Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China
Goats are one of the most widespread farmed animals across the world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic...
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| Veröffentlicht in: | Molecular biology and evolution 2020-07, Vol.37 (7), p.2099-2109 |
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| creator | Cai, Yudong Fu, Weiwei Cai, Dawei Heller, Rasmus Zheng, Zhuqing Wen, Jia Li, Hui Wang, Xiaolong Alshawi, Akil Sun, Zhouyong Zhu, Siqi Wang, Juan Yang, Miaomiao Hu, Songmei Li, Yan Yang, Zhirui Gong, Mian Hou, Yunan Lan, Tianming Wu, Kui Chen, Yulin Jiang, Yu Wang, Xihong |
| description | Goats are one of the most widespread farmed animals across the world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic affinities between ancient and modern Chinese goats, demonstrating their genetic continuity. We found that Chinese goats originated from the eastern regions around the Fertile Crescent, and we estimated that the ancestors of Chinese goats diverged from this population in the Chalcolithic period. Modern Chinese goats were divided into a northern and a southern group, coinciding with the most prominent climatic division in China, and two genes related to hair follicle development, FGF5 and EDA2R, were highly divergent between these populations. We identified a likely causal de novo deletion near FGF5 in northern Chinese goats that increased to high frequency over time, whereas EDA2R harbored standing variation dating to the Neolithic. Our findings add to our understanding of the genetic composition and local evolutionary process of Chinese goats. |
| doi_str_mv | 10.1093/molbev/msaa103 |
| format | Article |
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Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic affinities between ancient and modern Chinese goats, demonstrating their genetic continuity. We found that Chinese goats originated from the eastern regions around the Fertile Crescent, and we estimated that the ancestors of Chinese goats diverged from this population in the Chalcolithic period. Modern Chinese goats were divided into a northern and a southern group, coinciding with the most prominent climatic division in China, and two genes related to hair follicle development, FGF5 and EDA2R, were highly divergent between these populations. We identified a likely causal de novo deletion near FGF5 in northern Chinese goats that increased to high frequency over time, whereas EDA2R harbored standing variation dating to the Neolithic. Our findings add to our understanding of the genetic composition and local evolutionary process of Chinese goats.</description><identifier>ISSN: 0737-4038</identifier><identifier>EISSN: 1537-1719</identifier><identifier>DOI: 10.1093/molbev/msaa103</identifier><identifier>PMID: 32324877</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adaptation, Biological ; Animals ; Biological Evolution ; China ; Discoveries ; DNA, Ancient - chemistry ; Genome ; Goats - genetics ; Selection, Genetic</subject><ispartof>Molecular biology and evolution, 2020-07, Vol.37 (7), p.2099-2109</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-5ea7adfc8044787f30580d0d7fab5026c465bc4d0ed1c67bd7c7627a30f010fe3</citedby><cites>FETCH-LOGICAL-c490t-5ea7adfc8044787f30580d0d7fab5026c465bc4d0ed1c67bd7c7627a30f010fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306693/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306693/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1598,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32324877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Yudong</creatorcontrib><creatorcontrib>Fu, Weiwei</creatorcontrib><creatorcontrib>Cai, Dawei</creatorcontrib><creatorcontrib>Heller, Rasmus</creatorcontrib><creatorcontrib>Zheng, Zhuqing</creatorcontrib><creatorcontrib>Wen, Jia</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Wang, Xiaolong</creatorcontrib><creatorcontrib>Alshawi, Akil</creatorcontrib><creatorcontrib>Sun, Zhouyong</creatorcontrib><creatorcontrib>Zhu, Siqi</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Yang, Miaomiao</creatorcontrib><creatorcontrib>Hu, Songmei</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Yang, Zhirui</creatorcontrib><creatorcontrib>Gong, Mian</creatorcontrib><creatorcontrib>Hou, Yunan</creatorcontrib><creatorcontrib>Lan, Tianming</creatorcontrib><creatorcontrib>Wu, Kui</creatorcontrib><creatorcontrib>Chen, Yulin</creatorcontrib><creatorcontrib>Jiang, Yu</creatorcontrib><creatorcontrib>Wang, Xihong</creatorcontrib><title>Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China</title><title>Molecular biology and evolution</title><addtitle>Mol Biol Evol</addtitle><description>Goats are one of the most widespread farmed animals across the world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic affinities between ancient and modern Chinese goats, demonstrating their genetic continuity. We found that Chinese goats originated from the eastern regions around the Fertile Crescent, and we estimated that the ancestors of Chinese goats diverged from this population in the Chalcolithic period. Modern Chinese goats were divided into a northern and a southern group, coinciding with the most prominent climatic division in China, and two genes related to hair follicle development, FGF5 and EDA2R, were highly divergent between these populations. We identified a likely causal de novo deletion near FGF5 in northern Chinese goats that increased to high frequency over time, whereas EDA2R harbored standing variation dating to the Neolithic. Our findings add to our understanding of the genetic composition and local evolutionary process of Chinese goats.