Histone acetyltransferase 1 is required for DNA replication fork function and stability

The replisome is a protein complex on the DNA replication fork and functions in a dynamic environment at the intersection of parental and nascent chromatin. Parental nucleosomes are disrupted in front of the replication fork. The daughter DNA duplexes are packaged with an equal amount of parental an...

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Veröffentlicht in:	The Journal of biological chemistry 2020-06, Vol.295 (25), p.8363-8373
Hauptverfasser:	Agudelo Garcia, Paula A., Lovejoy, Callie M., Nagarajan, Prabakaran, Park, Dongju, Popova, Liudmila V., Freitas, Michael A., Parthun, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylation acetyltransferase Animals Cell Line chromatin Chromatin - metabolism chromatin assembly Chromatin Assembly and Disassembly DNA - metabolism DNA and Chromosomes DNA Replication Gene Knockout Techniques HAT1 histone acetylase Histone Acetyltransferases - deficiency Histone Acetyltransferases - genetics Histone Acetyltransferases - metabolism Mice MRE11 Homologue Protein - metabolism replication fork replication fork stalling replication stress
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