Inferring Transmission Bottleneck Size from Viral Sequence Data Using a Novel Haplotype Reconstruction Method

The transmission bottleneck is defined as the number of viral particles that transmit from one host to establish an infection in another. Genome sequence data have been used to evaluate the size of the transmission bottleneck between humans infected with the influenza virus; however, the methods use...

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Veröffentlicht in:	Journal of virology 2020-06, Vol.94 (13)
Hauptverfasser:	Ghafari, Mahan, Lumby, Casper K, Weissman, Daniel B, Illingworth, Christopher J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Evolution, Molecular Genetic Diversity and Evolution Genetic Variation - genetics Genome, Viral - genetics Haplotypes - genetics Humans Influenza A virus - genetics Influenza A virus - metabolism Influenza, Human - genetics Influenza, Human - transmission Models, Theoretical Sequence Analysis, DNA - methods Viruses - genetics
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