Identification of a periodontal pathogen and bihormonal cells in pancreatic islets of humans and a mouse model of periodontitis

Results from epidemiological and prospective studies indicate a close association between periodontitis and diabetes. However the mechanisms by which periodontal pathogens influence the development of prediabetes/diabetes are not clear. We previously reported that oral administration of a periodonta...

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Veröffentlicht in:	Scientific reports 2020-06, Vol.10 (1), p.9976, Article 9976
Hauptverfasser:	Ilievski, Vladimir, Toth, Peter T., Valyi-Nagy, Klara, Valyi-Nagy, Tibor, Green, Stefan J., Marattil, Rosann S., Aljewari, Haider W., Wicksteed, Barton, O’Brien-Simpson, Neil M., Reynolds, Eric C., Layden, Brian T., Unterman, Terry G., Watanabe, Keiko
Format:	Artikel
Sprache:	eng
Schlagworte:	692/163 692/420 Animals Bacteroidaceae Infections - microbiology Beta cells Diabetes Diabetes mellitus Diabetes Mellitus - etiology Diabetes Mellitus - microbiology Disease Models, Animal Epidemiologic Studies Epidemiology Gingipain Glucose Intolerance - microbiology Glucose tolerance Gum disease Humanities and Social Sciences Humans Hyperinsulinemia Immunofluorescence Insulin Insulin Resistance - physiology Intolerance Islets of Langerhans - microbiology Localization Male Mice Mice, Inbred C57BL multidisciplinary Oral administration Pancreas Pathogens Periodontitis Periodontitis - complications Periodontitis - microbiology Porphyromonas gingivalis - isolation & purification Prediabetic State - etiology Prediabetic State - microbiology Prospective Studies Science Science (multidisciplinary)
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