lobes. Atherogenic+ also showed a thinner cortex than Atherogenic− in lateral orbitofrontal and dorso/dorsolateral frontal cortex, mesial and lateral temporal and inferior parietal regions.
Conclusions
Our results demonstrate significant bilateral cortical thinning in individuals with AUD relative to CON, but the distribution and magnitude were influenced by comorbid pro-atherogenic conditions. The magnitude of cortical thinning in Atherogenic+ strongly corresponded to cortical watershed areas susceptible to decreased perfusion, which may result in morphometric abnormalities. The findings indicate that pro-atherogenic conditions may contribute to cortical thinning in those seeking treatment for AUD.
Individuals with an alcohol use disorder (AUD) and comorbid pro-atherogenic conditions of hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia showed significantly greater cortical thinning in multiple regions compared to AUD without pro-atherogenic conditions and healthy controls. Findings indicated pro-atherogenic conditions may exacerbate brain structural deficits in AUD.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcoholism - complications</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Case-Control Studies</subject><subject>Cerebral Cortical Thinning - diagnostic imaging</subject><subject>Cerebral Cortical Thinning - etiology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Female</subject><subject>Hepatitis C - complications</subject><subject>Humans</subject><subject>Hyperlipidemias - complications</subject><subject>Hypertension - complications</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><issn>0735-0414</issn><issn>1464-3502</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EosPAliXyEhZp7fhlkmyQoqFApanYtGJpOc7L5EHGHuykEj_Ad9clQwUrpMiR7eNj617GXktxLkWtLsxo03dh9sYIBU_YSsIGMlWI_ClbiVIVmQAJZ-xFjN-EkKBy-ZydqRygUKpYsV_X2FFS8K13HU3kXeQ7ct-x45PnzTRg8NGODyNF3gTkTYzekpkS8ZWmgV-bvaOe0nTrw_TbdTOQc-T2nBy_Sto76mYzxoVvRusHP_LbiPwDRR86DPEle9YnAl-d_mt2-_HyZvs52335dLVtdpmFHKZMClGLIretlKqqOywrKQvAtFrlkBu0RSGgLWuoFbRG9V3fVnXVA7Yo6zLltWbvF-9xbg_YWXRTMKM-BjqY8FN7Q_rfHUeD3vs7XaoUZopvzd6eBMH_mDFO-kDR4jgah36OOgexUQI2apPQ8wW1KbwYsH-8Rgr9UJ5eytOn8tKBN38_7hH_01YC3i2An4__k90DMlCnyA</recordid><startdate>20200625</startdate><enddate>20200625</enddate><creator>Durazzo, Timothy C</creator><creator>Nguyen, Linh-Chi</creator><creator>Meyerhoff, Dieter J</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5969-9544</orcidid></search><sort><creationdate>20200625</creationdate><title>Medical Conditions Linked to Atherosclerosis Are Associated With Magnified Cortical Thinning in Individuals With Alcohol Use Disorders</title><author>Durazzo, Timothy C ; Nguyen, Linh-Chi ; Meyerhoff, Dieter J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-1009052cb11389de781154e0098242aec5504b794934ba3fdfb898f4ebe197093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcoholism - complications</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Case-Control Studies</topic><topic>Cerebral Cortical Thinning - diagnostic imaging</topic><topic>Cerebral Cortical Thinning - etiology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Female</topic><topic>Hepatitis C - complications</topic><topic>Humans</topic><topic>Hyperlipidemias - complications</topic><topic>Hypertension - complications</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durazzo, Timothy C</creatorcontrib><creatorcontrib>Nguyen, Linh-Chi</creatorcontrib><creatorcontrib>Meyerhoff, Dieter J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durazzo, Timothy C</au><au>Nguyen, Linh-Chi</au><au>Meyerhoff, Dieter J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medical Conditions Linked to Atherosclerosis Are Associated With Magnified Cortical Thinning in Individuals With Alcohol Use Disorders</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol Alcohol</addtitle><date>2020-06-25</date><risdate>2020</risdate><volume>55</volume><issue>4</issue><spage>382</spage><epage>390</epage><pages>382-390</pages><issn>0735-0414</issn><issn>1464-3502</issn><eissn>1464-3502</eissn><abstract>Abstract
Aims
Magnetic resonance imaging (MRI) studies report widespread cortical thinning in individuals with alcohol use disorder (AUD), but did not consider potential effects of pro-atherogenic conditions such as hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia on cortical thickness. The conditions are associated with regional cortical thinning in those without AUD. We predicted that individuals with concurrent AUD and pro-atherogenic conditions demonstrate the greatest regional cortical thinning in areas most vulnerable to decreased perfusion.
Methods
Treatment-seeking individuals with AUD (n = 126) and healthy controls (CON; n = 49) completed a 1.5 T MRI study. Regional cortical thickness was quantitated via FreeSurfer. Individuals with AUD and pro-atherogenic conditions (Atherogenic+), AUD without pro-atherogenic conditions (Atherogenic−) and CON were compared on regional cortical thickness.
Results
Individuals with AUD showed significant bilateral cortical thinning compared to CON, but Atherogenic+ demonstrated the most widespread and greatest magnitude of regional thinning, while Atherogenic− had reduced thickness primarily in anterior frontal and posterior parietal lobes. Atherogenic+ also showed a thinner cortex than Atherogenic− in lateral orbitofrontal and dorso/dorsolateral frontal cortex, mesial and lateral temporal and inferior parietal regions.
Conclusions
Our results demonstrate significant bilateral cortical thinning in individuals with AUD relative to CON, but the distribution and magnitude were influenced by comorbid pro-atherogenic conditions. The magnitude of cortical thinning in Atherogenic+ strongly corresponded to cortical watershed areas susceptible to decreased perfusion, which may result in morphometric abnormalities. The findings indicate that pro-atherogenic conditions may contribute to cortical thinning in those seeking treatment for AUD.
Individuals with an alcohol use disorder (AUD) and comorbid pro-atherogenic conditions of hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia showed significantly greater cortical thinning in multiple regions compared to AUD without pro-atherogenic conditions and healthy controls. Findings indicated pro-atherogenic conditions may exacerbate brain structural deficits in AUD.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32445335</pmid><doi>10.1093/alcalc/agaa034</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5969-9544</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Alcoholism - complications Atherosclerosis - diagnostic imaging Case-Control Studies Cerebral Cortical Thinning - diagnostic imaging Cerebral Cortical Thinning - etiology Diabetes Mellitus, Type 2 - complications Female Hepatitis C - complications Humans Hyperlipidemias - complications Hypertension - complications Magnetic Resonance Imaging - methods Male Middle Aged Risk Factors |
| title | Medical Conditions Linked to Atherosclerosis Are Associated With Magnified Cortical Thinning in Individuals With Alcohol Use Disorders |
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