</description><subject>Adaptation, Biological</subject><subject>Animals</subject><subject>Biological Evolution</subject><subject>China</subject><subject>Discoveries</subject><subject>DNA, Ancient - chemistry</subject><subject>Genome</subject><subject>Goats - genetics</subject><subject>Selection, Genetic</subject><issn>0737-4038</issn><issn>1537-1719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkUFr3DAQhUVpabbbXnMsOjYHJyNLtuxLICzpphBIKclZyNJ4V8GWNpK9kH8fhd2E9tTTDMw3b97wCDllcM6g5RdjGDrcX4xJawb8A1mwisuCSdZ-JAuQuRfAmxPyJaVHACZEXX8mJ7zkpWikXBB15Y1DP9E1-jBion9wj3qg0xbp9T4M8-SC1_GZ3rg0hVy1t_Quuo3zNPR0pdN2xIjF7xjsbJzf0HXQU6J5vNo6r7-ST70eEn471iV5-Hl9v7opbu_Wv1ZXt4URLUxFhVpq25sGhJCN7DlUDViwstddBWVtRF11RlhAy0wtOyuNrEupOfTAoEe-JJcH3d3cjWhNfinqQe2iG7N7FbRT_06826pN2CvJoa5bngV-HAVieJoxTWp0yeAwaI9hTqrkrWiaVmZ2Sc4PqIkhpYj9-xkG6jUVdUhFHVPJC9__NveOv8WQgbMDEObd_8ReAC-Sm0c</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Cai, Yudong</creator><creator>Fu, Weiwei</creator><creator>Cai, Dawei</creator><creator>Heller, Rasmus</creator><creator>Zheng, Zhuqing</creator><creator>Wen, Jia</creator><creator>Li, Hui</creator><creator>Wang, Xiaolong</creator><creator>Alshawi, Akil</creator><creator>Sun, Zhouyong</creator><creator>Zhu, Siqi</creator><creator>Wang, Juan</creator><creator>Yang, Miaomiao</creator><creator>Hu, Songmei</creator><creator>Li, Yan</creator><creator>Yang, Zhirui</creator><creator>Gong, Mian</creator><creator>Hou, Yunan</creator><creator>Lan, Tianming</creator><creator>Wu, Kui</creator><creator>Chen, Yulin</creator><creator>Jiang, Yu</creator><creator>Wang, Xihong</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200701</creationdate><title>Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China</title><author>Cai, Yudong ; Fu, Weiwei ; Cai, Dawei ; Heller, Rasmus ; Zheng, Zhuqing ; Wen, Jia ; Li, Hui ; Wang, Xiaolong ; Alshawi, Akil ; Sun, Zhouyong ; Zhu, Siqi ; Wang, Juan ; Yang, Miaomiao ; Hu, Songmei ; Li, Yan ; Yang, Zhirui ; Gong, Mian ; Hou, Yunan ; Lan, Tianming ; Wu, Kui ; Chen, Yulin ; Jiang, Yu ; Wang, Xihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-5ea7adfc8044787f30580d0d7fab5026c465bc4d0ed1c67bd7c7627a30f010fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adaptation, Biological</topic><topic>Animals</topic><topic>Biological Evolution</topic><topic>China</topic><topic>Discoveries</topic><topic>DNA, Ancient - chemistry</topic><topic>Genome</topic><topic>Goats - genetics</topic><topic>Selection, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Yudong</creatorcontrib><creatorcontrib>Fu, Weiwei</creatorcontrib><creatorcontrib>Cai, Dawei</creatorcontrib><creatorcontrib>Heller, Rasmus</creatorcontrib><creatorcontrib>Zheng, Zhuqing</creatorcontrib><creatorcontrib>Wen, Jia</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Wang, Xiaolong</creatorcontrib><creatorcontrib>Alshawi, Akil</creatorcontrib><creatorcontrib>Sun, Zhouyong</creatorcontrib><creatorcontrib>Zhu, Siqi</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Yang, Miaomiao</creatorcontrib><creatorcontrib>Hu, Songmei</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Yang, Zhirui</creatorcontrib><creatorcontrib>Gong, Mian</creatorcontrib><creatorcontrib>Hou, Yunan</creatorcontrib><creatorcontrib>Lan, Tianming</creatorcontrib><creatorcontrib>Wu, Kui</creatorcontrib><creatorcontrib>Chen, Yulin</creatorcontrib><creatorcontrib>Jiang, Yu</creatorcontrib><creatorcontrib>Wang, Xihong</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular biology and evolution</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Yudong</au><au>Fu, Weiwei</au><au>Cai, Dawei</au><au>Heller, Rasmus</au><au>Zheng, Zhuqing</au><au>Wen, Jia</au><au>Li, Hui</au><au>Wang, Xiaolong</au><au>Alshawi, Akil</au><au>Sun, Zhouyong</au><au>Zhu, Siqi</au><au>Wang, Juan</au><au>Yang, Miaomiao</au><au>Hu, Songmei</au><au>Li, Yan</au><au>Yang, Zhirui</au><au>Gong, Mian</au><au>Hou, Yunan</au><au>Lan, Tianming</au><au>Wu, Kui</au><au>Chen, Yulin</au><au>Jiang, Yu</au><au>Wang, Xihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China</atitle><jtitle>Molecular biology and evolution</jtitle><addtitle>Mol Biol Evol</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>37</volume><issue>7</issue><spage>2099</spage><epage>2109</epage><pages>2099-2109</pages><issn>0737-4038</issn><eissn>1537-1719</eissn><abstract>Goats are one of the most widespread farmed animals across the world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic affinities between ancient and modern Chinese goats, demonstrating their genetic continuity. We found that Chinese goats originated from the eastern regions around the Fertile Crescent, and we estimated that the ancestors of Chinese goats diverged from this population in the Chalcolithic period. Modern Chinese goats were divided into a northern and a southern group, coinciding with the most prominent climatic division in China, and two genes related to hair follicle development, FGF5 and EDA2R, were highly divergent between these populations. We identified a likely causal de novo deletion near FGF5 in northern Chinese goats that increased to high frequency over time, whereas EDA2R harbored standing variation dating to the Neolithic. Our findings add to our understanding of the genetic composition and local evolutionary process of Chinese goats.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>32324877</pmid><doi>10.1093/molbev/msaa103</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Open Access Collection; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adaptation, Biological Animals Biological Evolution China Discoveries DNA, Ancient - chemistry Genome Goats - genetics Selection, Genetic |
| title | Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China |
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