Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

Brief refeeding times (~60 min) enhanced hepatic Angptl8 expression in fasted mice. We cloned the mouse Angptl8 promoter region to characterise this rapid refeeding-induced increase in hepatic Angptl8 expression. Deletion of the −309/−60 promoter region significantly attenuated basal promoter activi...

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Veröffentlicht in:	Scientific reports 2020-06, Vol.10 (1), p.9999-9999, Article 9999
Hauptverfasser:	Watanabe, Takuya, Ozawa, Atsushi, Masuda, Shinnosuke, Yoshino, Satoshi, Ishida, Emi, Kondo, Yuri, Matsumoto, Shunichi, Katano-Toki, Akiko, Horiguchi, Kazuhiko, Nakajima, Yasuyo, Yamada, Eijiro, Tomaru, Takuya, Saito, Tsugumichi, Ishii, Sumiyasu, Shibusawa, Nobuyuki, Okada, Shuichi, Satoh, Tetsurou, Yamada, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 14/1 42/89 631/208/200 631/337 64/60 Angiopoietin-like Proteins - genetics Angiopoietin-like Proteins - metabolism Animals Binding sites Cell Line Chromatin Chromatin Immunoprecipitation Computer applications Electrophoretic mobility Gene deletion Gene Expression Regulation Gene regulation Hepatocyte Nuclear Factor 1 - genetics Hepatocyte Nuclear Factor 1 - metabolism Hepatocytes Hepatocytes - metabolism Hepatoma Humanities and Social Sciences Immunoprecipitation Insulin Liver Liver - metabolism Mice multidisciplinary Promoter Regions, Genetic Proteins Science Science (multidisciplinary) Transcription Transcription, Genetic - genetics Transfection
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