HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

DNA replication stress can stall replication forks, leading to genome instability. DNA damage tolerance pathways assist fork progression, promoting replication fork reversal, translesion DNA synthesis (TLS), and repriming. In the absence of the fork remodeler HLTF, forks fail to slow following repli...

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Veröffentlicht in:	Molecular cell 2020-06, Vol.78 (6), p.1237-1251.e7
Hauptverfasser:	Bai, Gongshi, Kermi, Chames, Stoy, Henriette, Schiltz, Carl J., Bacal, Julien, Zaino, Angela M., Hadden, M. Kyle, Eichman, Brandt F., Lopes, Massimo, Cimprich, Karlene A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor DNA - biosynthesis DNA - genetics DNA Damage - genetics DNA Primase - metabolism DNA Primase - physiology DNA Repair - genetics DNA Replication - genetics DNA Replication - physiology DNA replication, replication stress response, fork reversal, HLTF, PRIMPOL, REV1, DNA damage tolerance, translesion synthesis, ATR inhibition, replication catastrophe DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Directed DNA Polymerase - metabolism DNA-Directed DNA Polymerase - physiology HEK293 Cells Humans K562 Cells Multifunctional Enzymes - metabolism Multifunctional Enzymes - physiology Nucleotidyltransferases - metabolism Nucleotidyltransferases - physiology Transcription Factors - genetics Transcription Factors - metabolism
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