Impact of the Protein Data Bank on antineoplastic approvals

•Protein Data Bank (PDB) provides open access to >160K 3D structures of biomolecules.•79 anticancer NMEs with known molecular targets were approved by the FDA 2010–2018.•PDB provides target structures for >90% of anticancer NMEs approved 2010–2018.•PDB provides target–NME co-structures for >...

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Veröffentlicht in:	Drug discovery today 2020-05, Vol.25 (5), p.837-850
Hauptverfasser:	Westbrook, John D., Soskind, Rose, Hudson, Brian P., Burley, Stephen K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Databases, Protein Drug Discovery - methods Humans Melanoma - drug therapy Protein Conformation Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology
Online-Zugang:	Volltext
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