Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages

Disturbed activation of autophagy is implicated in the pathogenesis of inflammatory bowel disease. Accordingly, several autophagy-related genes have been identified as Crohn’s disease susceptibility genes. We screened the autophagy activators from a library including 3,922 natural extracts using a h...

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Veröffentlicht in:	Scientific reports 2020-06, Vol.10 (1), p.9972-9972, Article 9972
Hauptverfasser:	Yasueda, Asuka, Kayama, Hisako, Murohashi, Michiko, Nishimura, Junichi, Wakame, Koji, Komatsu, Ken-ichi, Ogino, Takayuki, Miyoshi, Norikatsu, Takahashi, Hidekazu, Uemura, Mamoru, Matsuda, Chu, Kitagawa, Toru, Takeda, Kiyoshi, Ito, Toshinori, Doki, Yuichiro, Eguchi, Hidetoshi, Shimizu, Shigeomi, Mizushima, Tsunekazu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 692/4020 692/699 Animals Autophagy Autophagy - drug effects Catechin Cell activation Colitis Colitis - drug therapy Colitis - metabolism Colitis - prevention & control Crohn Disease - drug therapy Crohn Disease - metabolism Crohn Disease - prevention & control Crohn's disease Cytokines - metabolism Dextran Dextran Sulfate - pharmacology Ellagic acid Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Female Gallic acid Herbal medicine Herbal Medicine - methods Humanities and Social Sciences Inflammation - drug therapy Inflammation - metabolism Inflammation - prevention & control Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - prevention & control Intestine Intestines - drug effects Macrophages Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Microfilament Proteins - metabolism multidisciplinary Myeloid cells Myeloid Cells - drug effects Myeloid Cells - metabolism Phagocytosis Phytotherapy - methods Plant Preparations - pharmacology Plants, Medicinal - chemistry Rodents Sanguisorba - chemistry Sanguisorba officinalis Science Science (multidisciplinary) Sodium sulfate
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