Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components

One of the key mechanisms used by cells to control the spatiotemporal organization of their many components is the formation and dissolution of biomolecular condensates through liquid–liquid phase separation (LLPS). Using a minimal coarse-grained model that allows us to simulate thousands of interac...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-06, Vol.117 (24), p.13238-13247
Hauptverfasser:	Espinosa, Jorge R., Joseph, Jerelle A., Sanchez-Burgos, Ignacio, Garaizar, Adiran, Frenkel, Daan, Collepardo-Guevara, Rosana
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biomolecules Clients Composition Computer simulation Condensates Connectivity Critical point Introduced species Liquid phases Parameters Phase separation Physical properties Physical Sciences Protein interaction Proteins Scaffolds Stability Topology Valency
Online-Zugang:	Volltext
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